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Biomedical subjects

S Galindo

Publications and source records attributed to S Galindo.

9 recordsLinked to original sources
PubMed1998

Anaesthetic implications of Cornelia de Lange syndrome.

Cornelia de Lange syndrome is a congenital disease characterized basically by psychomotor retardation associated with a series of malformations (mainly skeletal craniofacial deformities together with gastrointestinal and cardiac malformations). We present the case of a patient who underwent trauma surgery, discuss the anaesthetic problems involved and their relationship to the malformations that constitute this syndrome.

Abnormalities, Multiple↗
PubMed1997

Anterior cervical myelopathy in the early postoperative period.

PURPOSE: The onset of anterior cervical myelopathy in the early postoperative period is an unusual complication after cardiac surgery without extracorporeal circulation in which haemodynamic stability was maintained. We report a patient who developed anterior cervical myelopathy after cardiac surgery. CLINICAL FEATURES: A 53-yr-old man with no serious associated medical problems underwent cardiac surgery without extracorporeal circulation to repair a ruptured left ventricle. Haemodynamic stability was maintained throughout the procedure but the patient developed flaccid paraparesis and dissociated sensory loss, three hours later. Early recognition of the clinical picture and prompt initiation of steroid treatment facilitated a successful outcome. The definitive diagnosis was based on magnetic resonance findings days after surgery. CONCLUSION: The onset or aggravation of neurological symptoms in the postoperative period may be avoided by thorough search for medullary pathology in the patient's background and by using particular care when performing manoeuvres during the perioperative period, not only to ensure haemodynamic stability, thus preserving medullary perfusion, but also to avoid mechanical compression of a spinal segment.

Cardiac Surgical Procedures↗
PubMed1997

[Postoperative cognitive dysfunction].

Although postoperative behavioral anomalies were first reported more than one hundred years ago, only in the past ten years has the profile for postoperative cognitive dysfunction (POCD) been defined. POCD is reversible and it has been suggested that the disorder has implications for increased mortality and morbidity if it is not diagnosed and treated early. At present the clinical presentation of POCD is thought to be variable and fluctuating, ranging from slight disorientation to coma. POCD can develop soon after surgery or appear several days later and its incidence is unknown as a result of the methodological difficulties involved in studying this entity. Of the various etiological factors that have been named, many can be modified during the period surrounding surgery. Once symptoms have developed,whether in the recovery unit or later, it is important to eliminate organic factors and begin treating the cause. The most important drugs for treatment are neuroleptics and benzodiazepines. We review the definition, epidemiology, etiology, pathophysiology and treatment of POCD and include a list of diseases and drugs associated with its development, as well as a description of psychological tests used for diagnosis.

Cognition Disorders↗
PubMed1997

Pseudoaneurysm of the femoral artery following percutaneous puncture and cannulation for invasive monitoring.

The risk of damage to the femoral artery after its cannulation is low; it coincides with a series of risk factors that include the use of relatively large-diameter introductor sheaths. We present a case in which pseudoaneurysm of the femoral artery developed after the introduction of a 16-gauge catheter (Abbocath, Abbott Laboratories, Chicago, Illinois, USA) into this vessel for the invasive monitoring of the arterial pressure in a patient who was admitted to the Postsurgical Intensive Care Unit during the postoperative course because of hemodynamic instability secondary to septic shock. We also discuss the prophylactic and therapeutic measures that can prevent or alleviate, respectively, that complication.

Aged↗
PubMed1995

Rat brain glucose and energy metabolites: effect of +Gz (head-to-foot inertial load) exposure in a small animal centrifuge.

A unique small animal centrifuge with on-line physiological monitoring and brain tissue collection (in < 1 s) capability was used to investigate the effect of increasing +Gz levels, exposure duration, number of exposures, and time course of metabolic changes in the rat brain. To determine the +Gz tolerance, rats were exposed to +7.5 to 25 Gz (30 s each) and EEG was monitored. G-induced loss of consciousness (G-LOC) defined as isoelectric EEG (I-EEG) occurred only at +22.5 and 25 Gz within 14.5 +/- 3 s. To study the effect of increasing +Gz levels on metabolism, rats were exposed to either 0.5 (control) or +7.5 to 25 Gz (30 s each), and brains were collected 1 min postcentrifugation by freeze fixation. A significant increase in lactate (> or = +7.5 Gz) and a decrease in glucose, creatine phosphate (Cr-P), and ATP levels were observed at +15 Gz and higher. The effect of exposure duration was investigated by exposing the rats to +22.5 Gz for 15-60 s. Brain lactate levels increased six-fold while glucose decreased (75%) following the 60-s exposure. The level of Cr-P and ATP decreased significantly after the 15- and 30-s exposures with no further changes at longer +Gz exposures. For time course studies, brains were collected both during (5-35 s) and after (1-15 min) a +25 Gz exposure. A significant decrease in Cr-P occurred within 5 s, but changes in glucose, ATP, and lactate required 15 s. All metabolites returned to control levels within 3 min, except lactate and adenosine, which required 15 min.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

EPR signal enhancement of alanine irradiated with thermal neutrons.

A method to enhance the electron paramagnetic resonance signal amplitude response of alanine to thermal neutrons is presented. The method is based on the production of additional free radicals caused by alpha-particle and 7Li interactions on the alanine. These particles emerge from the neutron capture 10(5)B (n, alpha) 7(3)Li reaction. For this purpose, alanine and boric acid are intimately mixed. Mixture intimacy is critical for optimum enhancement. A way to achieve good mixture intimacy is suggested. A signal enhancement up to 2200% is obtained.

Alanine↗
PubMed1991

Use of alanine-silicone pellets for electron paramagnetic resonance gamma dosimetry.

Silicone is proposed as an alternative binding substance in the production of D-L alanine pellets used in electron paramagnetic resonance (EPR) dosimetry of gamma rays. The dosimeters are manufactured at room temperature, making the production simple. Examination by EPR silicone-alanine pellets irradiated with 60Co gamma rays in the dose range 10 to 10(6) Gy shows that the proposed silicone binder does not affect typical alanine dose-response curves. Thermal stability of the pellets below 40 degrees C is good, but their pre-dose EPR signal amplitude is slightly higher than for nonirradiated alanine.

Alanine↗
PubMed1980

The paucity of breast-feeding in an urban clinic population.

The lack of breast-feeding among mother-infant dyads utilizing public sector clinics in Los Angeles is presented in this brief study. Whereas the middle and educated classes have begun a resurgence of breast-feeding, this renaissance is missing among the poor. Awareness, health education (by peer advocates), early intervention and reassurance by all levels of health providers is suggested to prevent the dissolution of the lactation bond among the population least apt to breast-feed.

Age Factors↗