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Biomedical subjects

S Gill

Publications and source records attributed to S Gill.

At least 91 records · Page 5Linked to original sources
PubMed1982

Nalidixic acid inhibits the conjugal transfer of conjugative N incompatibility group plasmids.

The conjugal transfer of R plasmids of the N incompatibility group was inhibited by nalidixic acid to the same degree as that of plasmids of other conjugative and incompatibility groups. Inhibition was reversible. This supports a belief that nalidixic exerts its effect by interfering with a step(s) that is common to all conjugative systems among Enterobacteriaceae. These observations do not support an earlier suggestion that motivated the present study, and a reason for this is suggested.

Conjugation, Genetic↗
PubMed1982

Modulation of cytarabine metabolism in the human promyelocytic leukemia cell line HL-60 by polyhydroxy-substituted benzohydroxamic acids.

Two potent new ribonucleotide reductase inhibitors, 3,4,5-trihydroxybenzohydroxamic acid (VF 122) and 3,4-dihydroxybenzohydroxamic acid (VF 147), were investigated for their ability to modulate the cellular pharmacology of cytarabine (ara-C) in HL-60 cells. VF 122 and VF 147 increased the total cellular uptake of ara-C by a mean (+/- SE) of 8% +/- 3% and 29% +/- 3%, respectively, when measured 2 hours after the start of exposure to 0.1 microM ara-C. This effect was evident after only 10 minutes of exposure to the riboNucleotide reductase inhibitor and did not vary significantly over the concentration range of 10-100 microM for either agent. VF 122 enhanced the incorporation of ara-CTP into DNA by 3.6-fold; VF 147 produced a 5.6-fold increase. In comparison, the maximum enhancement achievable with hydroxyurea was 2.1-fold, and with thymidine was 1.8-fold. These results provide a biochemical rationale for further investigation of these agents in combination with ara-C.

Cell Line↗
PubMed1978

Infective aneurysm of the left ventricle: angiographic and echocardiographic features.

A 17-year-old man with staphylococcal endocarditis of the mitral valve developed an infective aneurysm of the posterior left ventricular wall. Echocardiography revealed an echo-free space posterior to the posterior left ventricular wall. This echo-free space undoubtedly represented the aneurysmal sac, because it could be temporarily obliterated by injecting saline into it and was no longer detectable following surgical closure of the sac. Thus echocardiography may be helpful in the detection of an infective aneurysm of the left ventricle.

Adolescent↗
PubMedDate not supplied

Satisfaction with nursing care: a comparison of patients with HIV/AIDS, non-HIV/AIDS infectious diseases, and medical diagnoses.

The purpose of this study was to describe patients' perceptions of nursing care and compare those perceptions based on patients' diagnoses (HIV/AIDS, non-HIV/AIDS infectious diseases, and medical diagnoses). One hundred forty-two patients on five units in a major medical center were surveyed using the Patient Satisfaction Instrument. In addition, 126 staff nurses completed the AIDS Vulnerability Survey. Results of data analysis indicated a statistically significant difference in patient satisfaction with nursing care among patients in the medical group compared to patients in the HIV/AIDS group, with the medical group being more satisfied with their nursing care. Further, there was a statistically significant difference across units between nurses' knowledge, attitude, and fear. In spite of their knowledge base related to HIV/AIDS, nurses felt vulnerable when providing care to this population, thus perpetuating fear and negative attitudes. Additional research into the dynamics of these relationships is imperative as we continue to see increases in the number of patients with HIV/AIDS.

Adult↗
PubMedDate not supplied

Determination of optimal peat type to potentially capture copper and cadmium from solution.

The focus of this study was to determine the optimum type of peat for application as a medium to capture dissolved metals from aqueous solution. Seventeen media were examined, including eleven Irish peat samples from various locations and stages in processing, a Northern Ireland lignite, peat and lignite chars, a commercial-grade bone char, and two commercial-grade granular activated carbons. Considerable variation in sorption capacity was found with a ratio of 20:1 between the best-performing (bone char) and the poorest-performing (peat char) samples. Among the 14 varieties of peat, the best-performing sample outperformed the commonly investigated sphagnum moss by a ratio of 4:1. A correlation has been established between cation exchange capacity, the presence of adsorbed calcium, and the uptake capacity of different peats. This correlation will be a valuable tool in choosing peat type for filter media for metals removal applications.

Adsorption↗