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Biomedical subjects

S Fishman

Publications and source records attributed to S Fishman.

81 records · Page 5Linked to original sources
PubMed1975

Determination of estrogens in dosage forms by fluorescence using dansyl chloride.

A sensitive, reproducible, fluorometric procedure for the determination of estrogens in pharmaceutical preparations is presented. The estrogens are determined fluorometrically following their reaction with dansyl chloride. The optimum conditions for the reaction such as pH, reaction solvent composition variations, and speed of reaction are discussed. In addition, a linearity study of the relationship between concentration and fluorescence intensity for estrone, estradiol, and ethinyl estradiol is reported. Solvent extraction procedures based on acid-base behavior or column chromatography are used when necessary to isolate the estrogen prior to reaction with dansyl chloride and fluorometric measurement. The recovery of estrogens from spiked samples indicated that the proposed method is efficient and reproducible. Comparison of the dansyl procedure with the official NF method in the analysis of estrone aqueous suspension showed the proposed method to be accurate and more precise than the NF assay. Estrone aqueous suspension, estradiol in sesame oil, estradiol valerate in castor oil and in sesame oil (in the latter case, in the presence of testosterone), estradiol benzoate in sesame oil, and ethinyl estradiol tablets (0.5 mg/tablet) from commercial sources were satisfactorily analyzed, with average results within compendial limits and no coefficient of variation greater than 2%.

Castor Oil↗
PubMedDate not supplied

Icelandic-Swedish-New York above-knee prosthetic sockets: pediatric experience.

The Icelandic-Swedish-New York (ISNY) above-knee prosthetic socket affords juvenile amputees improved comfort, function, and appearance. The flexible polyethylene socket and rigid frame facilitate accommodation to longitudinal and circumferential limb growth. Review of 10 subjects revealed that all who had worn pelvic band suspension with prior prosthesis having rigid sockets could use total or partial suction to suspend prostheses having ISNY sockets.

Adolescent↗
PubMedDate not supplied

Myoelectric and body-powered prostheses.

One hundred twenty below-elbow child amputees compared cosmetically identical myoelectric (MYO) and body-powered (BP) hands after wearing each for 3 months; 78% chose the MYO and 22% chose the BP. However, at 2-year follow-up, only 44% wore the MYO, 33% used a BP hand or hook, and 23% became nonwearers (NW). Eighty percent of children aged > or = 8 years used active prosthetic prehension for both the MYO and BP prostheses. Comparatively, only 30% aged < 8 years and 0% aged < 5 years demonstrated any active prosthetic prehension. Active BP wearers were clearly most pleased with the features of their prostheses.

Activities of Daily Living↗