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Biomedical subjects

S G Dzagurov

Publications and source records attributed to S G Dzagurov.

At least 19 recordsLinked to original sources
PubMed1984

Immune response to different tick-borne encephalitis vaccines as revealed by lymphocyte blast transformation and virus neutralization tests.

Immunological memory has been demonstrated in lymphocytes of persons vaccinated against tick-borne encephalitis (TBE). Stimulation indices (SI) of lymphocytes in response to TBE virus antigens in lymphocyte blast transformation test increased after complete vaccination course with the commercial vaccine; by this time, sera of vaccinees contained virus neutralizing antibodies. The concentrated purified vaccine had a higher immunogenic activity, as evidenced by increased SI and virus neutralizing antibodies (NA) in the vaccinated subjects already after the first and second vaccinations.

Adolescent↗
PubMed1984

[Current problems of immunoprophylaxis of infectious diseases and standardization of medical immunobiological preparations].

The state of immunoprophylaxis in the whole of the USSR and in individual Union Republics in 1981-1982 is ralyzed. The connection between an increase in diphtheria, pertussis and measles morbidity and the widening of the scope of contraindications to vaccination has been revealed. The optimum vaccination tactics in Union Republics with regard to differences in their climatic conditions and demographic situation is planned. The problems of the standardization of prophylactic and therapeutic immunobiological preparations are considered. Organizational measures leading to the improvement of their quality are outlined.

Humans↗
PubMed1983

A study of candidate rabies vaccines for a national reference preparation for the evaluation of antigenic potency.

An unconcentrated and a concentrated lot of rabies vaccine prepared in Syrian hamster kidney cell culture from the Vnukovo-32 strain have been examined for their suitability as national reference preparations for rabies vaccine. The antigenic potencies of the preparations were assessed by the NIH test using both fixed and street strains of rabies virus and by the method of antibody induction. The candidate vaccines were calibrated in comparative assays with the WHO 3rd International Reference Preparation of Rabies Vaccine (IRP3). The correlation between the level of virus-neutralizing antibody and the resistance of mice to intracerebral challenge with a fixed rabies virus strain was studied. The candidate vaccines were also examined by the thermal degradation test. It was found that both vaccines had appropriate antigenic potency and thermostability to be used as a national reference preparation of rabies vaccine.

Animals↗
PubMed1983

Blastogenic lymphocyte response as indicator of cell-mediated immunity in humans vaccinated with live and inactivated influenza vaccines.

The level and dynamics of lymphocyte blastogenesis in response to phytohaemagglutinin (PHA) and to specific influenza virus antigen were studied in 3 groups of humans, vaccinated with live or inactivated whole virion influenza vaccines (H3N2 type) and placebo (control group). Both live and inactivated influenza vaccines did not change significantly the functional activity of T lymphocytes as determined by the mean values of stimulation index (SI). The analysis of individual values of PHA-dependent blastogenic response, however, revealed a decrease in SI as compared with its prevaccination level in 33.3 +/- 11.4% of the vaccinees given the live influenza vaccine.

Adolescent↗
PubMed1983

[Evaluation of the toxic action of prophylactic and therapeutic preparations on cell cultures. III. The detection of toxic properties in medical biological preparations by the degree of cell damage in the L132 continuous cell line].

The methods of the quality control of medical biological preparations, including tests on animals, do not ensure the complete absence of toxicity in a final product. The use of the method of "subcultures with the introduced preparation" makes it possible to determine the toxicity of both specific and nonspecific components of vaccines and sera from the number of dead and damaged cells. The toxic action of preparations kills and damages the cells at the site of injection, thus inducing the formation of autoantigens whose effect on the body cannot be predicted. Thus thimerosal, commonly used as preservative, has been found not only to render its primary toxic effect, but also capable of changing the properties of cells. This fact suggests that the use of thimerosal for the preservation of medical biological preparations, especially those intended for children, is inadmissible.

Allergens↗
PubMed1982

[Immunodepressive action of vaccinia virus].

The hemolytic plaque test in mice was used to demonstrate that live vaccinia virus has marked immunosuppressant action. Inactivated vaccinia virus produces no such an effect and even stimulates the output of the antibody-forming cells. The experimental data were found to be statistically significant.

Animals↗
PubMed1979

[Effect of small doses of diphtheria exotoxin on cell cultures].

High diphtheria exotoxin concentrations induced irreversible injuries to all the cultures under study (L, HeLa, spcv pzM). However, its final titres in the mentioned cells differed. HeLa and pzM cells, being highly sensitive, can be recommended for titration of dipheria exotoxin, instead of the expensive guinea pig tests. Low (subtoxic) doses produced cytoproliferative action and caused changes of the cell properties.

Animals↗
PubMed1977

[Modification of chromosome aberrations caused by kilham virus in rat embryo cells].

Mutagenic effect of Kilham virus on the frequency of chromosome aberrations in the cells of primary and continous rat embryo cultures and the modification effect of cadmium salt on the mutagenic potential of this virus was studied. The frequency of chromosome aberrations increased in the primary rat embryo culture after Kilham virus enfection. Rat embryo culture chronically infected with Kilham virus did not differ from control continuous cells in the frequency level of chromosome aberrations. Isertion of cadmium in the process of cultivation increased the mutagenic effect of kilham virus in the primary rat embryo culture.

Animals↗
PubMed1977

[Protection of inventions in the field of vaccines and sera].

Requirements admit a possibility of protection of a vaccine-serum preparation by the author's certificate only in case of approbation of the preparation. The formula of invention should describe the preparation in such a way that it could be differentiated from similar preparations. In accordance with these requirements the preparation can be described only with reference to the method of obtaining it, since this method determines its quality. The most rational form of protection of suggestions in the field of vaccines and sera is a complex protection of the preparation and of the method of obtaining it. Protection of the method of obtaining the preparation alone limits the authors' rights.

Immune Sera↗
PubMed1976

Phenotypic mixing of vesicular stomatitis virus and D-type oncornavirus.

After mixed infection of cells with vesicular stomatitis virus (VSV, thermolabile mutant tl 17) and oncornavirus type D, phenotypically mixed virions are formed containing the VSV genome and oncornavirus and VSV envelope. The virions are thermostable and have serologic characteristics of both viruses.

Animals↗