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Biomedical subjects

S G Sukhanov

Publications and source records attributed to S G Sukhanov.

14 recordsLinked to original sources
PubMed1992

[Various indicators of the hormonal profile in patients with neuroses after psychopharmacotherapy and functional test with sinacten].

Studies of adenohypophyseal hormones, cortisol, T3, T4, thyroxine-binding globulin, testosterone, progesterone and estradiol in 90 neurotic men, treated or not with amitriptyline and benzodiazepines, allowed a conclusion that in the majority of them, endocrine functions were activated. 11 healthy men and 11 male patients underwent the three-day test with sinacten-depot (1 mg intramuscularly). The functional test data were compared over time by the methods of nonparametric statistics. The patients manifested a decrease of reserve potentialities of the pituitary-adrenal system, redistribution of the fractions of thyroid hormones, gonadotropins, the progesterone/estradiol ratio, a rise of prolactin and testosterone secretion. The drugs were found to improve the functioning of the pituitary-adrenal system. However, they did not contribute much to the positive changes in the pituitary-thyroid and other systems.

Adrenal Cortex Hormones↗
PubMed1990

[The age-related pathomorphology of the thyroid in inhabitants of the European North].

Thyroids of 185 males of different ages (from 17 to 75 years) were examined by histological and stereological methods. All persons died accidentally. Cases were not connected with endocrinological diseases. Maximum weight of organ (18.1 +/- 1.2 g) was at the age of 31-40 years. In all cases the thyroids were characterised by the large-follicular type of structure with a moderately pronounced colloid resorption and desquamation of thyrocytes. Statistically significant changes of nuclear volume and volume density of thyrocytes with age were found stereologically. It is concluded that the conditions of the European North influence the speed of the involutionary changes in the thyroid.

Adolescent↗
PubMed1989

[Status of the hypophyseo-adrenal system and functional morphology of the adrenal glands in residents of Northern European areas of the USSR].

Serum corticotropin and cortisol levels were measured in 20-40-year old healthy residents (144 males and 361 females) in the North. A functional Synacthen Depot test was performed in 5 volunteers. The adrenal glands from 56 males and 8 females of the same age who had died from accidents were pathohistologically and stereometrically examined. The signs of functional tension were established in the pituitary-adrenal cortex system. The Synacthen Depot test determined sufficient potentials of the organ to show responses to specific stimulation. Morphologically, a number of changes were found, which might be regarded as a prerequisite to the development of functional and pathological disturbances in the above-mentioned link of the endocrine system.

Adaptation, Physiological↗
PubMed1989

[Clinical value of transesophageal electric stimulation of the heart in patients with occlusive diseases and aneurysms of the aorta and major arteries during preparation for surgery].

A total of 325 patients with occlusions and aneurysms of the aorta and its main branches were investigated preoperatively. The patients were divided into 2 groups; in one of those (32 patients), esophageal electrostimulation of the heart was used for the diagnosis of latent coronary insufficiency. In addition to the degree of myocardial ischemia, the efficiency of antianginal drugs and the results of preoperative medication were assessed here. Comparative analysis of the results demonstrated a higher sensitivity and diagnostic value of esophageal electrostimulation, as compared to routine lead tests, which, in combination with the test's simplicity and noninvasiveness as well as possible identification of diagnostically-meaningful criteria, makes it a method of choice.

Adult↗
PubMed1988

[Hormone content of the blood in neurotic patients].

Radioimmunoassay was applied to study the hormones (corticotropin, cortisol, T3, T4, testosterone, prolactin, follicle-stimulating and luteinizing hormones) in 52 male neurotic patients and 120 healthy donors in Arkhangelsk city, as compared to latitudinal mean values. In patients, prolactin, cortisol, thyroid hormones and gonadotropins were increased by 82.7%, 48.7%, 41%, 52.6%, respectively. Patients also had lower production of ACTH, higher blood contents of T3, prolactin and testosterone. Unidirectional shifts were detected in hormonal systems of neurotic patients, with respect to the time of the disease onset and the duration of last exacerbation: ACTH secretion increased with reduced response of adrenal cortisol production, compensatory increase in thyroid functions, redistribution of gonadotropic fractions increasing the FSH/LH ratio, decrease in testosterone production. At the initial stages prolactin secretion increased to reach later its plateau.

Adult↗
PubMed1988

[Idiopathic Addison's disease].

Two cases of idiopathic Addison's disease affecting heterozygous twins who died from addisonian crisis at the ages of 7 and 10 years, are described, including descriptions of histologic findings in the adrenals, thymus, hypophysis, kidneys, esophagus, upper respiratory tract, and other viscera. The authors believe that autoimmunization in children with idiopathic Addison's disease develops in the presence of congenitally defective immunity and propose that activation of the juxtaglomerular complex and hypergranulation of interstitial cells in the inner renal medulla may be used as morphologic criteria in the diagnosis of addisonian crisis.

Addison Disease↗
PubMed1981

[Mathematical modeling of pathomorphologic changes in the spinal cord during prolonged cooling].

Experiments were made on 72 rabbits exposed to daily 10-12-hour cooling at a temperature of -3-5 degree C for 1, 2, 4, 8 and 12 weeks. Use was made of a complex of morphometric methods to study neuro-capillary, neuroglial, relationships and nucleoprotein metabolism in the cervical, thoracic and lumbosacral parts of the spinal cord. The data obtained were processed on Nairi-K and Minsk-32 computers. All the changes in the parameters examined can be depicted mathematically by the equation Y = A0 + A1X + A2X2. Differences were revealed in the responses of different parts of the spinal cord to cold exposure to attribute the cervical segments to the increased risk area for the development of unfavourable pathomorphological alterations.

Acclimatization↗
PubMedDate not supplied

[Functional and morphologic changes in the heart following phrenicotomy].

Experiments on dogs showed that the phrenic nerves participate in innervation of the heart. Their division in the cervical portion is attended with disorders of the rhythm, abnormalities in the components of the electrocardiogram, and degenerative changes in the intramural nerve apparatus of the heart. The results of the experiments indicate that the use of the phrenic nerve as a donor in a plastic operation of the nerve trunks should be considered an operation of choice.

Animals↗
PubMedDate not supplied

[Adrenal structure in the fetuses of humans living in the European North].

The adrenals of 194 human fetuses of 17-40 weeks and newborn infants were studied by histological and morphometrical methods. The abortive material was taken at hospitals in the city of Arkhangelsk and regions beyond the Polar circle. The mass of adrenals was found to be reliably less as compared with the norms in middle latitudes, and the rate of increase of this index decreased in the dynamics of pregnancy. The microscopic and stereometric investigations have revealed decreased thickness of the cortex, adaptational and pathological changes of adrenocorticocytes. Little mass of the adrenals was associated in some cases with a premature formation of the cortex zones.

Adrenal Glands↗