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Biomedical subjects

S Friberg

Publications and source records attributed to S Friberg.

18 recordsLinked to original sources
PubMed1992

Straight leg raising test versus radiologic size, shape, and position of lumbar disc hernias.

In 30 patients with a computed tomography-verified lumbar disc herniation, the relation between the straight leg raising test and the size, shape, and position of the hernia was evaluated before, 3, and 24 months after inception of nonoperative treatment. Hernia size was expressed as an index relating it to the size of the spinal canal. The limitation of the straight leg raising test was not related to size or position of the hernia. Before treatment, straight leg raising was equally restricted in patients with sharply pointed or blunt hernias, but after 3 months straight leg raising was less limited in patients with sharply pointed hernias, whereas after 24 months straight leg raising was regularly normalized. Size index was lower for sharply pointed hernias at all three computed tomography scans. A decrease in hernia size over time, irrespective of shape, was not correlated to a concomitant improvement in straight leg raising. It must be presumed that additional factors, such as inflammatory reactions affecting the nerve roots, are of importance for the magnitude of straight leg raising.

Adult↗
PubMed1992

C-reactive protein (CRP) levels after elective orthopedic surgery.

The levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were determined by serial measurements after four types of uncomplicated elective orthopedic surgery. The type of operations chosen for this study were total hip arthroplasty (primary, n = 109; and revisions caused by aseptic loosening, n = 9), unicondylar knee arthroplasty (n = 39), and lumbar microdiskectomy (n = 36). In all patients, CRP levels increased after surgery, reaching peak levels on the third day after hip arthroplasties (primary, 116 +/- 43 mg/l; revisions, 136 +/- 58 mg/l) and on the second day after knee arthroplasties (140 +/- 46 mg/l) and lumbar microdiskectomy (48 +/- 27 mg/l). C-reactive protein levels usually dropped to normal (less than 10 mg/l) within 21 days after surgery. No correlations were found between CRP response and the type of anesthesia, amount of bleeding, transfusion, operation time, administered drugs, age, or gender. Erythrocyte sedimentation rate increased to peak levels about five days after surgery, followed by a slow and irregular decrease. Still, 42 days after uncomplicated operations ESR often remained elevated. In conclusion, the level of CRP must be considered a better diagnostic aid for the early detection of postoperative infections than ESR. It can be assumed that the rapid decline in CRP after uncomplicated orthopedic surgery will be interrupted by a second rise or by a persisting elevated level if infectious complications occur.

Adult↗
PubMed1990

Trochanteric fractures. Mobility, complications, and mortality in 607 cases treated with the sliding-screw technique.

Six hundred seven trochanteric fractures (563 patients) were treated with a sliding-screw technique and followed clinically and roentgenographically for at least one year. Of 351 patients admitted from their homes, 209 (60%) were discharged to their homes after an average of 18 days in the hospital. During the first year another 61 (17%) patients returned home after rehabilitation in a geriatric ward. Of 446 patients walking without support or with one cane before surgery, 360 (80%) had regained the same mobility after one year. The one-year mortality rate was 18%, while the ten-year rate was 74%. Compared with a control cohort, the mortality rate was increased during the first two years after fracture. The increase in mortality was influenced by advanced age, admission from long-term care institutions, male gender, and ambulatory or nonambulatory status before surgery. Forty-five (7.4%) were reoperated, 17 because of technical complications, three because of infection, and three because of nonunion. No further nonunions occurred. The deep infection rate was nine of 339 (2.7%) before and two of 268 (0.8%) after the introduction of antibiotic prophylaxis. Thromboembolic complications decreased from 4.1% to 1.2% after the introduction of dextran 70 as thromboembolic prophylaxis.

Adult↗
PubMed1979

Serial quantitative electroencephalography.

Repeated EEG examinations are often used in diagnostically difficult cases to assess whether an EEG abnormality is progressive, regressive, or stationary. The conventional visual method is, however, poorly adapted to consider the variability when consecutive EEG recordings are compared. Using computer analysis of EEGs, the feature of the recordings as well as their variances can be measured, and the differences between the recordings can be tested statistically. The aim of the present study was to develop a practicable method for quantitative serial EEG examinations. Twenty EEGs from 5 volunteers were recorded to obtain reference data. The data acquisition was automated to obtain data without visual bias. The previously developed method using age ratios was employed for the primary analysis. The changes of the EEG activity during the observation period were evaluated statistically. Differences between consecutive EEGs could be observed even in normal subjects but the number of 'false positive' findings was reduced by the automatic data selection, by the choice of proper measures, and by adequate statistical treatment. The diagnostic value of the method was tested in 59 EEGs from 13 patients with well-defined brain disorders. Most EEG changes which could be attributed to the development of the disease were discovered and labelled as statistically significant.

Adult↗
PubMed1976

Radiographic measurements of the radio-carpal joint in normal adults.

Radiography of 60 normal wrists was performed in 50 adults to determine the inclination of the distal joint surface of the radius. The central ray was directed 10 degrees proximally in postero-anterior projection and 15 degree proximally in lateral projection. The values obtained were compared with those from perpendicular projections. No dfferences were found between the two p.a. projections. In the lateral projection with the central ray directed proximally the measuring points were better defined, resulting in significantly increased exactness of the measurement. The mean value for the volar inclination was 9 degrees in the latter projection.

Adult↗
PubMed1976

Radiographic measurements on the radio-carpal joint in distal radial fractures.

Radiography of 40 wrists with fractures in the distal part of radius was performed. In the lateral view the inclination of the radial joint surface was analysed in different degrees of pronation and supination. The central ray was directed 15 degrees proximally and the results were compared with those obtained with a perpendicular central ray. In the perpendicular projections even moderate differences in pronation or supination between two examinations could seriously alter the measured inclination of the joint surface of the radius. The projection with the central ray directed 15 degrees proximally highly significantly decreased the errors between the measurements when compared to the perpendicular projection. The joint surface was depicted more dorsally inclined than in the perpendicular projection.

Carpal Bones↗
PubMed1975

Partition of an organophosphorus compound, dichlorvos, between liquid and liquid crystalline phases.

The partition coefficients for an organophosphorus compound, dichlorvos (2,2-dichlorovinyl dimethyl phosphate), between pure liquids, micellar solutions, and liquid crystalline phases were determined by spectrometric analysis of the dichlorvos content after equilibration and separation of the phases. The results demonstrated the pronounced importance of associated colloid structures on the partition coefficient and showed that the partition coefficient did not display a simple concentration dependence.

Chemistry, Pharmaceutical↗
PubMed1975

Concanavalin A and other lectins in the study of tumor cell surface organization.

Cell surface structures of two mouse ascites tumors were studied using lectins. The tumors are sublines of the spontaneous mammary adenocarcinoma TA3 in strain A, differing in two main characteristics. Subline TA3-St grows only in syngeneic mice and has high expression of H-2 antigens. Subline TA3-Ha, in contrast, proliferates in all mouse strains, and has low amounts of exposed H-2 antigens. Concanavalin A (Con A), phytohemagglutinin (PHA) and Helix pomatia anti A hemagglutinin (HP) were used in agglutination tests, in binding experiments with 125I-labelled lectins and also in fluorescence studies with FITC-labelled lectins. Con A and PHA agglutinated the TA3-St cells but not the TA3-Ha cells. However, fluorescein-labelled Con A and PHA were bound to all cells (greater than 90%) of both sublines. Moreover both cell types contained an identical number of Con A receptors. The same result was obtained when the number of PHA receptors on the two sublines was compared. HP agglutinated TA3-Ha cells but not TA3-St cells. However, in this case, the difference in agglutinability between the lines was due to the presence or absence of HP receptors. All TA3-Ha cells contained large numbers of HP receptors. In contrast the majority (greater than 90%) of the TA3-St cells lacked HP receptors. (See article.) Trypsin released the HP receptors from TA3-Ha cells, at the same time making these cells agglutinable by both Con A and PHA. We conclude that the Ta3-Ha cells have a trypsin sensitive surface glycoprotein (or glycoproteins) detectable by HP, which is absent on most TA3-St cells. It is possible that this glycoprotein interferes with the agglutinability of TA3-Ha cells by Con A and PHA; whether it is also responsible for the low expression of H-2 alloantigen on this cell remains to be seen.

Adenocarcinoma↗
PubMed1975

The roentgenological end results after caliper treatment of coxa plana with varying degrees of epiphyseal involvement.

The radiological results after caliper treatment of 45 hips with Coxa Plana are presented. The material was grouped and analysed according to the degree of primary involvement of the epiphysis by the necrotic process. It was found that the risk for deformation of the femoral head became significantly higher in the groups with more extensive involvement of the epiphysis. This observation shows that the primary involvement of the epiphysis has a determining influence on the results. It further indicates that if the radiographic results from different materials of Coxa Plana are to be compared consideration must be given to the primary extent of necrosis of the epiphysis.

Child↗