Biomedical subjects

S Fløistrup

Publications and source records attributed to S Fløistrup.

4 recordsLinked to original sources

PubMed1988

Cardiac function at rest and during exercise in early and late alcohol intoxication.

Seven healthy men, aged 21 to 30 years, were investigated by radionuclide cardiography at rest and during submaximal exercise at heavy (early) and during declining (late) alcohol intoxication. Control studies, in which alcohol was substituted by an isocaloric, isovolumic drink, were performed on a different day. The left ventricular ejection fraction at rest decreased from 59 to 56% during early intoxication (serum ethanol 35 +/- 6 mmol/l), whereas no change was observed in the ejection fraction during exercise. No significant change was recorded in stroke volume after alcohol consumption as opposed to a small increase after ingestion of the caloric drink. Plasma noradrenaline concentrations were elevated during exercise and early intoxication. During late intoxication (serum ethanol 21 +/- 5 mmol/l) the left ventricular ejection fraction at rest was increased by 7% compared with the baseline value. At rest the heart rate was increased from 68 +/- 7 to 84 +/- 15 beats/min, whereas cardiac output had reverted to the baseline value. Plasma noradrenaline at late intoxication was increased both at rest and during exercise compared with the baseline values. Apart from tachycardia and a reduction in left ventricular volumes during late intoxication no alcohol induced hemodynamic changes occurred during exercise.

Adult↗

PubMed1988

Central and peripheral haemodynamic changes after alcohol ingestion.

Central and peripheral haemodynamic changes 1 and 8 hours after alcohol ingestion were studied in seven healthy men, aged 21-30 years, by radionuclide cardiography and strain gauge plethysmography. Heart rate (HR) increased by 12% and cardiac output (CO) by 24% 1 hour after alcohol ingestion (mean serum ethanol 35 mmol/l). Left ventricular (LV) ejection fraction (EF) decreased by 5% because of endsystolic dilation and the forearm blood flow increased by 140%. Eight hours after alcohol ingestion (serum ethanol 21 mmol/l.) hangover symptoms were present in all subjects. HR and CO remained increased by 19% and 23%, respectively. A 4% increase was recorded in LVEF. The total peripheral resistance was reduced by 25%, while the forearm blood flow had returned to baseline values. No significant changes in plasma catecholamines were recorded. Apart from a slight increase in CO at 1 hour no haemodynamic changes were recorded after ingestion of an isovolumic, isocaloric drink. The present findings suggest that acute alcohol intoxication causes impairment of LV contractility, but that tachycardia results in an increase in cardiac output accompanied by an increased blood flow in the forearm. In the early hangover phase, when the serum ethanol is still elevated, cardiac output remains enhanced because of tachycardia, although the sympathetic nervous activity as measured by the plasma norepinephrine level is not influenced. A reduced total peripheral resistance may contribute to the increase in LV contractility in spite of sustained alcohol intoxication.

Adult↗

PubMed1987

Experimental popliteal vein thrombosis.

A device for experimental popliteal vein 'thrombosis' was developed and tested on a group of eight normal volunteers. Scintigraphy of the vessels and plethysmographic venous emptying recordings were performed as test procedures. The experimental set-up consisted of a syringe piston connected to a manometer and pump. A graded pressure was exerted on the dorsal aspect of the vein visualized with gamma-camera after in vitro labelling of the autologous red blood cells with 99Tcm. The position of the piston was controlled with a cobalt marker. The device proved successful and may be used when evaluating noninvasive diagnostic methods for detecting deep vein thrombosis and studying the haemodynamic consequences of acute venous thrombosis.

Adult↗

PubMed1987

Interobserver variation of angioscintigraphy for deep vein thrombosis.

Angioscintigrams of the deep veins in the legs were obtained in a consecutive series of 119 patients, suspected of deep vein thrombosis. Two nuclear medicine specialists independently read the angioscintigrams for presence of focal-filling defects, increased tissue activity, or collaterals and gave a final diagnosis of deep vein thrombosis. The overall agreement for the four findings were 0.83, 0.74, 0.75, and 0.84, respectively. After adjusting the overall agreement for expected chance agreement, kappa values of 0.56, 0.47, 0.21, and 0.64 were obtained. The interobserver variation of the angioscintigraphic diagnosis for deep vein thrombosis is comparable to that of the radiographic phlebography. As the angioscintigraphic technique is almost without any risk and inconvenience to the patient, it constitutes a relevant diagnostic alternative in the diagnosis of deep vein thrombosis.

Adult↗