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Biomedical subjects

S G Kushner

Publications and source records attributed to S G Kushner.

5 recordsLinked to original sources
PubMed1978

[Quantitative assessment of antithymocyte antibodies in schizophrenia].

The use of the method of fluorescent antibodies and cytotoxic tests showed that the blood serum of schizophrenic patients and normals possess an antithymocytic activity. However, the level of this activity in patients exceeds the corresponding indices in normals (p less than 0.02). The use of indirect immunofluorescent methods permitted to demonstrate that the antithymic antibody titres in schizophrenic patients is much higher than in normals. The amount of the cytotoxic index is in direct correlation with the level of antithymic antibodies determined by the fluorescent antibody method.

Adult↗
PubMed1977

[Results of a comparative study of anti-brain antibodies in the sera of healthy subjects and schizophrenic patients by the Coon's indirect immunofluorescent method].

With the aid of the Coombs indirect method the authors studied the blood sera of 79 patients with different forms of schizophrenia and 27 normal donors. It was demonstrate that the blood sera of schizophrenic patients and normals contain globulins capable of fixation on different components of a nervous cell. However, the character and intensity of fluorescence as well as the amount of fluorescent nerve cells in the field of vision distinguishes the examined patients from normal donors.

Autoantibodies↗
PubMed1976

Studies on human brain-thymus cross-reactive antigens.

Antigens shared by human brain and thymocytes and by human and mouse tissues were studied with rabbit anti-human thymocyte antiserum (RAHT). It was found that cytotoxicity of RAHT serum against mouse thymus cells was not absorbed by mouse liver or bone marrow cells. Human brain and thymus cells completely absorbed the anti-thymocyte activity from this antiserum. It was suggested that human brain had antigenic determinants identical or very similar to those found on human thymocytes. Activity of RAHT antiserum against mouse thymus cells was completely removed by an absorption of mouse brain and thymocytes. These results demonstrated that there were shared antigenic determinants between human and mouse tissues.

Adult↗