PubMed Health⌕ Search

Biomedical subjects

S Filipović

Publications and source records attributed to S Filipović.

16 recordsLinked to original sources
PubMed2005

[Biological activities of bone morphological protein in bone regeneration].

Bone matrix contents various development factors which control structuring and absorption and those factors play important role in bone and cartilage development. Bone morphological proteins are members of TGF-beta super family and their activity is certain becoming from the bone. This activity leads to the serial development processes which include chemo taxis, proliferation and differentiation which results in trans resistant formation of cartilage as well as production of life cells of a bone tissue. Biological activities of re combinative human bone morphogenetic protein 7 (rhBMP-7). induction bone formation of non critical size mandible defect of New Zealand rabbits were researched in the study. Markers of osteoblastic differential in the study included ALP specific activity. Histological analysis performed 7, 14, 30, 60 postoperative days, C-T analysis with determination Bone Mineral Density value of new structured tissue within the defect was done 30 days. Results indicate that ectopic bone formation has been inducted with rhBMP-7 and histological analysis shown mature bone with collagen and ostheociti 60th day. Early 7 day granulocyte tissue with angiogenesis was detected, and after 30 days ostheoblastsis shown with a lot of vascular and mezenhimal tissue. Ostheogenetic processes were characteristic for typical inter membraneous ossification without cartilage tissue. ALP activity was significantly increased 21 days. C-T and Bone Mineral Density value shown density of new structured tissue determinate as bone (413 mg/cm3 and 519 mg/cm3). Studies showed that concentration of 100 mg rhBMP-7 in collagen as career had strong ostheo inductive capacity. Conditions which module BMP depend ostheo induction should be considered in the future. Information could lead to improvements of rhBMP as substitution for bone graft in clinical practice.

Animals↗
PubMed1996

Prolactin and cortisol responses to fenfluramine in Parkinson's disease.

Dysfunction of the central serotonergic system has been associated with depression in Parkinson's disease. To evaluate central serotonergic function in Parkinson's disease in relation to depression, we examined prolactin and cortisol responses to a single-dose challenge with fenfluramine (60 mg orally), a serotonin releasing/uptake-inhibiting agent, in the course of 5 hours in 11 patients with Parkinson's disease associated with major depression (SADS-RDC), 22 nondepressed parkinsonians, and 20 age- and gender-matched healthy controls. No difference in cortisol responses were observed between the groups; however, prolactin responses to fenfluramine were significantly impaired in patients with Parkinson's disease compared to controls, and the response was significantly more blunted in parkinsonian patients with major depression in comparison with the nondepressed ones. These findings indicate that there is a diminished serotonergic responsivity in depression associated with Parkinson's disease.

Adult↗
PubMed1991

Serum and CSF immunological findings in ALS.

Serum and CSF immunological findings were analysed in 37 patients with amyotrophic lateral sclerosis (ALS). ALS patients had significantly higher mean values of serum IgG and complement component C4 and significantly lower mean value of total haemolytic titre of complement (THC) compared with normal controls. Incidence of immune complexes (ICs) was significantly higher in sera of ALS patients than in normal controls. There was no significant difference regarding mean serum levels of IgM, IgA, and complement components C3 and Factor B between patients and controls. The blood-brain barrier (BBB) damage was found in 46% of patients. Intrathecal IgG synthesis was detected in six patients (16%). These results support the hypothesis of immune system involvement in ALS.

Adult↗
PubMed1990

Auditory event-related potentials in different types of dementia.

Auditory event-related potentials were recorded in demented, drug-free patients with Huntington's disease and Alzheimer's disease, as well as in demented and nondemented patients with Parkinson's disease, who were matched for age, duration and stage of the disease. The normal P3 latency at a given age was predicted by using an age regression equation that had been calculated on the basis of the findings in 42 normal adults. Using this procedure, a prolonged P3 latency was found in about two thirds of demented patients, irrespectively of the underlying disease. Although the prolonged P3 latency proved to be useful electrophysiological correlate of dementing illness, no differences were found between the observed groups in respect to other components of the auditory event-related potentials (N1 and P2).

Adult↗
PubMed1990

The disturbance of nonverbal functions in dysphasia.

Various modalities of six neuropsychological functions (graphia, calculia, finger gnosis, right-left orientation, praxia and constructive praxia) referred to as parietal or nonverbal have been investigated in the light of speech disorders. We examined 20 patients with brain lesion of vascular origin, who met the diagnostic criteria of mild and moderate dysphagia, 13 patients with Wernicke's and 7 with Broca's dysphasia. Verbal and nonverbal functions in patients with ischemic focuses of the speech area of the left hemisphere were investigated the Boston Diagnostic Aphasia Examination (BDAE). The investigation revealed that the presence and the type of mild and moderate dysphasia had a noteworthy role in pathoplasticity of correlated signs, thus implying in clinical practice a parietal lesion. Generally, poorer and at the same time more heterogeneous results were obtained in patients with Wernicke's dysphasia, mostly on calculia and right-left orientation. Finger agnosia was not considered as an authentic parietal sign, while each modality of graphia was impaired to a varying extent in speech disorders caused by presylvian and retrosylvian lesions. The paper also deals with the significance of lobulus parietalis inferior in speech.

Aphasia↗
PubMed1990

Local treatment of spasmodic torticollis with botulinum toxin.

Fifteen patients with spasmodic torticollis were treated with local injections of botulinum--A toxin. All the patients were followed for a period of 4 to 7 months. Thirteen out of 15 patients (86%) improved in the amount of sustained movements of torticollis. In six out of 9 patients presenting with pain complete relief was noted. Beneficial effects of botulinum toxin injections lasted from 2 to 3 months, with reproducible efficacy after repeated injections. The most frequent side effect was dysphagia, presented in 10 patients.

Adult↗
PubMedDate not supplied

[Clinical features of essential tremor].

UNLABELLED: Essential tremor is a dominant hereditary disorder with incomplete penetration manifested in action, postural tremor with no signs of parkinsonism, cerebellar lesions or other neurological signs [1]. The diagnosis of essential tremor is established on the basis of the clinical picture, and is greatly variable and insufficiently defined [5]. MATERIAL AND METHODS: The study concerned patients with the diagnosis of essential tremor established by the International Association for Tremor Studies in 1995 where tremor was classified into definite++, possible and probable [6]. All patients were subjected to a special questionnaire including demographic and clinical characteristics of tremor. Detailed neurological examinations focusing the presence of extrapyramidal signs were carried out. Fischer's Exact test was used for statistical analysis. RESULTS: The study comprised 107 patients (55 males, 41 females), aged 17-84 years (57.3 +/- 15.6) and 7-77 (46.3 +/- 17.9) at onset of the disease. Postural tremor was present in 36% of patients, postural tremor with intentional deterioration in 16%, statopostural tremor in 21% and continuous tremor in 17% of subjects. Extrapyramidal signs were present in 31% of patients, and clumsiness in fine alternating movements was present in 17 patients. The patients with longer duration of illness were significantly more clumsy in fine alternating movements (Fischer's Exact test; p = 0.507 < 0.05), but not in the presence of extrapyramidal signs (Fischer's Exact test; p = 0.507 > 0.05). DISCUSSION: Essential tremor is described as a dominant inherited postural tremor. Koller et al. [9] describe dominantly kinetic tremor occurring with movements, while Martinelli et al. [10] describe continuous tremor manifested at rest, posture and with movements. Static tremor was considered as a result of the disease progression [8]. In our patients those with longer duration of the disease were frequently more clumsy in fine alternating movements, but not in manifestation of extrapyramidal signs. Continuous tremor is probably a subgroup of essential tremor; suggests a more pronounced role of cerebellum in its genesis.

Adolescent↗
PubMedDate not supplied

[The opioid peptide, beta-endorphin, in spontaneous vaginal delivery and cesarean section].

The opioid peptide, beta-endorphin, originates from proopiomelanocortin (POMC) under the influence of corticotropin releasing hormone (CHR). It increases the threshold of pain and has a certain influence on the formation of hypophyseal hormones, especially in stress. It is found that beta-endorphin stimulates the secretion of prolactin, a growth hormone, and vasopressin; it inhibates formation of follicle-stimulating and luteinizating hormones, oxytocin and dopamine, and gonadotropin, a releasing hormone. The process of acetylization decreases its activity. The results of experimental trials revealed that acetylisation in the foetal period was absent. The aim of the study was to define beta-endorphin concentration during normal vaginal labor and Cesarean section. Samples of peripheral blood of patients with spontaneous vaginal labor (n = 15) and of those in whom labor was operatively terminated (Cesarean section) (n = 10), were analysed. Values of this opiate were determined in the umbilical cord of newborn infants, in the amniotic fluid and placental compartment. The obtained results were statistically analysed. In intrapartum beta-endorphins were significantly increased reaching the highest level during expulsion (326 pg/ml); in the placental compartment these values were higher (in retroplacental blood 514 pg/ml) reaching the highest value of 917 pg/ml, p less than 0.01 in the placenta. In Cesarean section beta-endorphin values in the peripheral blood showed no significant differences during spontaneous vaginal labor. However, increased values of this natural opiate were observed six hours after surgery. Beta-endorphin concentrations in the placental compartment and the placenta during normal vaginal labor were significantly higher in comparison with labor by Cesarean section (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Cesarean Section↗
PubMedDate not supplied

[Delayed-onset dystonia due to asphyxia in the perinatal period].

The phenomenon of delayed-onset dystonia following presumed "static" brain injuries was described after stroke and head trauma. Burke et al. described a different category of secondary dystonia, where perinatal injury (asphyxia) caused minimal or no immediate neurological deficit, with the delay of years before dystonia emerged. This type of dystonia following perinatal injury has been termed "delayed onset dystonia due to static encephalopathy of childhood". According to the definition of dystonia, we were able to select 5 patients with the aetiologic diagnosis of perinatal asphyxia from the group of 347 out- and inpatients (1.4%) treated for various types of dystonia at the Movement Disorders Department (Institute of Neurology, CCS, Belgrade) from November 1986 to November 1994. At onset of dystonia the mean age of patients was 13.2 years (range from 10 to 17), with combined initial involvement of the arm and neck in 3 patients. The period from the onset of the disease to the maximum severity lasted 8.2 years (range from 4 to 14), resulting in segmental brachial dystonia in 3, hemidystonia and generalized dystonia in one patient each (Table 1). The adverse perinatal events are described in Table 2. Three of our patients had delayed achievements of developmental milestones. All patients were regularly schooled and had preserved intellectual capacities, except the patient 3 whose achievements were below average (IQ = 86). Different drugs were administered (Table 3), but moderate effects were achieved only with trihexyphenidyl in two patients (daily doses of 24 mg and 30 mg, respectively), and baclofen (80 mg p.d.) in one patient. In this study we describe 5 new patients who fulfilled the criteria for the diagnosis of delayed-onset dystonia due to perinatal asphyxia (Tables 1 and 2). We accepted the approach of Saint-Hilaire et al. to suggest a relationship between perinatal asphyxia and later occurrence of dystonia in our 5 patients. However, coincident occurrence of a primary dystonia with a static encephalopathy of childhood due to perinatal asphyxia cannot be excluded. This phenomenon of delayed appearance of dystonia was also described in other forms of static cerebral injury; i.e. stroke, head trauma or anoxic brain damage. Interestingly enough, age at the time of anoxia or brain insults seemed to be crucial for the development of dystonia: those who suffer acute brain insults during childhood or early life are more likely to develop dystonia than the older patients. Therefore, the "static" nature of encephalopathy induced by perinatal asphyxia is questionable. Finally, this study strengthens the suggestion that perinatal asphyxia can lead to delayed-onset dystonia, and, since "some of these patients closely resemble cases of idiopathic torsion dystonia, the prior occurrence of asphyxia should be used as a criterion of exclusion for that diagnosis".

Adolescent↗
PubMedDate not supplied

[The significance of physical activity and anthropometric parameters for the development of breast cancer].

The significance of physical activity and some anthropometric parameters (body mass, body height, body mass index) in breast cancer genesis was examined in the study. Anamnestic study included 106 women with breast cancer and 106 hospital controls, age-matched (+/-3 years). The data about risk factors for breast cancer genesis were collected by the targeted epidemiological questionnaire. The basic statistic parameters (mean, standard error) and t-test were calculated. The results indicated that physical activity and body height higher values appeared to be protective, while body mass and body mass index higher values could be considered as risk factors for breast cancer.

Body Constitution↗
PubMedDate not supplied

[Amiodarone--pro and con].

OBJECTIVE: To compare and evaluate the data for and against the use of antiarrhythmic agent amiodarone in known cardiological indications. DATA SOURCES: A MEDLINE search was used to identify the articles dealing with amiodarone, published in the last 15 years. STUDY SELECTION: Articles and studies (uncontrolled retrospective and controlled prospective), as well as case reports speaking decidedly for or against amiodarone were scrutinized. DATA EXTRACTION: Simple search, no particular conditions. CONCLUSIONS: Despite very numerous and serious side effects amiodarone is an extraordinary drug and can be recommended for use, provided that the physician is very well acquainted with all implications of its use. Large number of studies on a significant number of patients has proven the efficacy of amiodarone in supraventricular and ventricular arrhythmias of various origin. The drug is particularly suitable for the treatment of ventricular arrhythmia in patients with serious heart failure and impaired function of the left ventricle. It was successfully used in the treatment of malignant ventricular arrhythmias. In patients after myocardial infarction, intravenously administered amiodarone improved the chances of survival as well as the condition of arrhythmia, preventing spreading of the infarction. It is very convenient against ventricular arrhythmia after the successful resuscitation. Short-lasting intravenous administration of amiodarone does not cause serious side effects.

Amiodarone↗