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Biomedical subjects

S Garrett

Publications and source records attributed to S Garrett.

103 records · Page 6Linked to original sources
PubMed1982

Histologic probe position in treated and untreated human periodontal tissues.

This study was designed to histologically determine the relationship of the periodontal probe tip to the periodontal tissues during probing of untreated periodontal pockets and periodontal pockets treated with oral hygiene and root planing. Human, condemned, single rooted teeth with buccal probing pocket depth at least 6 mm were used. Two groups of specimens were included: 12 untreated teeth from six patients and 15 treated teeth from 10 patients. In the treated group, the effects of therapy were monitored clinically every 2 weeks until maximum improvement had taken place. A periodontal probe tip was then inserted on the buccal aspect of the tooth using 0.50 N pressure, and block section biopsies were taken. The histologic examination of the untreated teeth showed that the probe tip penetrated beyond the apical termination of the junctional epithelium and into the subjacent connective tissue by a mean of 0.45 +/- 0.34 mm, whereas in the treated specimens the probe stopped coronally to this landmark by a mean of 0.73 +/- 0.80 mm. This study demonstrated that the probe tip most often does not reach the base of the junctional epithelium in pockets treated by plaque control and root planing, and that clinical measurements of attachment levels are not reliable in determining the true histologic level of connective tissue attachment.

Dental Instruments↗
PubMed1981

Transfer of RP4::Mu to Salmonella typhimurium.

Restriction-proficient strains of Salmonella typhimurium are shown to be ineffective as recipients of normal RP4::Mucts62 due to the operation of two restriction systems (hsdSA and hsdLT) on the Mu moiety of this plasmid. Strains mutant in both these hsd loci are excellent recipients.

Bacteriophages↗
PubMedDate not supplied

Effects of a multimodal pain rehabilitation program: a pilot study.

The purpose of this pilot study was to examine the effects of a multimodal pain rehabilitation program on pain perceptions, opioid usage, activity, down time, sleep, and role function status of 23 chronic pain patients. Data were collected at the start of the program, at the program's completion, and again during a follow-up period (3-11 months afterwards). At the end of the program, patients reported a significant reduction in pain levels, opioid usage, and hours of disturbed sleep. During the follow-up period, patients continued to report significant improvements in activity and role functions as well as significant reductions in opioid usage, sleep disturbance, and down time. These findings provided encouraging preliminary evidence that multimodal pain rehabilitation programs for chronic pain patients may be effective in pain management and functional restoration.

Activities of Daily Living↗
PubMedDate not supplied

Field gleaning as a tool for addressing food security at the local level: case study.

Field gleaning, or harvesting crops after the commercial harvest, has been promoted as a way to increase food security; however, the effectiveness of gleaning programs is not well documented. The purpose of this research was to explore the impact of gleaning on individual gleaners and the community by documenting total amounts gleaned, individual uses of produce, and self-reported benefits and barriers to gleaning. During the 1997 season, approximately 50 gleaners participated in the Pierce County Expanded Food and Nutrition Education Program Gleaning Project; 29 participated in an intensive 4-week study to track use of produce by gleaners. Onsite weighing of gleaned produce revealed that of the 110,000 pounds gleaned by these 50 gleaners from Pierce County farms and orchards during 1997, 85,000 pounds (77%) were donated to local emergency food programs; 25,000 pounds (23%) were taken home by gleaners. Of the produce taken home by the 29 study participants, an estimated 9% was used fresh, 48% was preserved for later user, and 43% was shared with others. During a combination of telephone and in-person interviews, gleaners reported using more fresh produce and sharing knowledge about gardening and food preservation. The most important benefits of gleaning were "stretching my food budget" and "helping provide food for the community." Detailed exploration of the impact of gleaned produce on dietary patterns and use of validated food security measures is warranted considering the volume of produce used fresh, preserved for later use, and given away by gleaning participants.

Adolescent↗
PubMedDate not supplied

Evaluation of bone-implant integration: efficiency and precision of 3 methods.

Computer-assisted planimetry, computer-assisted lineal analysis, and point-counting stereology have been compared with respect to their reproducibility and the time required to analyze bone-implant integration. Sections of 6 threaded dental implants selected from a bone augmentation experiment for their wide range of new bone formation were analyzed by each method 3 times. The bone density and percentage of osseous integration were evaluated at 4 sites around each implant section. It was found that computer-assisted planimetry demonstrated a modest but significantly greater variance (P < .05) in bone density estimates when compared to the computer-assisted lineal analysis and point-counting methods. Computer-assisted planimetry requires a different method of measuring each parameter and separate fields of view to evaluate fields distant from the implant. However, this can all be accomplished with line probes, as in computer-assisted lineal analysis, which extend from the implant surface into the surrounding alveolar bone. Whereas computer-assisted planimetry requires a separate identification of the perimeter of each field to be analyzed (next to and distant from the implant), computer-assisted lineal analysis allows expansion of the field to be evaluated without creating a new field of view. Also, following a limited learning curve, both point-counting and computer-assisted lineal analysis required less time to complete than did computer-assisted planimetry.

Alveolar Process↗
PubMedDate not supplied

Phase I and preliminary phase II observations of high-dose intermittent 6-thioguanine.

6-Thioguanine was administered iv or orally to 66 patients on an intermittent schedule, one dose every 3 weeks. Doses were gradually escalated until moderate toxicity was observed. The dose-limiting toxic effects were myelosuppression and azotemia. The recommended starting doses for phase II or III studies were 700 mg/m2 iv and 1400 mg/m2 orally. Nephrotoxicity and myelosuppression were reversible in all clearly drug-related instances. Myelosuppression was transient, with nadir blood cell counts observed 10-14 days after drug administration. No cumulative toxicity was observed. Antitumor responses were observed in five of 21 evaluable patients with metastatic colorectal carcinoma including two of four previously untreated patients with that disease. Other than a transient response in a patient with endometrial carcinoma, who received her drug orally, all other responses were observed in patients treated iv with 6-thioguanine. Further phase II trials, particularly in colorectal carcinoma, are recommended.

Dose-Response Relationship, Drug↗