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Biomedical subjects

S Furuichi

Publications and source records attributed to S Furuichi.

35 records · Page 2Linked to original sources

[Two cases of cerebral aneurysm detected after recanalization of the middle cerebral artery].

Two cases of aneurysm incidentally detected after recanalization of middle cerebral artery (MCA) occlusion are reported. Patient 1 was a 62-year-old male with sudden onset of left hemiparesis. We performed emergent intravascular surgery. The initial cerebral angiography revealed occlusion at the M1 portion of the right MCA. After partial recanalization with a microcatheter, carotid angiography revealed a right M1-M2 junction aneurysm. Due to the risk of aneurysmal rupture, the thrombolytic procedure was stopped. Follow up angiography after 1 month revealed complete recanalization of the right MCA and a persistent aneurysm. Patient 2 was a 65-year-old male with left hemiparesis. The initial cerebral angiography revealed occlusion at the M1 portion of the right MCA. After 1 month follow-up cerebral angiography revealed spontaneous recanalization of the right MCA and an incidental aneurysm at the M1-M2 junction. Neck clipping of the aneurysm was performed. When using a microcatheter or microballoon catheter to treat arterial occlusion, surgeons should consider the possibility of a rupture of a hidden aneurysm.

Aged↗

Primary choroid plexus papilloma of the foramen magnum--case report.

A 50-year-old male presented with a choroid plexus papilloma in the foramen magnum manifesting as dysesthesia in the right hand and severe headache. Magnetic resonance imaging clearly showed that the tumor was located in the cerebellomedullary cistern, without extension into the fourth ventricle. However, differentiation from hemangioblastoma or foramen magnum tumor was difficult by neuroimaging. Intraoperative observation found the tumor was located extraventricularly and attached to the choroid plexus of the foramen of Magendie. The tumor was grossly totally resected. Histological examination proved the tumor was a choroid plexus papilloma without malignancy. His neurological deficits resolved almost completely.

Choroid Plexus↗

Effects on iontophoretically applied acetylcholine on membrane potential and synaptic activity of bulbar respiratory neurones in decerebrate cats.

Intracellular recordings were made from bulbar respiratory neurones of decerebrate cats, together with iontophoretic application of acetylcholine and its specific antagonists to assess cholinergic mechanisms involved in the central respiratory network in vivo. Of 126 respiratory-related neurones impaled in the ventral respiratory group, iontophoresis of acetylcholine produced depolarization in 67 cells (53%), hyperpolarization in 36 cells (29%), and no effect in the remaining 23 cells (18%). Depolarization occurred predominantly in laryngeal motoneurones (31/40) and bulbo-spinal neurones (4/5), while a comparable number of non-antidromically-activated respiratory neurones displayed either depolarization (33/81) or hyperpolarization (31/81). Acetylcholine had no significant effect on excitatory and inhibitory postsynaptic potentials in all types of neurones tested. Both depolarizing effects of acetylcholine were antagonized by co-iontophoresis of atropine, but not by hexamethonium. Input resistance was increased (7/9) or unchanged (2/9) in depolarized cells, whereas it was unaltered in all hyperpolarized cells tested (n = 6). The present results suggest that the distribution and functions of cholinergic muscarinic receptors are different for the laryngeal and bulbo-spinal types of respiratory neurones and the non-antidromically-activated respiratory neurones in the cat.

Acetylcholine↗

Clinical study of enlarged infundibular dilation of the origin of the posterior communicating artery.

Although some aneurysmal dilations of the origin of the posterior communicating artery (PCoA) that are revealed on carotid angiogram are true aneurysms or preaneurysmal lesions, the authors warn that diagnosis should not be based only on the size and shape of the dilation, especially when the PCoA does not fill. In the present retrospective study, the authors analyzed intraoperative and angiographic findings in 32 patients with 34 lesions of the PCoA that were preoperatively diagnosed as aneurysms. Only 10 of the lesions were true aneurysms (six cases) or enlarged infundibular dilations with reddish bulges (that is, preaneurysmal bulge; four cases) at the origin of the PCoA. All of the other 24 lesions, including one lesion with PCoA occlusion, were merely enlarged infundibular dilations without any wall abnormality. A well-developed PCoA was observed only in cases of true aneurysm and dilation with reddish bulge. No other clinical or angiographic characteristics proved useful in identifying the type of lesions. These findings may be helpful to the physician in evaluating the clinical features of such lesions and in determining the diagnosis of enlarged infundibular dilation of the PCoA.

Aged↗

[Dilated lesion at internal carotid artery posterior communicating artery junction].

The diagnosis and surgical indication of an incidental aneurysm at the IC-PC junction is sometimes vague. In this report, 28 lesions in 26 cases with aneurysmal dilatation at the IC-PC junction, which were surgically treated, were analyzed. These lesions are classified according to the operative findings. Only 6 of the lesions were confirmed to be true aneurysms. However, 19 lesions were the dilated changes of the posterior communicating arteries (Pcom) themselves, without aneurysmal formation. Two lesions were accompanied with blood blister like aneurysm at the wall. Another one was dilated Pcom with peripheral Pcom occlusion. The correlation between operative findings and angiographic findings are studied, and the importance of the diagnostic angiographic findings of the Pcom is strongly emphasized for their diagnostic value.

Adult↗

[A case of intraventricular cyst associated with normal pressure hydrocephalic condition].

A case of intraventricular cyst associated with normal pressure hydrocephalic condition (NPHC) is reported. A 72 year-old female, with 2-year-history of slowly progressing dementia and gait disturbance, was admitted to our hospital on September 19, 1989. On admission, she had mild dementia, unsteadiness of gait, and at times urinary incontinence. Cerebrospinal fluid (CSF) pressure was found to be 90mmH2O by lumbar tap. Plain computed tomographic (CT) scan and T1-weighted magnetic resonance image (MRI) showed asymmetrical enlargement of the trigon and posterior horn of the right lateral ventricle. CT cisternography showed a cyst in the trigon and in the posterior horn of the right lateral ventricle. T1-weighted MRI with Gd-DTPA demonstrated no enhancement of the cyst wall, and there was superior and posteromedial displacement of the choroid plexus at the trigon of the right lateral ventricle. The patient was diagnosed as having an intraventricular cyst in the right trigon with NPHC. Ventriculo-peritoneal shunt and partial removal of the cyst were performed. Histological examination of the cyst wall revealed collagenous strands and no epithelial cells. Developmental intracranial cysts, especially arachnoid or ependymal cysts, occasionally lack an epithelial layer, so their histological diagnosis is difficult. This case was considered to be an arachnoid cyst because there was adhesion between the cyst and the choroid plexus in the right trigon, and superior, posteromedial displacement of the choroid plexus, which indicated extension of the cyst from the extracerebral to the intracerebral region. NPHC was considered to be due to disturbance of CSF circulation caused by gradual expansion of the cyst.

Aged↗

[A disproportionately large communicating fourth ventricle occurring after suboccipital craniectomy: report of two cases].

Two cases of a disproportionately large communicating fourth ventricle (DLCFV) which developed after suboccipital craniectomy are reported. The first case was that of a 43-year-old female who sustained subarachnoid hemorrhage, and the second case was that of a 12-year-old male with medulloblastoma. Patency of the aqeductal canal and occlusion of the fourth ventricle outlets were demonstrated in both cases by metrizamide ventriculography, with intraventricular injection of contrast material. Clinical history was analyzed with repeated CT scan, and pathogenesis of DLCFV was discussed with review of the literature.

Adult↗

[An elderly case of recurrent craniopharyngioma suffering from hemorrhage].

A case of a 63-year-old female with craniopharyngioma is reported. She first suffered from occult pituitary apoplexy and had recurrent enlargement and characteristic changes of a tumor during short periods. This patient was hospitalized after suddenly developing bitemporal hemianopsia. An intra-and suprasellar hematoma was revealed on computed tomography (CT) and magnetic resonance imaging (MRI). At the first operation, the hematoma was removed totally by the transsphenoidal approach, but tumor tissues were not identified. During the following 12 months, operations were repeated three times due to the recurrence and/or enlargement of a tumor associated with visual symptoms. Pathological diagnosis was squamous-type craniopharyngioma without any malignancy. Microscopic appearance of the tumor apparently changed during the clinical course. The characteristic findings were revealed respectively on MRI and CT. On the first preoperative MRI, a lesion of diffuse high signal intensity was observed on both T1 and T2 weighted images. At the second operation, the lesion was also revealed as having high signal intensity on T1 and T2 weighted images but the tumor had a large cyst with serous-yellowish fluid contents. A differential diagnosis was made on CT. At the third and fourth operations, the tumor was solid and had atheromatous contents. The lesion was revealed as having low signal intensity on T1 image and high on T2 respectively. Occult pituitary apoplexy with intra and suprasellar hemorrhage is very rare in cases of craniopharyngioma and only nine cases have been reported until now. It is also interesting with this high-aged patient that repeated recurrence and/or enlargement of a tumor with different microscopic appearances occurred during such short periods.(ABSTRACT TRUNCATED AT 250 WORDS)

Craniopharyngioma↗

Changes in the FDP (fibrin and fibrinogen degradation products) value under mental and physical stress. I. Changes in FDP and other indices of physio-biochemical effects of stress loaded on volleyball players during training.

It has been known that CA change during physical exercises and associate with dynamic aspects of the coagulation fibrinolysis system of the blood. Therefore, we studied fibrin and fibrinogen degradation products (FDP) under physical exercises together with LDH, CPK, LA, CRE, Na, K and P. 1) College students of Department of Education majoring in sciences of physical education significantly increased activities of CPK and LDH during the training for volleyball games compared with the pre-training values. This increment was remarkable for those who exercised hard, that is, who were loaded with large physical stress. 2) Changes in LA were included in the range of its normal values. Freshmen who had not been trained much and consequently whose adaptability for physical stress was insufficient increased the LA level significantly relative to the pre-training level. 3) Although changes in P were included in the range of its normal values, significant increase was observed by physical stress. Examinations by individual disclosed that a tendency of changes in P was similar to that in CPK and FDP. 4) The tendency of changes in FDP agreed with that in CPK and P and an increase was observed for those who were loaded with large physical stress. It was further observed that especially for those who were loaded with large mental stress together with physical stress the increase in FDP was evident. Therefore, it has been suggested that FDP can be used as an index of biotic effects of not only physical stress but also mental stress.

Adult↗

Changes in the FDP (fibrin and fibrinogen degradation products) value under mental and physical stress. II. Simultaneous observations of FDP and other indices of fatigue in persons under experimentally loaded stress.

We assumed the possibility of adopting FDP as an index of fatigue and carried out examinations upon various load conditions causing stress. For our observations other indices which are thought effective for fatigue evaluation, such as urine CA, flicker values, response time, Uchida's Kraepelin test, and examination of subjective symptoms recommended by the Japan Association of Industrial Health, were adopted at the same time. 1) Both mental and physical loads increased FDP values both in serum and in urine. 2) These changes in FDP values agreed comparatively well with the changes in CA by load. 3) The FDP value showed changes by load which was so light that it did not induce functional deterioration detectable by the response time or the flicker value which was considered to be one of effective physiological indices. 4) The extent or degree of subjective symptoms found by the survey agreed well with the changes in FDP values. Through above examinations, FDP values of serum and urine seem to be useful as an index of transient fatigue; especially they can well reflect mental fatigue which cannot be indicated well by other biochemical indices. Also FDP can well show individual characteristics, namely FDP indicates comparatively satisfactorily both individual sensitivity and specificity. Furthermore, this method does not require special techniques and examinations can be done simply.

Adult↗