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S Getz

Publications and source records attributed to S Getz.

5 recordsLinked to original sources

The gracilis free flap revisited: a review of 25 cases of transfer to traumatic extremity wounds.

Trauma to the extremities often results in a complex bony and soft-tissue injury requiring free flap reconstruction. Muscles from various body sites have been used in extremity reconstruction since the early 1970s. The gracilis muscle is usually not considered the first choice for free flap reconstruction of these defects. It is usually relegated to small defects or used to reanimate the face. Our purpose is to present our experience with the gracilis muscle as a first-choice flap in reconstruction of traumatic extremity defects. A retrospective review of all gracilis muscle free flap transfers for traumatic extremity wounds between 1988 and 1995 at the Naval Medical Center Portsmouth was performed. Twenty-five patients age 20 to 71 years (mean, 29.7 years) underwent 26 free flaps to the lower leg, ankle, foot, or forearm to cover traumatic wounds. Defects ranged in size from 3 x 3 cm (9 cm2) to 13 x 18 cm (234 cm2), with a mean of 75.5 cm2. There were no flap losses and all wounds healed. Nine patients experienced 11 complications, which consisted of minor wound separation (16%), wound infection (12%), partial or complete loss of split-thickness skin graft (8%), thrombosis of graft with successful revascularization (4%), and nonunion of an underlying fracture (4%). Our overall success rate for gracilis free flap reconstruction of traumatic wounds is 100%. The gracilis free muscle flap has become our first option for tissue coverage in traumatized extremities. It leaves minimal functional defect limited to the side of the primary injury and provides a good cosmetic result. It can cover large defects when the epimysium is cut, and allows an epidural block to be performed for sympathectomy effect and pain control in the affected extremity during the immediate postoperative period.

Adult↗

Effect of glucose concentration and time on polymorphonuclear leukocyte function.

Polymorphonuclear leukocyte (PMNL) to oxidative metabolism and functional activities were assayed after varying periods of exposure to glucose concentrations ranging from 100-600 mg/dl. Oxygen consumption, superoxide generation and phagocytosis and killing of radiolabeled S. aureus by PMNL were not affected by hyperglycemic conditions for incubation periods up to 18 hours. Elevated glucose levels per se do not appear to be responsible for PMNL abnormalities reported in patients with diabetes mellitus.

Diabetes Mellitus↗

Polymorphonuclear leukocytes of human colostrum. I. Oxidative metabolism and kinetics of killing of radiolabeled Staphylococcus aureus.

Polymorphonuclear leukocytes (PMNLs) were isolated from the colostrum of 57 women. Colostral cells were identified by fluorescent microscopy after supravital staining with acridine orange. Numerous intracellular fat globules within colostral PMNLs were shown by Oil Red O stain and electron microscopy. Oxidative metabolic activity during phagocytosis of opsonized zymosan particles was significantly greater in blood PMNLs compared with colostral PMNLs. The total uptake and killing of [methyl-3H]thymidine-labeled Staphylococcus aureus by blood PMNLs were significantly greater than by colostral PMNLs. Similar defects were produced in blood PMNLs incubated with the lipid fraction of colostrum, but not in those incubated with the aqueous fraction. Surface Fc receptors of colostral PMNLs and blood PMNLs incubated with colostral lipid were significantly reduced in number compared with those of control PMNLs or PMNLs preincubated with the aqueous fraction of colostrum. The metabolic and phagocytic defects of PMNLs from human colostrum appear to be related to colostral substances that alter PMNL surface structure and subsequent function.

Cell Count↗

Hyperthermic effects on DNA repair mechanisms.

Studies have been carried out using neutral and alkaline sucrose density gradients to investigate the effect of 41 degree-43 degree C on the ability of Chinese hamster ovary cells to repair single (SSB) and double stranded DNA breaks (DSB) caused by exposure to ionizing radiation. The authors found that when hyperthermia exists prior to irradiation significant inhibition occurs. The data support the conclusion that unrepaired DNA damage may be lethal to the cell. Though no increase in radiation-induced DSB frequency was observed subsequent to hyperthermia, a 10-20% increase in SSB frequency was observed.

Animals↗