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Biomedical subjects

S G Ciancio

Publications and source records attributed to S G Ciancio.

At least 19 recordsLinked to original sources
PubMed1992

Agents for the management of plaque and gingivitis.

Numerous chemical agents have been evaluated for the supplementation of patient-dependent mechanical plaque control and thus the reduction or prevention of oral diseases. Agents discussed in this paper are those most frequently evaluated in recent studies and include chlorhexidine, essential oils, triclosan, sanguinarine, fluorides, oxygenating agents, quaternary ammonium agents, prebrushing rinses, enzymes, and antibiotics. Of the agents discussed, the greatest effect on the reduction of plaque and gingivitis can be expected from chlorhexidine, essential oils, and triclosan-containing products. These chemical agents vary in dosage form and include mouthrinses, gels, and dentifrices. Some may also be of value as irrigants. Adverse effects vary according to the chemical agent and include poor taste, burning sensation of oral tissue, staining of teeth and soft tissues, excess supragingival calculus, oral lesions in young patients, and allergic reactions. When a product is selected for a patient, consideration should be given to necessity, efficacy, adverse effects, and cost-effectiveness.

Anti-Infective Agents, Local↗
PubMed1992

Tissue concentration and localization of tetracycline following site-specific tetracycline fiber therapy.

The primary objective of this study was to evaluate the concentration and location of tetracycline hydrochloride in tissue adjacent to periodontal pockets treated with a tetracycline impregnated fiber. A secondary objective was to determine if the presurgical placement of fibers had any adverse effects on healing following periodontal surgery. The study population consisted of 10 patients with at least 2 pockets in both maxillary quadrants of > or = 5 mm in depth and exhibiting bleeding on probing. After an initial scaling and root planing, placebo or tetracycline fibers were randomly assigned by quadrant to 2 non-adjacent pockets. Fibers were removed at the time of surgery; i.e., day 8, and periodontal surgery was performed utilizing a flap incision that allowed biopsy of 1 interdental papilla from each of the 2 test sites in each quadrant. One biopsy was analyzed for tetracycline concentrations by high performance liquid chromatography (HPLC). The second biopsy was examined by both light and ultraviolet fluorescence microscopy to determine the location of residual tetracycline and the intensity of inflammatory cell infiltrates. Results showed that the tissue concentration of the antibiotic in tetracycline treated sites was 64.4 +/- 7.01 ng/mg (ng of tetracycline/mg tissue weight) which corresponds to 43 micrograms of tetracycline and was below levels of accurate measurement in placebo treated sites. Tetracycline tissue concentrations corresponded to the ultraviolet fluorescence microscopy with a Pearson correlation coefficient of r = 0.92. Tetracycline fluorescence was noted in the soft tissue wall ranging from 1 to 20 microns.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Subgingival delivery by an oral irrigation device.

Irrigating devices have been incorporated into numerous oral hygiene regimens. Newer types of these devices are designed to deliver irrigating solutions directly into the periodontal pocket. We examined the ability of a powered irrigating device with a soft rubber tip to deliver subgingivally into periodontal pockets. When subgingival irrigation was used, the mean pocket penetration was 90% of the pocket depth (less than or equal to 6 mm) compared to a mean of 21% in the oral rinse group. The irrigation was not uncomfortable to patients.

Dental Equipment↗
PubMed1991

Local anesthetics.

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Anesthesia, Dental↗
PubMed1991

Detection and management of the high risk periodontal patient.

Periodontal diseases and patients at risk for progression of disease can be diagnosed on the basis of age, previous episodes of periodontal disease and loss of attachment, as detected by periodontal probing and radiographic evaluation. For early onset periodontitis, family history may be important. Microbiological evaluations are excellent determinants of disease and also appear to be probable predictors of 'at risk' patients. Reliable tests, including chairside tests, are available for the three most probable pathogens: Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia. Biochemical changes, although associated with various disease states, are not yet readily measurable at the chairside, with the exception of one test that measures aspartate aminotransferase and shows promise as a detector and predictor of periodontal disease. The diagnosis and 'at risk' prediction of periodontal disease is based on a number of criteria, some of which are highly reliable and others whose reliability is either probable or unclear. These criteria are reviewed with emphasis on those that may be indicative of the patient at high risk of developing periodontal disease or progressing to a more severe form of disease.

Disease Susceptibility↗
PubMed1990

Reviewing nonsurgical periodontal therapy.

Selection of the appropriate case and clinical competency in treatment modalities results in success in nonsurgical periodontal therapy. The patient with early periodontitis with significant local factors in the form of professionally accessible plaque and calculus is the most receptive to nonsurgical periodontal treatment. The clinician must make decisions centering around the important question, "Can the patient, or moreover, can the therapist delivering the debridement, gain access to the microbial subgingival plaque on a frequent basis below the host defense threshold of the respective patient?" If the answer is "yes," nonsurgical periodontal therapy will be rewarding. If the answer is "no," other modalities such as periodontal surgery must be instituted.

Dental Plaque↗
PubMed1990

Opioid analgesics.

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Analgesics, Opioid↗