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S Fazion

Publications and source records attributed to S Fazion.

4 recordsLinked to original sources
PubMed1990

Cardiovascular stability during the haemodialysis session: relationship between modelling and impedance parameters.

The percentage of body water, if calculated from impedance, was found to be significantly different from the classic 58%. This supports the view that the evaluation of the dialytic efficiency should be, in the near future, carried out on the basis of a 'two-pool' model instead of the old 'one-pool'. The serial collection of data during a dialytic session supported the hypothesis that, 90 min after the start or, in general, after a body-water loss of about 5%-6%, some fundamental changes in measured indexes (phase angle, systolic pressure, body volumes, correlation matrix) usually appear. Large-scale research, based on an RS 232 interface connected to a computerised program, will probably help in clarifying whether some major intra-dialytic phenomena could in the near future be easily and automatically predicted.

Body Water↗
PubMed1989

Different buffers for hemodiafiltration: a controlled study.

Hemodiafiltration (HDF) is usually performed using a dialytic solution (D) containing acetate (A) or bicarbonate (B) and a replacement fluid (RF) containing lactate (L). To clarify the role of buffers in HDF, 11 patients underwent different study periods, each three months long: bicarbonate hemodialysis (BHD = Baseline period); HDF with (A) in D and (L) in RF (first period of HDF); HDF with (A) in D and (B) in RF (second HDF); HDF with (B) in D and (L) in RF (third HDF); HDF with (B) in D and (B) in RF (fourth HDF = BHDF). HDF achieved: 1) an increase in dialytic efficiency (kt/V, 1.28), reducing the time-session (197 min); 2) an improvement in acid-base status (pre-dialytic values in BHDF: pH 7.36; pCO2 39.8 mmHg; HCO3- 21.8 mM/L); 3) better "dry weight" gain (reached in 92.8% of HDF and in 81% of BHD sessions); 4) a significant decrease, in dialytic side-effects (mainly during the third and fourth periods). On the whole, BHDF (HDF done using only bicarbonate buffer) represents an easy and safe technique, leading to better cardiovascular stability than BHD and HDF without bicarbonate buffer.

Acetates↗
PubMedDate not supplied

Carboplatin and etoposide in an out-patient schedule for the palliation of advanced non-small-cell lung cancer.

AIMS AND BACKGROUND: In Western countries, non-small-cell lung cancer is the most important cause of cancer-related death. To date, medical treatment for advanced stages remains of a palliative nature. METHODS: Forty-four patients with advanced non-small-cell lung cancer were treated in a phase II study with carboplatin and etoposide (each at 60 mg/m2 daily) in a 5-day schedule. Among 44 patients, 18 (40%) had stage IIIB disease and 26 (60%) had stage IV disease. RESULTS: Treatment was well tolerated, and the only significant side effect was alopecia. The overall response rate was 27% with 2 complete remissions; median survival time was 10.4 months. One of the 2 patients achieving a complete remission was still alive and disease free at 36 months from the start of therapy. An improvement of performance status was observed in 22 patients (50%). CONCLUSIONS: The combinations of carboplatin and etoposide using this schedule appears to be well tolerated and has some activity in the palliation of advanced non-small-cell lung cancer.

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