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Biomedical subjects

S Gargano

Publications and source records attributed to S Gargano.

25 records · Page 2Linked to original sources
PubMed1984

Antibiotic prophylaxis in high-risk biliary operations: multicenter trial of single preoperative ceftriaxone versus multidose cefazolin.

A prospective, double-blind trial of a single preoperative dose of ceftriaxone, a new long-acting cephalosporin, versus one preoperative and three postoperative doses of cefazolin was carried out in 81 patients at high risk of infection after biliary surgery. Indications for antibiotic prophylaxis included recent or ongoing cholecystitis (52 patients), common duct stones (14 patients), common duct obstruction (3 patients), and age greater than 70 years (22 patients). Intraoperative bile cultures were positive in 7 of 41 patients (17.1 percent) given ceftriaxone and 12 of 40 patients (30 percent) given cefazolin, but there were no wound infections in either group. Neither regimen was associated with significant antibiotic resistance. Side effects, such as proteinuria and elevated liver transaminases and alkaline phosphatase levels, were transient and not definitely related to the antibiotics. We conclude that a single preoperative dose of ceftriaxone is as effective as multiple perioperative doses of cefazolin in the prophylaxis of infection associated with biliary tract surgery.

Adolescent↗
PubMed1976

Increase of rDNA redundancy in bb females of Drosophila melanogaster.

The purpose of this work was to analyze the difference between males and females with respect to rDNA magnification. To study eventual rDNA variations in females aYbb chromosome was chosen since it can magnify in males but not show phenomena of rDNA dosage compensation. The authors have observed an increase of rDNA pertaining to the Ybb chromosome in females of XXNO-/Ybb genotype with respect to the same Ybb chromosome studied in XXbb+/Ybb females. This non-inheritable rDNA increase cannot be explained in terms of compensatory increase reported in X/O males nor can it fit in the magnification scheme. The possibility might be entertained that some mechanism is missing in females which cannot complete a magnification cycle. The rDNA increase that we called rDNA magnification in males occurs in the germ line and in the soma, whereas the evidence, here reported, suggest that magnification in females occurs only in the soma.

Aneuploidy↗
PubMed1976

[Incidence of hepatic metastases of breast cancer. Scintigraphic study with radiocolloids in 111 patients].

The anatomical and physiological premises of liver scintigraphy with radiocolloids as a useful study in patients suffering from various stages of breast cancer are analysed. A series of 111 cases is then reported. The technique was used on these cases one or more times and revealed the presence of a scintigraphic picture suggesting liver metastasis in 36% of cases (27.5% at first observation). These data proved higher than those previously reported in the literature by other workers. The technique is therefore proposed as a routine investigation in patients suffering from breast cancer.

Adult↗
PubMedDate not supplied

CAMP is involved in transcriptional regulation of delta9-desaturase during Histoplasma capsulatum morphogenesis.

We have characterized the promoter region of the delta9-desaturase gene from two different strains of the dimorphic fungus Histoplasma capsulatum. Desaturase transcription is regulated in the two phases of growth: it is transcribed in the yeast phase at 37 degrees C, while it is inactive in the mycelial phase at 25 degrees C. Phase transition can be induced by shifting the temperature from 25 to 37 degrees C or by adding cAMP to the growth medium. We have identified a stress-responsive cis element (STRE) responsive to cyclic AMP (cAMP)-signaling pathway and demonstrated that this element acts in H. capsulatum. We have also identified an element, hereafter called DRE (Desaturase Regulatory Element), present in the promoters of the H. capsulatum and S. cerevisiae delta9-desaturase gene. We show that this element is necessary but not sufficient to regulate transcription of the H. capsulatum delta9-desaturase gene.

Base Sequence↗