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Biomedical subjects

S Günther

Publications and source records attributed to S Günther.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Serum carotene and serum retinol in psoriasis].

The serum carotene and retinol levels were determined in 25 male psoriatic patients and 25 healthy male controls. No difference was observed in carotene level, however, retinol level was found lower in psoriatic patients as compared to controls.

Adult↗
PubMed1985

[Sulfides in acne].

Fifty-three patients suffering from acne vulgaris or acne conglobata have been treated with natural sulphides over a period of 4 weeks. All cases showed improvement; normalization of the skin could be achieved in 36 patients (67.9%).

Acne Vulgaris↗
PubMed1984

[Psoriasis vulgaris--sulfur brine therapy in 140 patients].

140 patients suffering from generalized chronic psoriasis were treated with the help of the natural sulphur resources of St. Peter-Ording over a period of 4 to 6 weeks. In 135 of these cases (96.4%), the skin became well improved. In 4 patients (2.9%) the skin lesions remained unchanged, while in only one case (0.7%) the lesions worsened.

Adolescent↗
PubMed1977

[Vitamine A acid therapy in autosomal dominantichtyosis (author's transl)].

In autosomal dominant ichthyosis, a permanent cure is impossible, and symptomatic treatment is most important. At present, known therapeutic procedures have had little or no influence in this disease. Following the application of 0.1% vitamin A acid ointment, especially in children, the skin became free of scales within a few weeks. After improvement, a maintenance dosage of one application per week in most cases was sufficient to avoid any recurrence. Possible side effects of this treatment are mentioned. Sereral possibilities regarding the mode of action of vitamin A acid are discussed.

Administration, Topical↗
PubMed1976

[Systemic side effects of external corticoids: results of dermatologic studies in children with neurodermititis].

Of 111 children with atopic dermatitis who were admitted as in-patients in a German aero-biological childrens clinic, 83 patients (74.8%) had been prescribed a prolonged corticosteroid therapy from their family doctor. For 60 children (54.1%) the corticosteroid application was topital, partly with occlusive dressing or with fluorinated preparations. The remaining 23 children (20.7%) were treated topically and systemically with corticosteroids. Of the 60 children whose atopic dermatitis was treated exclusively with topical corticosteroids, 59 patients (98.3%) showed undesirable side effects. Moreover, irreversible body changes developed through the transcutaneous absorptive processes, which were more evident and appeared more often in girls than in boys.

Administration, Topical↗
PubMed1976

[Incidence and degree of unwanted adverse effects of corticoids in childhood: results of dermatological studies in children with chronic diseases in the age group of 1-15 years].

Out of 416 children suffering from atopic diseases 288 (69.2%) were treated topically, systemically or topically and systemically with corticosteroid preparations by the general practitioners. In 236 (81.9%) of these cases, children between the age of 1 and 15 years, developed undesirable, in part irreversible side effects. In some of the cases, topical corticosteroids by skin absorption also caused systemic side effects. It is therefore questionable if the application of corticosteroids during childhood in atopic diseases is really a therapeutic advance.

Acne Vulgaris↗
PubMed1976

[Corticosteroid therapy in atopic diseases of children? (author's transl)].

Of 416 children suffering from different atopic diseases who were admitted as in-patients in a German aero-biological childrens clinic, 69.2% had previously received corticosteroid therapy. According to dermatological findings, 81.9% of these patients developed undesirable side effects. Of the children whose atopic dermatitis was treated prolonged with topical corticosteroids, also irreversible body changes developed through the transcutaneous absorptive processes, which were more evident and appeared more often in girls than in boys.

Adolescent↗
PubMed1975

[Herpes zoster as cause of an epidemic spread of varicella and zoster in a children's hospital].

During infancy zoster is not so rare as generally stated. In this age group the infection seems often to be unrecognised, because commonly it produces little or atypical body reactions. In children the infectivity of zoster is more serious than in adults, but in the absence of antibodies, varicella develops. Therefore zoster has been considered as an immunologically modified form of varicella. In my own experience, one case of zoster caused epidemics of varicella and zoster in a paediatric hospital. The pathogenesis and epidemiology of the two diseases have been discussed.

Antibody Formation↗
PubMed1975

[Therapeutic effect of vitamin A acid (retinoic acid) in various forms of palmar/plantar hyperkeratoses: experimental studies on 68 patients].

Up to date, the treatment of palmar/plantar hyperkeratoses presents a therapeutic problem. The known therapeutic procedures result in short-term improvement only, if any at all. In these investigations involving 68 patients suffering from palmar/plantar hyperkeratoses of different etiology, small doses of vitamin A acid (retinoic acid) topically applied, produced a striking improvement in hypertrophic lichen planus of palms or soles: the regression was complete and in most cases permanent. The skin texture of patients with genetic keratoses and callosities became normal within a few weeks: but this condition remained free of symptoms only as long as vitamin A acid was used as a maintenance dose once or twice weekly. In hyperkeratotic exzema, pityriasis rubra pilaris, and in verrucae plantaris vitamin A acid topically applied was found to be unsuitable for treatment. The possible side effects of this treatment are mentioned. Several possibilities regarding the way of action of vitamin A acid are discussed.

Administration, Topical↗
PubMed1975

[Kyrle's disease (hyperketarosis follicularis et parafollicularis): local and systemic therapy with vitamin A acid (retinoic acid)].

The cause of Kyrle's disease (hyperkeratosis follicularis et parafollicularis) is unknown. The prognosis is very poor indeed; there is no specific treatment. The normal ranges of serum retinol and carotene were investigated in 10 healthy females. In a female patient suffering from Kyrle's disease, the serum level of retinol was found in the lower part of the normal range. Striking improvement has been noted when the patient was treated systemically with vitamin A acid (retinoic acid) which was associated with elevation of serum levels of retinol and carotene. When this form of therapy was withdrawn, recurrence of the skin lesions was observed and the serum levels of retinol and carotene declined to a level similar to that before the treatment. The administration of vitamin A acid was resumed, and with rising levels of retinol and carotene the skin condition again improved. Several possibilities regarding the treatment of Kyrle's disease as well as the mode of action of vitamin A acid are discussed.

Aged↗
PubMed1975

[The mechanism of action of vitamin A acid].

Although vitamin A acid has been used successfully in medicine for several years, the mode of action is still unknown. Clinical investigations have shown, that the application of vitamin A acid is associated with elevation of serum levels of vitamin A and after high dosage side effects develop similar to hypervitaminosis A. Several possibilities regarding the mode of action of vitamin A acid are discussed; it seems to be most likely: 1. The vitamin A depots of the body are mobilized by vitamin A acid. 2. The release of lysosomal enzymes is dependent on the serum level of vitamin A. 3. The unlimited DNS and RNS syntheses are inhibited by the action of lysosomal enzymes. 4. Disturbances in this control mechanism cause anomalies in the process of keratinization and the cellular turnover of epithelial tissues.

Epithelium↗
PubMed1975

[Lichen ruber planus and lichen ruber verrucosus of the skin: therapeutic results using vitamin A acid in 98 patients].

98 patients, 50 suffering from papular lichen planus of the skin, 48 suffering from hypertrophic lichen planus, were treated systemically or topically with vitamin A acid. In 52 out of the 98 patients, the treatment was started within the first 3 months after the beginning of the disease. The patients with papular lichen planus improved rapidly to systemic vitamin A acid administration. In hypertrophic lichen planus only topical vitamin A acid application showed satisfactory results. The possible side effects of this treatment are mentioned. Patients with disturbed hepatocellular of hepatocystic conditions are unsuitable for vitamin A acid therapy.

Administration, Oral↗
PubMed1975

[Effectiveness of vitamin A acid in diseases of the mouth mucosa: lichen ruber planus, leukoplakias and geographic tongue].

52 patients, with different pattern of oral lichen planus, pre-malignant leukoplakia or geographic tongue, were treated with vitamin A acid. The systemic medication resulted in regression of discrete papules and leukoplakia-like appearance of oral lichen planus. Linear-hypertrophic pattern of the oral mucosa showed distinct involution only by topical administration of vitamin A acid. Also the patients suffering from pre-malignant leukoplakia or geographic tongue partly improved after a vitamin A acid therapy. Systemic side effects were noted after ignoring the tolerance limit (30 mg/day vitamin A acid/3 weeks). Inflammation and occasionally maceration appeared when local treatment was used over 3 weeks. Recurrence was observed in 11 patients.

Administration, Oral↗
PubMed1975

[Local vitamin A acid therapy in palmar/plantar hyperkeratoses (authors transl)].

Up to date, the treatment of palmar/plantar hyperkeratoses presents a therapeutic problem. The known therapeutic procedures result in short-term improvement only, if any at all. In these investigations involving 68 patients suffering from palmar/plantar hyperkeratoses of different etiology, small doses of vitamin A acid locally applied, produced a striking improvement in hypertrophic lichen planus of palms or soles: the regression was complete and in most cases permanent. The skin texture of patients with genetic keratoses and callosities became normal within a few weeks: but this condition remained free of symptoms only as long as vitamin A acid was used as a maintenance dose once or twice weekly. In hyperkeratotic eczema, pityriasis rubra pilaris, and verrucae plantaris vitamin A acid locally applied was found to be unsuitable for treatment. The possible side effects of this treatment are mentioned. Several possibilities regarding the way of action of vitamin A acid are discussed.

Callosities↗