Biomedical subjects

S Fuglsig

Publications and source records attributed to S Fuglsig.

9 recordsLinked to original sources

PubMed2000

[Villous adenoma of the rectum with electrolyte imbalance. McKittrick-Wheelock syndrome].

We present a case of villous adenoma of the rectum, associated with severe fluid imbalance in a 69 year-old, previously healthy woman. Severe dehydration with hyponatraemia, hypokalaemia, acidosis/alkalosis and watery diarrhoea is typical. Clinical presentation may include fatigue, confusion, convulsions or coma. Intensive rehydration is the primary intervention, and causal treatment is always surgery. Normally full recovery is achieved.

Adenoma↗

PubMed1996

[Spontaneous resolution of urodynamically proven sphincter lesion following surgery for prostatic hyperplasia].

Assuming that post-prostatectomy incontinence frequently resolves to various extents, forty patients from a background material of 105 consecutively referred patients with this complaint were reexamined three to 106 months (median 55 months) after first examination. During the time interval between first examination and the revisit only four patients had some improvement of their incontinence. Eleven patients were evaluated urodynamically at both occasions showing no change in MUCP (maximal urethral closure pressure) or other urodynamic parameters. Consequently we could not confirm the dogma that sphincter lesion due to prostate surgery may gradually resolve. Our investigation indicates a poor continence prognosis in patients incontinent after transurethral or transvesical surgery of the prostate and that there therefore should be a more active treatment attitude. The patients should be offered an operation after evaluation of their incontinence, when a sphincter lesion is first diagnosed.

Aged↗

PubMed1996

Identification of steroid receptors in human adipose tissue.

Steroids have the ability to alter adipose tissue distribution. Controversy exists as to whether these effects of sex hormones (oestrogen, progesterone and testosterone) on human adipose tissue are indirect or direct, as only very few studies have focused on steroid receptor status in human adipose tissue. In the present study, we reinvestigated steroid receptor status in human mature adipose tissue and human preadipocytes. Oestrogen, glucocorticoid and androgen receptors were found in human mature adipocytes from both women and men. The receptors were detected by ligand binding. Furthermore, the existence of the receptors was confirmed by demonstrating that adipocytes contained mRNA encoding the receptors. cDNA was generated using reverse transcriptase (RT) followed by polymerase chain reaction (PCR) amplification using specific primers (RT-PCR) for the specific steroid receptors. Adipocytes did not contain mRNA encoding the progesterone receptor (PR), and no progesterone binding was detectable in human adipocytes. Human preadipocytes contained glucocorticoid receptor (GR) mRNA and androgen receptor (AR) mRNA, whereas we were unable to detect oestrogen receptor (ER) mRNA and progesterone mRNA in human preadipocytes. In conclusion, oestrogen glucocorticoid and androgen receptors are present in mature adipocytes from subjects of both sexes, whereas adipocytes do not contain progesterone receptors. In preadipocytes, only glucocorticoid receptors and androgen receptors are present, whereas oestrogen receptors and progesterone receptors are not present.

Adipose Tissue↗

PubMed1995

The spontaneous course of urodynamically verified sphincter lesion after surgery for benign prostatic hyperplasia.

Assuming that post-prostatectomy incontinence frequently resolves to various extents, forty patients selected from a background material of 105 consecutively referred patients with this complaint were reanalysed 3 to 106 months (median 55 months) after first examination. During the time interval between first examination and the revisit only 4 patients had some improvement of their incontinence. Eleven patients were evaluated urodynamically at both occasions showing no change in MUCP or other urodynamic parameters. Consequently we could not confirm the dogma that sphincter lesion due to prostate surgery may gradually resolve. Our investigation indicates a poor continence prognosis in patients incontinent after transurethral or transvesical surgery of the prostate and a more active treatment attitude. The patients should be offered an operation after evaluation of their incontinence, when a sphincter lesion is first diagnosed.

Aged↗

PubMed1995

Percutaneous nephroscopic resection of renal pelvic tumors.

During a 7 1/2 years period 31 patients representing 32 renal units presented with filling defects of the renal pelvis at excretory urography. All were treated with percutaneous resection of the pelvis. In 26 renal units there was histologic evidence of transitional cell tumor of varying grade and stage. With a follow-up from 4 to 79 months 8 recurrences including 1 case of tract tumor implant were seen. No other serious procedure related or later complications have appeared. The indications for using the percutaneous approach are discussed, and the results according to grade and tumor-stage are presented. Percutaneous resection of renal pelvic transitional tumors is recommended for low grade, non-invasive tumors, and for carefully selected patients with superficially invasive tumors.

Aged↗

PubMed1994

Survival after transurethral resection of the prostate: a 10-year followup.

Among 141 men who underwent transurethral resection of the prostate from late 1979 to early 1980 followup for 10 years was done, registering total mortality rate and individual dates of death. The mortality of the group was compared to an age-matched group from the background population of men for each of the 10 years. During the observation period the mortality of the group as a whole as well as that of the patients 65 years old or older at operation were equal to that of the background population at all times. Withholding recommendation of transurethral resection of the prostate in favor of other types of prostatic surgery on the grounds of a higher long-term mortality rate is not supported by our material.

Aged↗

PubMed1994

Total transurethral resection versus minimal transurethral resection of the prostate--a 10-year follow-up study of urinary symptoms, uroflowmetry and residual volume.

OBJECTIVE: To assess the long-term results of total transurethral resection (T-TURP) and minimal transurethral resection of the prostate (M-TURP) in patients with obstructive symptoms caused by benign prostatic hyperplasia. PATIENTS AND METHODS: Between September 1979 and September 1980, 167 patients were studied: 83 were randomized to T-TURP and 84 to M-TURP. The patients were examined pre-operatively and 6 and 12 months post-operatively. Ten years post-operatively they were invited to attend for further examination, including uroflowmetry, determination of residual volume and evaluation of subjective symptoms. RESULTS: At the 10-year follow-up 39 patients were found to have died and 47 were lost to follow-up. Twelve patients had undergone repeat TURP and seven had been treated for urethral stricture. Thus 33 T-TURP and 29 M-TURP patients underwent detailed examination. Significant relief in obstructive and irritative symptoms was seen in both groups. The improvement in maximum flow rate remained stable throughout the follow-up period, with no significant differences between the two groups. Post-void residual urine decreased throughout follow-up, with minor differences between the groups. CONCLUSION: M-TURP is recommended as an alternative to T-TURP.

Adult↗

PubMed1991

[Intussusception in children].

The records of 22 children (sex rate boy/girl 1.75, mean age 2 7/12 year) treated for intussusception in Randers Central Hospital during the period 1975-1989 were reviewed. In 27% of the cases this diagnosis was made before admission, gastroenteritis being the most frequent differential diagnosis (18%). The mean duration of symptoms before admission was 24 hours. No significant correlation between low age and late diagnosis was found. Symptoms were vomiting (100%), abdominal colic (95%), palpable abdominal tumour (73%), diarrhoea with blood and mucus (63%) and low-grade fever (64%). Treatment by barium enema had a low success-rate (29%); the best results were recorded in children with symptoms for less than 24 hours. The mean duration of the hospital stay was 3.5 days in children treated by barium reduction and 8.5 days in children treated surgically. Early diagnosis seems to increase the success-rate of non-operative treatment. Absence of the classical triad of paroxysmal pain, abdominal mass and red currant jelly stool (found in 41% of the cases) does not exclude the possibility of intussusception.

Adolescent↗

PubMed1990

[Postoperative synergistic infection].

Two cases of synergist postoperative infection are described. The importance of radical wound toilet and broad-spectrum antibiotic treatment is emphasized. Synergist infection should be borne in mind in cases where postoperative wound infection continues to spread despite thorough wound toilet.

Adult↗