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S G Subbuswamy

Publications and source records attributed to S G Subbuswamy.

At least 19 recordsLinked to original sources
PubMed1999

A case of ureteric obstruction, retroperitoneal fibrosis, and carcinoid tumour.

We report the incidental finding at surgery for retroperitoneal fibrosis of a carcinoid tumour causing complete right ureteric obstruction. Retroperitoneal fibrosis is an uncommon inflammatory disease that leads to extensive fibrosis throughout the retroperitoneum. It can occur at any age, peak incidence being in patients between 40 and 60 years of age. Carcinoid tumours arise from enterochromaffin or amine precursor uptake and decarboxylation cells that occur in gastrointestinal tract. Carcinoid tumours are an uncommon clinical entity and incidence varies with gender and age. No association between retroperitoneal fibrosis and carcinoid tumour has been previously reported in the English literature, although one case has been reported in a French journal.

Carcinoid Tumor↗
PubMed1986

Cytokeratin and laminin immunostaining in the diagnosis of cutaneous neuro-endocrine (Merkel cell) tumours.

Nine cutaneous neuro-endocrine tumours have been immunostained with monoclonal antibodies to low molecular weight cytokeratin (CAM 5.2) and neurofilament. Polyclonal antisera to neurone-specific enolase, calcitonin and laminin were also used. All nine cases showed paranuclear, dot-like positive staining with CAM 5.2 and diffuse cytoplasmic staining for neurone-specific enolase. Neurofilament and calcitonin immunoreactivity could not be demonstrated. All tumours were negative for laminin immunoreactivity. The limitations of staining for neurone-specific enolase are discussed and the value of CAM 5.2 in the differential diagnosis of cutaneous neuro-endocrine tumours is emphasized. The histogenetic implications of the absence of laminin staining are considered.

Aged↗
PubMed1985

Metastatic tumours of the nasal tip.

Two cases of metastatic tumour at the nasal tip are described. Both originated from a primary tumour of the bronchus. In each case the lesion was the first sign of an otherwise silent neoplasm.

Aged↗
PubMed1985

Small cell carcinoma of skin: a report of two cases.

We present two cases of small cell carcinoma of skin and review the evidence for the origin of these tumours from Merkel cells situated in the basal layers of the epidermis. The aggressive behaviour of these tumours makes their initial histological diagnosis important if careful follow-up is to be instituted and we suggest that more radical primary treatment might improve results. We emphasise the need to exclude an origin from other sites apart from skin and the role of electron microscopy and immunohistochemistry in identifying these tumours as being distinct from other poorly differentiated carcinomas.

Aged↗
PubMed1984

Cutaneous lymphomas of the face and scalp.

The presentation of malignant lymphoma as a solitary, discrete cutaneous nodule on the face or scalp is rare. This paper describes the clinical features of five patients with this manifestation of lymphoma referred to one plastic surgery unit over a period of 3 years.

Adolescent↗
PubMed1984

Glomerular disease in adults in the Savannah region of Nigeria--clinical and pathological features.

In a consecutive series of 134 adult patients with glomerular disease, 82.7% showed proliferative glomerulonephritis on renal biopsy; 45% of the cases were asymptomatic. Nephrotic syndrome in adults in northern Nigeria should respond to immunosuppressive therapy only rarely. There was no evidence to implicate Plasmodium malariae as the cause of glomerular disease in adults in the savannah belt in Nigeria. The roles of hepatitis B virus and Yersinia enterocolitica were discussed and require further serological investigations. O-serotype 8 yersiniosis is reported outside the USA for the first time and is possibly nephritogenic. Hepatosplenomegalic schistosomiasis is also reported for the first time in Africa south of the Sahara. The role of the eradication of infections due to the Streptococcus, hepatitis B virus, P. malariae, schistosomes and Y. enterocolitica in the reduction of glomerular disease is discussed.

Adolescent↗
PubMed1984

Multiple lymphomatous polyposis of the gastrointestinal tract.

Multiple lymphomatous polyposis (MLP) is a distinctive type of primary gastrointestinal lymphoma characterized by polypoid accumulations of lymphoma tissue involving long segments of the gastrointestinal tract. A study of four cases of MLP has shown a tendency for ileocaecal involvement and extra-abdominal dissemination. The lymphoma is of centrocytic type and exhibits a nodular pattern of variable degree. Trapping of reactive follicle centres with replacement of their mantle zones is characteristic. Immunohistochemical studies show a high concentration of monotypic SIg demonstrable in both cryostat and paraffin sections together with the other features of malignant lymphoma, centrocytic. The histological features of MLP bear a close resemblance to those of intermediate cell and mantle zone lymphoma, as described by American workers, which suggests that these two conditions and malignant lymphoma, centrocytic, are the same entity. In the gastrointestinal tract malignant lymphoma, centrocytic, produces a characteristic classic clinicopathological picture (MLP). In view of its less favourable prognosis it is important to distinguish MLP from other primary gastrointestinal lymphomas of follicle centre cell origin.

Aged↗
PubMed1984

Computerisation of histopathology/cytology records--use of a commercial data storage system.

A system for computerising histopathology/cytology records using a commercial data processing system is described. It is emphasised that any system of computerising records should have some flexibility as no two laboratories have the same requirement and new applications and requirements may arise as one goes along. It is suggested on the basis of the authors' experience over the past two years that it might be worthwhile for histopathologists/cytopathologists interested in computerisation of records to consider the possibility of "user-friendly" software systems, which can be adapted to their particular requirements, rather than a tailor made system, which might be difficult to modify.

Cell Biology↗
PubMed1984

Crohn's disease and pericarditis.

A patient is described who developed acute pericarditis during a severe first attack of Crohn's disease. The opportunity was taken to measure levels of circulating immune complexes, both during the acute phase of the illness and during convalescence; no significant change in these levels from normal values was found. The Crohn's disease and the associated pericarditis responded to systemic corticosteroid therapy, and no relapse has occurred during 14 months of follow-up.

Adult↗
PubMed1982

Desmoplastic malignant melanoma: the first British report.

A case report from Louisville, Kentucky was recently published in this Journal describing a patient with a desmoplastic malignant melanoma of the cheek (Man et al., 1981). Reference was made in that report to 15 previously described cases of this tumour, all from the United States of America. We wish to report a recent patient of ours with a tumour that was histologically consistent with a desmoplastic malignant melanoma but showed several atypical clinical and histological features. This is, as far as we know, the first recorded occurrence of the tumour outside the USA.

Aged↗
PubMed1981

Perianal Paget's disease associated with cloacogenic carcinoma: report of a case.

A case of perianal Paget's disease associated with a cloacogenic carcinoma is presented. There was no clinical evidence of the Paget's disease, which was confined to a very small area. The points of particular interest were (1) the association of Paget's disease with a cloacogenic carcinoma, and (2) the dissimilarity between the pagetoid cells and the carcinoma cells. The histologic differences between the two cell types support the view that perianal Paget's disease and underlying carcinomas represent a multicentric reaction to an unknown stimulus.

Aged↗
PubMed1981

Oral and maxillofacial tumours in Northern Nigeria: an analysis over five years.

A clinical and histopathological review of 200 oral and maxillofacial tumours seen at the Maxillofacial Unit at Kaduna, Nigeria during a five-year period is presented. A large number of these were odontogenic tumours, bone tumours and tumours of the maxillary antrum. Some of the unusual histological features seen are discussed. One feature of particular interest was the large number of osteosarcomas, chondrosarcomas, fibrous dysplasias and ossifying fibromas of the jaw bones, as opposed to the long bones.

Adolescent↗
PubMed1979

Yersinia enterocolitica infection from West Africa--a case report.

A case of Yersina enterocolitica infection is described from West Africa. Intestinal function studies demonstrated an associated protein-losing enteropathy whilst the histo-pathological appearance of the rectum suggested an ischaemic colitis. Y. enterocolitica infection has been infrequently reported from the African continent and may be manifested in a variety of clinical presentations leading to difficulty in diagnosis.

Adult↗
PubMed1979

Epidermodysplasia verruciformis in Nigerians.

An analysis of the clinical and pathologic characteristics of 12 Nigerian patients with epidermodysplasia verruciformis (EV) is presented. Two morphological variants have been observed, typical wart-like flat-topped papules and larger confluent plaques. Seborrhoeic keratoses were observed in patients with the second morphological variety of EV. Solar elastosis was found in biopsies taken from EV lesions in this subgroup of patients. A particular rarity of seborrhoeic keratosis in Africans is emphasized as no single African case of seborrhoeic keratosis was found apart from patients with EV. No malignant epithelial skin tumours were found in the whole group. Factors underlying an apparently more benign course of EV in Africans are discussed, and the literature on EV in African is reviewed.

Adolescent↗
PubMed1979

A case of paracoccidioidal granuloma in norther Nigeria.

A case of Paracoccidioidal granuloma in Northern Nigeria is presented. The fungus could be cultured and identified as Paracoccidioides brasiliensis. Histology revealed a fungal lesion due to a yeast like organism. The patient responded to long acting Sulphormethoxine (Fanasil). A variation from the classic histopathological description and association of pustular psoriasiform lesions on the soles with a possibility of 'Id' reaction to the fungus are discussed.

Adult↗