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Biomedical subjects

S Finch

Publications and source records attributed to S Finch.

At least 19 recordsLinked to original sources
PubMed2004

Nutritional characteristics of people with impaired mental capacity from a nationally representative survey of British people aged 65 years and over.

BACKGROUND: Mentally impaired older people are frequently excluded from population surveys for practical reasons; thus their nutritional characteristics are poorly delineated. OBJECTIVE: To describe the nutritional characteristics of those who, through mental impairment, were considered to require proxy consent and/or proxy information-givers, within a National Diet and Nutrition Survey (NDNS) of people aged 65 years and over, in the UK. DESIGN AND METHODS: 2043 participants in the NDNS in mainland Britain during 1994-95 were studied. Proxy consent and/or proxy information was provided by the next-of-kin or a carer for 3% of people living in the community and for 35% of people in institutions. A four-day weighed diet estimate and a single blood sample for nutritional status and clinical chemistry indices were obtained. RESULTS: Inclusion of people requiring proxy consent and/or information was acceptable to NHS local research ethics committees. These participants differed in certain food choices, nutrient intakes and biochemical status indices, from those not requiring a proxy. They ate more sugary and milky foods. They had lower blood concentrations of haemoglobin, retinol, cholesterol; and higher plasma levels of urea and creatinine. CONCLUSIONS: Older people who require proxy consent or information-givers can be studied in population surveys. They are nutritionally vulnerable and may need special assistance to ensure acceptable nutritional intake and status.

Aged↗
PubMed2003

A confidence interval analysis of three studies using the Alzheimer's disease knowledge test.

It has been suggested that community awareness of Alzheimer's disease (AD) has increased over recent years. This claim has been difficult to evaluate given the lack of systematic research in this area however, despite some recent attempts at monitoring changes in knowledge about AD. To address the question of change in awareness about AD, the present study compared results from three studies that have investigated the level of AD knowledge among undergraduate students, using confidence intervals. Consistent with previous findings, the results of this study suggest that more recent cohorts of undergraduate students are more knowledgeable about some aspects of AD, although to an extent that is much less marked than previously thought. Importantly, there are also a number of areas in which there appears to have been little or no change in community awareness about AD, and these are highlighted as issues that may need to be specifically addressed as part of future career education programs.

Adult↗
PubMed2002

The relationship between oral health status and Body Mass Index among older people: a national survey of older people in Great Britain.

AIMS: To assess the relationship between oral health status and Body Mass Index. MATERIAL AND METHODS: This paper relates to the free-living sample (participants who lived in their own home, rather than an institution) of the National Diet and Nutrition Survey: people aged 65 years and older. SUBJECTS: 629 adults. DATA COLLECTION: A probability random national sample of adults who had a dental examination, an interview and an anthropometric examination. DATA ANALYSIS: Fisher's exact test and multivariate logistic modeling. FINDINGS: Being underweight was relatively uncommon in this population. People without teeth were significantly (P=0.05) more likely to be underweight than those with 11 or more teeth; 12.3% and 2.9%. A highly statistically significant (P=0.001) difference was observed in BMI between dentate people with 1-10 teeth and with more than 10 teeth; 24% and 2.9% were underweight. Dentate people with less than 21 natural teeth were on average more than 3 times more likely to be obese than those with 21-32 teeth (P=0.036). There was no significant difference in both the proportion of overweight and obese adults between those who were edentulous and dentate with 21 or more teeth. A similar pattern was observed when the number of posterior occluding pairs was compared with BMI categories. Results of multiple logistic regression were adjusted for the confounding effects of age, social class, region of origin and partial denture wearing. CONCLUSIONS: Older people in Britain with more than 20 teeth are more likely to have a normal Body Mass Index.

Aged↗
PubMed2001

JunB negatively regulates AP-1 activity and cell proliferation of malignant mouse keratinocytes.

OBJECTIVE: Previously we have shown that a malignant mouse keratinocyte cell line, 10Gy5, has elevated AP-1 transactivation and reduced JunB protein levels compared to its parental benign cell line, 308, and that the tumorigenicity in the 10Gy5 cells could be blocked by a dominant negative c-Jun mutant protein. We wished to determine whether the change in JunB protein levels could account for the elevated AP-1 activity and whether re-expression of JunB in malignant 10Gy5 cells altered their proliferative capacity. DESIGN: In the current study, we reduced JunB expression in benign 308 cells with antisense oligonucleotides and increased JunB expression in malignant 10Gy5 cells by stable transfection of a JunB expression vector. RESULTS: Increased AP-1 activity was detected after treatment of the benign 308 cell line with JunB antisense oligonucleotides that reduced JunB protein levels. Stably JunB-transfected clones of malignant 10Gy5 cells showed decreased AP-1 activity, slowed in vitro cell proliferation and reduced tumor growth when xenografted to athymic nude mice. CONCLUSION: These findings suggest that expression of JunB protein has a negative effect on malignant tumor cell proliferation in part through its ability to inhibit AP-1 transactivation.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed2001

Prevalence of impacts of dental and oral disorders and their effects on eating among older people; a national survey in Great Britain.

OBJECTIVE: The objective was to assess the prevalence, in a British population aged 65 years and older, of oral health related impacts and the effects they had on the quality of daily life and in particular on eating. METHODS: 753 free living and 202 institutionalised subjects aged 65 years and over, participating in the oral health survey of the British National Diet and Nutrition Survey (NDNS), had a dental examination and interview. Data on the impact of dental and oral disorders on the activities of daily living based upon the modified Oral Impacts on Daily Performance (OIDP) indicator were collected. RESULTS: 17% of the free living edentate participants reported that their mouth affected their pattern of daily living on a regular basis. Oral impacts levels were lowest in dentate subjects with the greatest number of teeth. For the dentate, the most common oral impacts were on eating and speaking. Impacts relating to emotional stability, sleeping, relaxing, carrying out physical activity and social contact were very infrequent, but were severe when they did occur. Among those with an impact on eating, 25% said it was severe and 42% had the impact nearly every day or in a spell of 3 or more months. Oral impacts were more prevalent among the institution sample, particularly the dentate. The impacts were associated with the inability or difficulty to eat a range of 16 common foods. CONCLUSION: This survey has shown that the oral status of older people fairly frequently affects the quality of life of older people, and in particular, the ability to eat several common types of foods.

Aged↗
PubMed2001

The relationship among dental status, nutrient intake, and nutritional status in older people.

Dental health status may influence nutrition. The objective of this part of the National Diet and Nutrition Survey was to assess if there is a relationship between dental status in people 65 years and older and intake of certain nutrients and any link between dental status and blood-derived values of key nutrients. Random national samples of independently living subjects and those living in institutions had dental examinations, interviews, four-day food diaries, and blood and urine analyzed. In the sample living independently, intakes of most nutrients were lower in edentate than dentate subjects. Intake of non-starch polysaccharides, protein, calcium, non-heme iron, niacin, and vitamin C was significantly lower in edentate subjects. People with 21 or more teeth consumed more of most nutrients, particularly of non-starch polysaccharide. This relationship in intake was not apparent in the hematological analysis. Plasma ascorbate and plasma retinol were the only analytes significantly associated with dental status.

Aged↗
PubMed2001

Geographical variations in nutrition-related vascular risk factors in the UK: National Diet and Nutrition Survey of People Aged 65 Years and Over.

BACKGROUND: There is a strong north-south gradient of vascular disease in Britain, whose aetiology is not fully understood. OBJECTIVE: To test the hypothesis, in a cross-sectional survey of older people, that intakes and status indices for protective micronutrients, particularly those for which fruit and vegetables are rich sources, also vary on a north-south axis. DESIGN: The 1994-5 National Diet and Nutrition Survey of People Aged 65 Years and Over has provided a uniquely appropriate data-set for this purpose. The analysis, confined to free-living participants, compared nutrient intakes and status between people living in the north of Britain, from Scotland to Humberside, with those living south of the Wash, excluding the Midlands and Wales. RESULTS: Highly significant north-south differences, especially for vitamin C, but also to a significant extent for B-vitamins and carotenoids, indicated a more vitamin-rich diet, with more frequent use of vitamin supplements, in the south. Vitamin D status and fibre intakes were also higher in the south; sodium intake was greater in the north. Blood lipid indices did not, however, differ between north and south. North-south differences in the likelihood of receiving income support, of having manual socio-economic status and of smoking habit, appeared to be significant underlying socio-demographic factors. CONCLUSION: These findings are consistent with the hypothesis that for older British people, differences in nutrient intake and status indices between the north and south of Britain run parallel with, and may contribute to, the north-south axis of vascular disease risk.

Aged↗
PubMed2001

Pest insect control in organically-produced crops of field vegetables.

In the UK, the demand for organic vegetable and salad crops is increasing, mainly as a result of the requirements of the multiple retailers. However, approximately 85% of the organic fruit and vegetable produce sold in the UK is imported. A major constraint to growing field vegetable crops, and particularly organically-produced crops, is the reduction in crop yield and quality caused by pest insects. This paper will consider the control techniques currently available to organic growers and other techniques that may become available in the future. Growing plant varieties with complete or even partial resistance to pest insects can be an effective way of reducing crop damage. There are already varieties of carrot, with resistance to carrot fly, and lettuce, with resistance to certain pest aphid species, which are available commercially. Cultural techniques to exclude, deter or avoid pest insects are also being used by some organic growers. Although isolating new crops from sources of infestation can be a highly effective control strategy, many organic growers cannot use it, as the land converted for organic production is still limited. Various crop covers can be used to prevent pest insects from damaging field crops, but to be effective such covers have to be in place before the pests enter the crop. Several researchers have tried to develop techniques to prevent pest insects from finding their host-plants. No technique involving semiochemicals has been sufficiently successful to be used in field vegetable production in the UK. Other studies have shown that the numbers of pest insects found on crop plants are reduced considerably when the crop is allowed to become weedy, is intercropped with another plant species, or is undersown with a living mulch. Hence, work is now needed to select background plant species that will both reduce pest insect numbers and cause the least reduction in yield to the harvested crop plants. There is also a need to obtain a better understanding of "companion planting", a practice used frequently by organic growers. To date, microbial control is the only biological technique that has been used successfully in field vegetable crops in the UK. However, only the toxicant produced by one microbial agent, the bacterium Bacillus thuringiensis, has so far been registered for use. The use of bacteria, fungi and viruses to control pests of field vegetable crops certainly has possibilities. However, in many cases there are still problems to be overcome to select pathogens that are compatible with, or can still be effective in, the wide fluctuations in temperature, humidity and soil moisture that occur under field conditions. Attempts are now being made to use entomopathogenic nematodes and predatory arthropods to control one major pest insect, the cabbage root fly. Techniques developed to improve the timing of application of various crop protection procedures in systems of conventional vegetable production apply equally well to organic production, despite the choice of control options being more limited. In particular, models to forecast the timing of pest insect attacks could be used to great effect, to indicate the best times to plant, protect and harvest a specific crop to minimise pest insect damage.

Agriculture↗
PubMed2001

Cabbage root fly control using non-organophosphorus insecticides.

The need to find non-organophosphorus insecticides to control the cabbage root fly has never been so urgent. Of the six non-OP insecticides tested, fipronil was the most effective but spinosad, diflubenzuron and cyromazine also showed considerable promise. As expected, the transplant drenches (34 mg active ingredient (a.i./plant) were more effective than the module drenches (5 mg a.i./plant), which in turn were more effective than the film-coated seed treatments (0.001 mg a.i./plant), simply because of the different amounts of insecticide applied per plant. One remaining major problem is that, even if effective non-OP insecticides can be found, the manufacturers may still not support their insecticides being applied to minor crops such as field vegetables.

Animals↗
PubMed2000

Longitudinally foretelling drug use in the late twenties: adolescent personality and social-environmental antecedents.

This research focuses on the interrelation of the parent-child attachment, unconventionality, friends' drug use, and the young adult's use of drugs. Data were collected from participants at 4 points in time: early adolescence, late adolescence, early 20s, and late 20s. Data were collected from mothers at the 3 points in time that corresponded with the first 3 collections of data from their children. Both the youths and their mothers were individually interviewed. The findings indicated that the effect of parent-child mutual attachment was mediated through early adolescent personality attributes of greater responsibility, less rebelliousness, and intolerance of deviance. These non-drug-prone personality and behavioral attitudes, in turn, insulated the young adult from affiliating with drug-using peers, and these attitudes were related to less drug use in the early 20s and ultimately in the late 20s. The results suggest that interventions focused on enhancing parent-child mutual attachment should result in a reduction of the risk factors conducive to drug use during the late 20s. The fact that these findings cover a decade and a half, from early adolescence to the late 20s, underscores the significance of placing drug use in a perspective that includes familial and behavioral aspects.

Adolescent↗
PubMed2000

Visual acuity measurements in a national sample of British elderly people.

BACKGROUND: Despite the fact that visual function has an important role in the quality of life in later years, very few studies have measured visual acuity in population based nationwide samples of British elderly people. Such measurements were carried out in the context of the national diet and nutrition survey of people aged 65 years or over (NDNS). METHODS: NDNS participants, who were living in 80 different randomly selected postcode areas of mainland Britain, were visited at their home by a nurse who measured visual acuity at 3 metres, using the Glasgow acuity card (GAC) method. In addition, a brief questionnaire related to ocular health was administered. RESULTS: Visual acuity was measured in 1362 NDNS participants who were not classified as mentally impaired. Visual impairment (using the WHO low vision criteria) was measured in 195 (14.3%) subjects. Prevalence of visual impairment increased significantly with age (65-74 years 3.1%; 75-84 years 11.6%; 85+ years 35.5%, p<0.001 for trend). Impaired vision was more common in subjects living in a nursing home (odds ratio adjusted for age 2.59 (95% CI 2.23 to 2. 96)) and in women (odds ratio adjusted for age 1.55 (95% CI 1.21 to 1.89)). 132 (9.7%) subjects had previously undergone cataract surgery and another 157 (11.5%) had been told that they currently had cataract. Vision improved 0.2 log units or more (at least one Snellen line) with the aid of a pinhole occluder in 289 subjects (21. 2%). CONCLUSION: Results of this nationwide, community based study confirm that problems with poor distance visual acuity exist in a substantial part of the elderly community, particularly in women and people living in nursing homes.

Aged↗
PubMed1999

Micronutrients: highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over.

The aims of the National Diet and Nutrition Survey series are summarized, and the new National Diet and Nutrition Survey of people aged 65 years and over is explored, with particular emphasis on micronutrient intakes and status indices. Mean nutrient intakes were generally satisfactory for most micronutrients, but intakes of vitamin D, Mg, K and Cu were low. Intakes of vitamin D were far below the reference nutrient intake for people aged 65 years and over, and there was also biochemical evidence of vitamin D deficiency, for 8% of free-living and 37% of institution participants, attributed partly to limited exposure to sunlight. A substantial proportion of people living in institutions had inadequate biochemical status indices, notably for vitamin C, Fe and folate. Relationships between intake and status were close for vitamins. Mineral intakes did not correlate well with currently used status indices. Some intakes and indices, especially those of vitamin C, carotenoids, Na and K, were strongly correlated with socio-economic status and with north-south gradients in Britain. Future research challenges should address the functional and health significance of low intakes and sub-optimal biochemical indices for certain micronutrients, especially for people living in institutions; the shortcomings of mineral status indices especially as indicators of mineral intake; the social and geographical inequalities of micronutrient intakes and status, and why micronutrient status deteriorates with increasing age. The answers to these questions will help to define the characteristics of nutritional risk for older people in Britain, and to clarify future needs for education and intervention.

Aged↗
PubMed1999

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices.

OBJECTIVE: To describe the extent of use of medicines by older people living in Britain, and to explore relationships with vitamin status indices. DESIGN: The National Diet and Nutrition Survey of people aged 65 years and over collected data from a British sample during 1994-95. The present study has made novel use of it, to relate medicine use with biochemical indices of vitamin status. SETTING: Eighty postcode areas, selected randomly from mainland Britain. SUBJECTS: 1506 people, 65 years and over gave information about use of medication, and a 4-day weighed food record. Three-quarters gave blood for status indices. RESULTS: 78% of those living in the community and 93% of those in institutions were using medication. Certain vitamin status indices: plasma retinol, erythrocyte folate and riboflavin, paradoxically suggested better status in users than in non-users of antihypertensive, gastrointestinal, central nervous system, corticosteroid or diabetic drugs. There was evidence of a link with renal insufficiency, especially for plasma retinol, but neither this nor increased nutrient intake, acute phase effects or haemoconcentration could explain the paradoxical associations. CONCLUSIONS: Caution is needed in interpreting certain vitamin status indices, especially in older people who are extensively using medicines. New vitamin indices are needed, to avoid confounding interferences.

Aged↗
PubMed1999

Gender differences in food and nutrient intakes and status indices from the National Diet and Nutrition Survey of people aged 65 years and over.

OBJECTIVES: To determine the patterns and possible explanations for gender differences in food choices, nutrient intakes and status indices, especially for micronutrients, in a representative sample of older people living in Britain, who participated in the National Diet and Nutrition Survey of people aged 65 y and over during 1994-95. DESIGN: The Survey procedures included a health-and-lifestyle interview, a four-day weighed diet record, anthropometric measurements and a fasting blood sample for biochemical indices. SETTING: Eighty randomly-selected postcode sectors from mainland Britain. SUBJECTS: Of 1556 older people not living in institutions who were interviewed, 80% agreed to provide a complete four-day diet record and 63% agreed to give a blood sample for status index measurements. INTERVENTIONS: None. MAIN RESULT: The most highly significant gender differences in food choices were that women ate more butter, full-fat milk and certain beverages, cakes, apples, pears and bananas, whereas men ate more eggs, sugar, certain meat products and drank more alcoholic drinks, especially beer and lager. When adjusted for energy intakes, the younger women (65-79 y) had higher intakes than the younger men, of fat, retinol, vitamin C and calcium. The older women (80+ y) had higher intakes than older men, of fat and vitamin E, but lower intakes of protein, zinc and beta-carotene. The younger women had better status indices than the younger men: for alpha- and beta-carotenes, beta-cryptoxanthin and vitamin C. Women had higher plasma concentrations of cholesterol and HDL cholesterol, phosphate and copper, but lower indices of iron and vitamin D status, than men. These gender differences in status were not altered by inclusion of the corresponding nutrient intakes in the model. CONCLUSIONS: There are gender differences in food choices, in energy and nutrient intakes and in nutritional blood status indices in older British people, especially those aged 65-79 y. Some of the status differences are attenuated in the age group of 80 y and older, whereas others are enhanced. The relationships between the quantity and type of foods or nutrients consumed, and nutrient status, are complex. With respect to suspected risk and protective factors for vascular disease, women aged 65-79 y had significantly better status for plasma alpha- and beta-carotene, ascorbate, HDL-cholesterol and homocysteine; but, in contrast, they had lower blood haemoglobin concentrations and higher concentrations of total and non-HDL-cholesterol.

Age Factors↗
PubMed1999

The impact of oral health on stated ability to eat certain foods; findings from the National Diet and Nutrition Survey of Older People in Great Britain.

OBJECTIVES: To assess how the dental status of older people's mouths affected their stated ability to eat common foods. DESIGN: Cross sectional study. SUBJECTS: Survey was part of the oral health component of the nationwide British National Diet and Nutrition Survey: people aged 65 years and older. Two separate representative samples aged 65 and over: a free-living and an institutional sample. 881 free-living and 275 institution subjects had a dental exam and were interviewed about ability to eat key foods. RESULTS: Significant percentages of free-living people had difficulty or could not eat at least 4 of 16 foods, and about 1 in 5 dentate stated they had difficulty eating or could not eat raw carrots, apples, well-done steak or nuts. More of the edentate subjects stated that they had difficulty eating than the dentate. Perceived chewing ability increased with increasing numbers of natural teeth and pairs of opposing posterior teeth. Subjects reporting a sociodental impact were more likely to consider that they were unable to eat foods that required more chewing. Associations remained valid after correction for the effects of age, sex, social class and denture wearing status and region. Perceived dryness did not affect significantly the stated ease of eating most foods. There were more dietary restrictions reported by the institution sample. Some foods, such as nuts, apples and raw carrots could not be eaten easily by over half of edentate people in the institution sample. CONCLUSIONS: The stated selection of foods are substantially affected by numbers of teeth and occluding pairs of posterior teeth and presence of full dentures in significant percentages of older people.

Aged↗