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Biomedical subjects

S Gaughan

Publications and source records attributed to S Gaughan.

6 recordsLinked to original sources
PubMed1992

Operative lung constant positive airway pressure with the Univent bronchial blocker tube.

Constant positive airway pressure (CPAP) to the operative lung during one-lung ventilation (1-LV) with a double-lumen tube increases PaO2; there have been no reports of application of CPAP to the operative lung during 1-LV with the Univent bronchial blocker (BB) tube. This study determined the method of administration and the effect on PaO2 of 10 cm H2O of CPAP to the operative lung during 1-LV (1-LV + 10 CPAP) produced by the Univent BB system. We designed our CPAP system for the Univent BB using an in vitro lung model so that low O2 flow rates (2-4 L/min) yielded clinically relevant levels of CPAP (5-20 cm H2O) over a wide range of lung compliance. The CPAP system simply consisted of placing a resistance to a variable oxygen flow distal to the operative lung. Seven consenting patients who required thoracotomy and 1-LV were anesthetized and their tracheas were intubated with the Univent BB tube; the BB was inserted into the appropriate mainstem bronchus until the proximal surface of the BB cuff was just distal to the tracheal carina. PaO2 was measured in the seven patients during 12 sequences of two-lung ventilation (2-LV), one-lung ventilation (1-LV), and 1-LV with 10 cm H2O CPAP (1-LV + 10 CPAP). 1-LV + 10 CPAP was always instituted on the deflation phase of a previous single tidal inhalation. We found in our patients with a lung compliance of 32 +/- 4 mL/cm H2O that 2.4 +/- 0.2 L/min of oxygen flow produced 1-LV + 10 CPAP.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

Aldehyde oxidases of Drosophila: contributions of several enzymes to observed activity patterns.

At least four enzymes contribute to histochemically, electrophoretically, or spectrophotometrically detectable aldehyde oxidase (AO) activity in Drosophila melanogaster. The one we designate AO-1 contributes the majority of activity measured in extracts of whole flies. Pyridoxal oxidase (PO) is also a broad range AO. It is prominent only in midgut and Malpighian tubules, where it apparently accounts for a substantial fraction of total AO activity. The tissue distributions of these enzymes are clearly disparate despite close linkage of their structural loci and parallel dependence on the mal, lxd, and cin loci. A similarly related enzyme, xanthine dehydrogenase (XDH), is detected as an AO only in electrophoretic gels. A fourth broad range AO, not dependent on mal, lxd, and cin, is confined to the ejaculatory bulb. A similar array of AO isozymes is present in phylogenetically distant Drosophila species.

Aldehyde Oxidase↗
PubMedDate not supplied

It is not necessary to remove a jet stylet to determine tracheal tube location.

A jet stylet is a small internal diameter (ID), semirigid hollow catheter that is inserted into an in situ tracheal tube prior to extubation of a patient who may be difficult to reintubate. After the tracheal tube is withdrawn over the jet stylet, the hollow catheter can be used for jet ventilation or as an intratracheal stylet for reintubation with a new tracheal tube. It was previously thought that after the new tracheal tube was inserted over the jet stylet, the stylet would have to be removed to allow connection of the new tube to the breathing circuit and confirmation of intratracheal placement of the tube. We describe a method for preserving the intratracheal location of the jet stylet while confirming intratracheal placement of the new tracheal tube.

Anesthesia, Inhalation↗