Biomedical subjects

S Gasner

Publications and source records attributed to S Gasner.

3 recordsLinked to original sources

PubMed1989

Tangential-radial traction suturing technique for intrascleral foreign material implantation.

We used an intrascleral implantation technique to anchor a keratoprosthesis in the limbal sclera of 22 rabbits' eyes. The tangential-radial traction used in this procedure enabled multivectorial traction forces to be applied while maintaining a tight junction between the biological tissue and the foreign material. During 29 weeks of follow-up there was no postoperative leakage, no cataracts developed, and the anterior chamber was maintained in all the eyes at all times. No ocular infection developed in any eye during the first postoperative month. The compound-force traction used in this procedure may prove useful in other areas of ocular surgery.

Animals↗

PubMed1988

Experimental sclera-implanted keratoprosthesis.

An experimental design of keratoprosthesis anchored into the limbal sclera is presented. The surgical procedure enables a watertight junction between the keratoprosthesis and the globe. Dehiscence of the keratoprosthesis-limbal sclera junction occurs when an area of locus resistentia minoris is created in the lower limbus. An artificial drainage system is necessary for the durability of such a keratoprosthesis.

Animals↗

PubMed1976

Chloramphenicol induced inhibition of platelet protein synthesis: in vitro and in vivo studies.

Chloramphenicol (CAP), an antibiotic which causes various blood dyscrasias, was shown to inhibit in vitro protein synthesis of human blood platelets. The effect is dose- and time-dependent, it is reversible after incubation for 2 h, and is comparable with the suppression achieved by cycloheximide (CXM). Electron microscopic examination revealed swelling and destruction of mitochondria. Administration of CAP to dogs produced a progressive inhibition of platelet protein synthesis as shown by a reduction in the rate of [3H]leucine incorporation into protein. The maximal inhibitory effect of the antibiotic was reached 0.5-4.0 h after its administration, when minimal leucine incorporation values of 9-40% of the control were measured. The suppressive effect of CAP was followed by an overshoot in the incorporation of [3H]leucine, up to a maximum of 602% of the value at zero time of the experiment.

Animals↗