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Biomedical subjects

S Gerson

Publications and source records attributed to S Gerson.

At least 19 recordsLinked to original sources
PubMed1994

Neutrophilic eccrine hidradenitis simulating orbital cellulitis.

Orbital swelling in patients with cancer can reflect neoplastic or infectious processes. Accurate diagnosis can be especially difficult in the face of associated fever and neutropenia. We treated a 30-year-old man undergoing induction chemotherapy for acute myelogenous leukemia, who had fever of unknown origin and periorbital swelling suggestive of orbital cellulitis. However, the periorbital findings were more compatible with passive swelling and hemorrhage. A skin biopsy specimen demonstrated isolated neutrophilic inflammation and necrosis of the eccrine glands. Cultures of the tissue for bacteria and fungi were negative. Pertinent literature regarding eccrine-gland inflammatory disease was reviewed. This unusual entity, termed neutrophilic eccrine hidradenitis, is most common in patients undergoing induction chemotherapy. Cases with infectious causes and cases in neutropenic patients have also been reported. No other patients, to our knowledge, with periocular involvement by neutrophilic eccrine hidradenitis have been described. Neutrophilic eccrine hidradenitis should be added to the differential diagnosis of cases of periocular hemorrhage and swelling in patients with cancer who receive chemotherapy.

Adult↗
PubMed1991

Sequence of changes in rat buccal mucosa induced by zinc deficiency.

In weanling rats, after receiving a zinc-deficient diet (less than 1 ppm) for 4 wk, the buccal mucosa appears hyperplastic. This study determines changes at earlier stages of the lesion. After 9 days of deficiency, the keratin layer had partially converted to parakeratosis and thickened, and the size of the capillary bed was increased. After 18 days, the keratin layer was fully parakeratotic and thickened further. The cellular layer was thickened. The mitotic rate was doubled and rete ridges were convoluted. After 27 days, the keratin and cellular layers were further thickened, and the mitotic rate remained elevated. The rete ridges were further convoluted. The number of mast cells was doubled and the size of the vascular bed had increased further. These findings suggest early and late interactions between the epithelium and lamina propria. After four days on a control diet following 27 days of zinc deficiency, the mucosa returned normal.

Animals↗
PubMed1984

Managing the care of the difficult patient in the emergency unit.

An approach to managing the care of "difficult" patients in emergency units is presented in both theoretical and practical terms. Understanding the conflicts these patients create and how these are exacerbated in an emergency unit setting can often lead to straightforward plans for management. These plans should emphasize consistency as a way of both setting limits and reassuring patients and should set reasonable expectations for health care providers working with these patients. Clinical examples are given to illustrate the use of these principles.

Adult↗
PubMed1980

Chronic granulomatous otitis media in bottle-fed Inuit children.

Otitis media in Inuit children is a problem of relatively recent origin and unknown cause. The prevalence of otitis media in 238 Inuit and 47 Caucasian children in Nain, a small community in Labrador, was determined by examination, and the history of breast-feeding or bottle-feeding was obtained. The prevalence of otitis media was found to be inversely related to the age at which bottle-feeding was started. Clinical observations suggest that otitis media in Inuit children is part of a process leading to chronic foreign body granuloma of the middle ear, and that the granuloma is formed from milk introduced into the relatively short and straight eustachian tubes of Inuit infants by the high negative intraoral pressure necessary for bottle-feeding.

Adolescent↗
PubMed1980

Cell renewal in noncornified and cornified buccal epithelium in the rabbit.

This study was undertaken to compare some aspects of cell renewal in the noncornified and cornified epithelia that are juxtaposed in the buccal mucosa of the rabbit. Specimens were analyzed by autoradiography and scintillation counting at various times after the injection of tritiated thymidine or triated proline. In the noncornified epithelium, the labeling index in the proliferative compartment at 1 hr was 15.5%; in the entire cell population, it was 5.8% at 1 hr, 10.4% at 24 hr, and 20.2% at 72 hr. The leading edge of labeled cells reached the surface by 96 hr. In the cornified epithelium, the labeling index in the proliferative compartment was 8.7% at 1 hr; in the entire nucleated cell population, it was 4.2% at 1 hr, 9.2% at 24 hr, and 12.1% at 96 hr. The leading edge of labeled cells reached the stratum corneum by 96 hr and the surface by 144 hr. It was concluded that renewal occurs at a more rapid rate in the noncornified than in the cornified epithelium under study.

Animals↗
PubMed1980

Psychiatric emergencies: an overview.

The psychiatric emergency ward has become a primary entry point into the network of mental health services for people who need help to cope with their problems of living. It is also the only source of treatment for many chronically mentally ill patients living in the community. The authors critically review the literature on emergency psychiatric services, focusing on the ways these services are used, the atmosphere in the emergency room, and the determinants of disposition decision making. On the basis of their research, they suggest a model for emergency services that includes an evaluation of the patient's and his on her community's resources and competence and minimizes subtle diagnostic considerations.

Age Factors↗
PubMed1980

Chronic crisis patients: a discrete clinical group.

Patients who made repeated visits to a psychiatric emergency ward and who were studied appeared to comprise a discrete clinical group characterized by a distinct symptom profile, common psychiatric history, and similar styles of interacting with caretakers. They generally did not differ from nonrepeater patients with regard to acute symptomatology but were hospitalized more frequently. They were generally negativistic, had a lengthy psychiatric history consisting of multiple inpatient hospitalizations and current outpatient treatments, and had difficulty establishing rapport with the emergency ward therapists, often evoking intense feelings of dislike. The authors offer an approach to the management of these patients based on an understanding of their cycle of seeking and rejecting help.

Adult↗
PubMed1979

Into the breach: emergency psychiatry in the general hospital.

In its position at the interface between the community and the general hospital, the emergency ward (EW) serves to reconcile the complex needs of the local population with the traditional organizational structure of the hospital. In recent years, the EW has been faced with the dilemma of managing increasing numbers of psychotic patients with chronic illness and psychosocial problems. In response to this impressive growth in the utilization of psychiatric emergency services, a variety of general hospitals have developed model programs of service delivery and methods for the evaluation of their effectiveness. This paper is an overview of utilization patterns, organization of services, and assessment of the evaluation and referral model. This issues facing general hospitals in the development of emergency care are clarified. The need for further research, program development, and clinical implementation is discussed.

Crisis Intervention↗
PubMed1975

The parakeratin layer of zinc-deficient rat buccal epithelial.

Weanling rats were fed a zinc-deificient diet, 1.3 ppm zinc, for four weeks. Parakeratotic changes of the buccal epithelium were studied by electron microscopy. The incomplete disintegration of the nucleus and cytoplasmic organelles in the horny layer is deemed to be due to insufficient function of zinc-related lytic enzymes.

Animals↗
PubMed1975

Norepinephrine content of various rat organs after chronic administration of desmethylimipramine.

The effect of chronic oral administration of desmethylimipramine (DMI) on the norepinephrine (NE) content of various organs was examined in rats. The present results show that in contrast to its effect on the brain, where it lowered the NE concentration, chronically administered DMI either did not change (vas deferens) or tended to increase (heart and spleen) the NE concentrations in the examined peripheral organs. The effect of chronic DMI administration on the brain seems to be specific since this was the only studied organ in which a decreased NE concentration was observed.

Animals↗