Comparison between various tumor marker.
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Biomarkers, Tumor↗
Biomedical subjects
S Francioni
Publications and source records attributed to S Francioni.
Tumor markers and chemotherapy.
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Biomarkers, Tumor↗
[The diagnostic significance of the blood chemical and histological parameters in a group of chronic alcoholics with hepatopathy].
Different hematochemical parameters using a histological sample (hepatic needle biopsy) were compared in patients affected by alcoholic liver diseases. In conclusion, the importance of hepatic needle biopsy is confirmed in the definitive diagnosis of this pathology.
Adult↗
[Behavior of alkaline phosphatase isoenzymes in liver diseases].
Levels of alkaline phosphatase isoenzymes in patients with hepatic diseases, liver tumours and in normal control groups were analysed. Attention was focused on the ALP 1 isoenzyme and its validity in the diagnosis of hepatic metastases was confirmed.
Alkaline Phosphatase↗
Alpha-fetoprotein and acute viral hepatitis type B.
Variations in AFP values in 5 subjects with acute viral hepatitis type B have been studied and also compared with other hepatic enzymes, bilirubin, hepatic markers by means of a seriated drawing of blood. The Authors have stressed the importance of AFP monitoring in hepatics, in order to evaluate a postnecrotic regeneration of the hepatic parenchyma.
Adult↗
Correlation between RIA-EIA-ELISA methods for alpha-fetoprotein research.
To-day, the possibility of researching alpha-fetoprotein is given not only by the RIA method but also some immunoenzymatic methods. The Authors have compared three types of methods: RIA, EIA and ELISA, and have also studied the correlation coefficient in 30 samples. Method in solid phase (coated-tubes) and mouse monoclonal antibodies are used for the radioimmunologic method. The ELISA method utilizes two monoclonal antibodies: the former is coated to the walls of the test tubes (mouse monoclonal antibodies) and the latter is labelled with bovine alkaline phosphatase. The EIA methods is a solid phase enzyme immunoassay based on the sandwich principle. It consists of beads coated of goat antibodies and goat anti-AFP antibodies conjugated with horseradish peroxidase. The correlation coefficient is: RIA-ELISA = r 0.95; RIA-EIA = r 0.93; EIA-ELISA = r 0.96. The correlation coefficient from both the RIA method (taken as a reference) and the immunoenzymatic methods is good, so that the passage from RIA to enzymatic methods is possible without problems of under or above dosage of alpha-fetoprotein values.
Enzyme-Linked Immunosorbent Assay↗
Chemotherapy and tumoral markers in ovarian carcinoma.
Variations in tumoral markers (CA 125, CEA, AFP) in women with primary epithelial invasive ovarian cancer, after surgical operation for hysterectomy and chemotherapeutic treatment have been studied. The Authors stress the importance of alpha-fetoprotein monitoring in these women in order to evaluate a cytotoxic effect of the drugs used for the chemiotherapy on liver tissue.
Antineoplastic Agents↗