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Biomedical subjects

S Furuya

Publications and source records attributed to S Furuya.

At least 163 records · Page 9Linked to original sources
PubMed1983

A quantitative analysis of intramembranous particles during the development of neuroblastoma X glioma hybrid cells.

The process of neural differentiation of neuroblastoma X glioma hybrid cells (NG108-15 cells) was studied by freeze-fracture electron microscopy. The distribution of intramembranous particles (IMPs) was random and their density increased in both P-, and E-face of the plasmalemma when the membrane excitability developed. Undifferentiated cells grown in growth medium for 2-6 days had an average of 1300-1500 IMPs/micron2 in the P-face and 250-300/mu 2 in the E-face. After the cells were differentiated with dBcAMP for 1 week, the density of IMPs was 2600/micron2 in the P-face and 540/micron2 in the E-face. The analysis of size distribution showed the increase of the number of medium (7.5-10 nm) and large (greater than 10 nm) particles. The slight increase of large particles was observed in the case of differentiated N18TG2 (the parental neuroblastoma clone) cells. Treatment with dBcAMP did not affect the number and the size distribution of IMPs in the C6BU1 (the parental glioma clone) cells.

Animals↗
PubMed1983

Occurrence of actinlike microfilaments in the outer root sheath cells of the hair follicle: a possible role of a cytoskeleton.

Broad bundles of actinlike microfilaments are found in the basal cells of the outer root sheath of the hair follicle. The filaments react specifically with heavy meromyosin to form a fuzzy structure, and disappear from the cells after the actin depolymerization treatment. An array of the filament bundles alters along with the cell shape changes of the basal cells. In the flattened cells of the hair follicle bulb, the bundles appear to run parallel to the long axis of the cells, and are present in the basal cytoplasm. In the cuboidal cells of the suprabulbar and the more superficial portion of the follicle, the bundles are perpendicular to the basal plasma membrane, and are disposed mainly in the basal cytoplasm. The microfilaments are associated with the basal plasma membrane directly or via insertion into the plaque of the membrane, where filamentous or amorphous materials link the membrane and the basal lamina. In vitro treatment of cytochalasin B for up to 8 hr causes no visible change in the distribution pattern of the bundles nor abnormal changes in the cell shape. Thus, the actinlike microfilament bundles appear to provide a cytoskeletal system responsible for the maintenance of the cell shape change, since they are disposed in the direction and area in which a maintenance force for the cell shape change may be required, and other cytoskeletal systems of the cells such as microtubules and tonofilament-desmosome complexes are poorly developed, and no hemidesmosomes are present in the cells.

Actins↗
PubMed1983

[Urodynamic studies on postmicturition dribble].

Sixteen patients presenting with a symptom of postmicturition dribble were studied. All the patients were examined by the technique of voiding cysto-urethrography recording on video-tape. The findings of the videocysto -urethrography confirmed that postmicturition dribble resulted from a residue of urine in the bulbar urethra. No urodynamic abnormality was seen in the six patients who had no other symptom or disease. The patient is instructed to compress the bulbar urethra manually in the perineum after micturition and evacuate the bulbar residual urine. Symptomatic relief is usually obtained.

Adult↗
PubMed1982

Alpha-adrenergic activity and urethral pressure in prostatic zone in benign prostatic hypertrophy.

In order to examine to what extent adrenergic mechanism contributes to the urethral pressure in patients with benign prostatic hypertrophy, changes in the intraurethral pressure in the prostatic zone were measured in vivo by both the urethral pressure profile technique and the balloon method before and after administration of alpha-adrenergic stimulants and an alpha-adrenergic blocker. The effect of spinal anesthesia on the urethral pressure was also investigated. It is suggested that 40 per cent of the total urethral pressure in patients with benign prostatic hypertrophy is due to alpha-adrenergic tone, and the remaining 53 per cent is due to static pressure resulting from the hypertrophied prostatic bulk. The in vitro study indicates that the increase in urethral pressure and contraction of the prostate, prostatic capsule and prostatic urethra.

Adrenergic alpha-Agonists↗
PubMed1980

Circadian rhythmicity in several small intestinal functions is independent of use of the intestine.

Fifty milliliters of a liquid diet were administered daily to rats in three different ways: 1) orally, beginning at 0000 h; 2) by continuous intravenous infusion; and 3) by discontinuous intravenous infusion from 0000 to 1400 h. Animals were killed every 6 h over a 24-h period. Activity profiles as a function of time of day were determined for the following small intestinal parameters; monosaccharide transport; five disaccharidases; alkaline phosphatase; gamma-glutamyltransferase; leucylnaphthylamide hydrolyzing activity; villus height and width; and number of columnar cells lining a villus section. Circadian rhythmicity as previously reported was observed for all parameters in rats fed orally for 7 days but was not observed in any parameters in rats fed by continuous infusion for 9 days. Rats fed by discontinuous infusion for 10 days maintained circadian rhythmicity in the following functions: monosaccharide transport; disaccharidase activities; and columnar cell number. Thus, rhythmicity in these functions can exist without nutrient delivery to the alimentary tract and presumably arises from involvement of a neuro-endocrine component. The other activities tested appear to require the alimentary tract for the existence of circadian rhythmicity.

Administration, Oral↗
PubMed1980

Blood-testis barrier in men with idiopathic hypogonadotropic eunuchoidism and postpuberal pituiary failure.

Immature-type Sertoli cells in the testes of idiopathic hypogonadotropic eunuchoidism (17-30 years of age) had no specialized junctions. The specialized Sertoli junctions that blocked the penetration of lanthanum were formed six months to two years after hCG treatment (5000 IU twice a week) in patients of hypogonadotropic eunuchoidism. In two patients with postpubertal pituitary failure (one had a ectopic pinealoma, irradiated one year ago, and the other had a pituitary adenoma, hypophysectomized four years ago), the ultrastructural integrity of these Sertoli junctions was maintained. Therefore, it may be suggested that the development of the blood-testis barrier is dependent on gonadotropins, but the maintenance of the blood-testis barrier is not.

Adenoma↗
PubMed1978

Fine structure and development of Sertoli junctions in human testis.

Complicated interdigitation-like junctions between the immature Sertoli cells were frequently observed in prepubertal testis (3--8-year-old). Tight or gap junctions could not be found. Subsurface cisternae appear in the testes of 7 and 8-year-old boys. In pubertal testis (11 to 13 years old), junctional specializations between Sertoli cells are composed of membrane fusions, bundles of microfilaments and associated cisternae. These tight junctions block the deep penetration of lanthanum into the seminiferous tubules. The lanthanum-filled Sertoli junctions show characteristic features of membrane fusions. In the seminiferous tubules spermatocytes were not present at 11 years of age but complete spermatogenesis was noted at 12-13 years of age. It is suggested that the human blood-testis barrier is estabilished shortly before or after the spermatogonia proliferate to give rise to primary spermatocytes.

Adolescent↗