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S Gaebler

Publications and source records attributed to S Gaebler.

5 recordsLinked to original sources
PubMed1993

Predicting which patient will fall again ... and again.

In order to compare the characteristics, preventive interventions and outcomes of single and multiple fallers, a retrospective cross-sectional study was conducted in a 680-bed acute-care hospital in Western Australia. Fifty patients falling more than once (multiple fallers) were randomly selected from all patients reported to have fallen between 1 July 1989 and 31 December 1989, and age-sex matched with 50 patients falling once in the trial period (single fallers). In total, 382 in-patients were reported to have sustained 578 falls in the 6-month trial period. Fifty-two per cent of these falls involved multiple fallers. An analysis of the 100 single and multiple fallers showed that single fallers were more likely to have fallen from their bed; be discharged home from hospital; and be clinically deteriorating at the time of the fall. Multiple fallers were more likely to be transferred to a long-term nursing facility after discharge from hospital; suffer blindness/poor vision; be sedated post fall; be ordered to be restrained following a fall; and be hospitalized for longer periods. There was also a tendency for multiple fallers to repeat the type and location of the fall on successive falls. Stepwise logistic regression showed that falling from the bed on the first fall predicted remaining a single faller. Being ordered to be restrained following the first fall and hospitalized for longer periods predicted the patient would fall repeatedly. Further analytical research incorporating an expanded number of independent variables is needed to allow confident assertions of causality. To test the effectiveness of preventive measures, a prospective longitudinal study is required.

Accidental Falls↗
PubMed1989

Quantification and kinetics of purine catabolism in Dalmatian dogs at low and high purine intakes.

1. In eight Dalmatian dogs low and high purine intakes resulted in plasma urate levels from 25 to 185 mumol/l. 2. The relationship between purine intake and excretion of uric acid and allantoin per day was described by linear regression equations. 3. The elimination of endogenous purines was 1.8 mmol/day for urate and 1.7 mmol/day for allantoin. Exogenous purines increased renal excretion by 0.57 mmol/mmol. 4. Kinetic measurements with [2(-14)C]uric acid infused continuously into each of two dogs on low and high purine revealed increases of plasma pool (urate + allantoin) of 3.3 fold and entry rate of 4.0 fold. Conversion of urate into allantoin increased from 20 to 36%. 5. Renal elimination of catabolites increased 3.3 fold and exhalation rate of purine-CO2 379 fold. Extra-renal elimination at high purine intake was quantitatively similar to humans and closely related to pool size.

Allantoin↗
PubMed1982

Purine availability and metabolism in dogs fed single-cell protein or RNA.

For the evaluation of single-cell protein (SCP) the proportion of dietary purines made available by digestion and absorption was estimated with dogs (Dalmatian) in total urine collection experiments. The animals received a low purine control diet with 25% casein, diets with 25-100% replacement of casein by a bacterial SCP grown on methanol, and the control diet plus yeast RNA purine equivalent to SCP diet. Nucleic acids, bases, and purine metabolites were determined by reversed-phase high-pressure liquid chromatography. The quantitative influence of dietary purines (x) on renal purine excretion (y) was described by the equation (millimoles per day) y = 0.57x + 3.52 (r = 0.955) indicating the endogenous excretion rate of 3.5 mmol/day and the metabolic availability of 57% of ingested purines. As the ratio of urate to allantoin increased with purine intake, individual equations were established for both metabolites. On the control diet + RNA and SCP diet (100% replacement for casein), purine intakes of 20.0 and 18.2 mmol/day resulted in purine excretion values of 7.3 and 11.4 mmol/day (P less than 0.05). The proportion of free bases in the latter diet appeared as the main reason for this differences. Other influences are discussed.

Allantoin↗