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Biomedical subjects

S Friese

Publications and source records attributed to S Friese.

26 records · Page 2Linked to original sources

Prophylaxis in gynaecological surgery: a prospective randomized comparison between single dose prophylaxis with amoxycillin/clavulanate and the combination of cefuroxime and metronidazole.

A prospective randomized comparison of a single pre-operative dose of 2.2 g amoxycillin/clavulanate versus the combination of 1.5 g cefuroxime plus 0.5 g metronidazole was conducted in 467 women, who underwent gynaecological surgery. The incidence of febrile morbidity, urinary tract infection, wound infection and the use of post-operative antimicrobial agents was similar in the two groups. Amoxycillin/clavulanate is as effective as a combination of cefuroxime and metronidazole and less expensive.

Adult↗

Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.

A prospective randomized study was conducted comparing a single 2.2 g preoperative dose amoxycillin/clavulanic acid with a regimen of 1.5 g cefuroxim combined with 0.5 g metronidazole. Two hundred and fifty-one women were evaluated in this comparative study. The febrile morbidity, the incidence of urinary tract infections and the hospital stay were similar in both regimens. A single preoperative dose of amoxycillin/clavulanic acid was as effective as a combined regimen of cefuroxim and metronidazole and less expensive.

Adult↗

Abnormally adherent placentation: a life-threatening complication.

Two cases are presented illustrating the potential danger of abnormal placentation. Placenta accreta is frequently associated with placenta praevia and/or a history of previous caesarean section. As there are no obvious specific symptoms before or during delivery, one should consider the possibility of this anomaly in the third stage of labour when manual removal of the placenta is very arduous. The treatment of choice is immediate abdominal hysterectomy, for this is followed by the lowest maternal mortality. If abnormal placentation is suspected, one should be prepared to deal with it as necessitated, including the possible performance of an emergency caesarean hysterectomy.

Adult↗

Technical performance of the Elecsys CA 72-4 test--development and field study.

Tumor-associated glycoprotein (TAG) 72 is a mucin-like protein of high molecular weight (220-400 kd). Elevated serum levels of TAG72 are preferentially observed in patients suffering from gastric cancer. Additionally the determination of TAG72 may be a helpful tool in the management of patients suffering from mucinous ovarian cancer, in whom the clinical sensitivity of CA125 is low. The new Elecsys CA72-4 assay-available as Elecsys 2010 and 1010--was evaluated in a first field study. The test has a wide measuring range (300 U/ml) and low detection limit (0.5 U/ml) which favours its routine use. Typical precision values are 2% for intra-assay, 4% for inter-assay and 6% for inter-instrument-precision. Method comparisons to Enzymun-Test CA72-4 showed a correlation between 0.91 and 0.96. The correlation to a commercially available RIA was 0.8. With human ascites material no Hook-effect was observed up to 20,000 U/ml. No Hama-interference with clinically relevant HAMA-samples was detected.

Antigens, Neoplasm↗