Biomedical subjects

S Giuri

Publications and source records attributed to S Giuri.

14 recordsLinked to original sources

PubMed2004

[Combined hamartoma of the retina and retinal pigment epithelium].

We report the case of a 31-year-old man who developed a combined hamartoma of the retina and retinal pigment epithelium in the left eye. The diagnosis was determined based on alterations discovered on fundus examination: hyperplasia of the retinal pigment epithelium cells and tortuosity of the vessels and glial epiretinal membrane. These modifications made it possible to differentiate the hamartoma from choroidal melanoma. The patient underwent photocoagulation therapy. His death due to stroke 4 years after therapy made it possible to analyze the eyeball. Histopathological examination revealed alterations due to retinal photocoagulation as well as alterations particular to the primary tumor: hypertrophy of the retinal pigment epithelium and glial and vascular overgrowth.

Adult↗

PubMed2003

[Conjunctival-palpebral Kaposi's angiosarcoma: report of a case].

We describe the case of a 71-year-old man who developed classic Kaposi's sarcoma with conjunctival-palpebral involvement. The diagnosis was made based on clinical and histopathological findings. The lesions of the palpebral and conjunctival teguments were of a nodular tumorous aspect, their clinical particularities similar to other tegumental involvement. The clinical elements, histopathology, and pathogenesis are debated. The effects of local therapy, consisting of intralesional injections with alpha interferon and cryotherapy, were transient.

Aged↗

PubMed2002

[Cutaneous palpebral anthrax].

The interest for anthrax is permanent because of its difficult diagnosis, its severe prognosis, and the possibility of its dissemination during biological war and bioterrorism. Cutaneous anthrax is an infectious disease caused by Bacillus anthracis. Palpebral localizations are rare, raising problems of differential diagnosis. The case of a 21-year-old male with palpebral anthrax is presented. The diagnosis was established by the progression of the palpebral lesions (serohemorrhagic vesicle, black necrotic eschar), extended palpebral edema, and positive epidemiological data. During the onset period, the differential diagnosis was difficult because of uncharacteristic symptoms, negative bacteriological tests (previous antibiotic treatment), and the absence of epidemiological data. Treatment with G penicillin led to the patient's cure.

Adult↗

PubMed2001

[Myelinated nerve fibers associated with cilioretinal artery occlusion].

Although the myelinated nerve fibers are considered as benign, cases associated with retinal vascular abnormalities (telangiectasis, neovascularization, vascular occlusions) have recently been reported, suggesting a possible pathogenic correlation between these elements. Our observation presents a 44-year-old patient, with a sudden decrease of visual acuity in the right eye, discal and peridiscal myelinated nerve fibers, associated with cilioretinal artery occlusion. The general clinical and laboratory examination, except for a drug stabilized arterial hypertension, did not reveal other local or general embolic factors. One year later, the decrease in visual acuity had remained unchanged and the area of the myelinated nerve fibers had diminished. Based on the association between the myelinated nerve fibers, the cilioretinal artery occlusion, the young age of the patient, and the absence of other local or general embolic factors, we consider there is a possible pathogenic correlation between these elements. The action of the myelinated nerve fibers can be explained by a mechanical compression, with the disruption of the cilioretinal artery route, a structurally vulnerable artery.

Adult↗

PubMed2001

[Myelinated nerve fibers associated with juxtapapillary haemorrhages].

The myelinated nerve fibers (MNF) are o congenital anomaly characterized by the extension of the myelinisation process anterior from the lamina cribosa. The incidence of myelinated nerve fibers is 0.3-0.6% in patients and 0.54% in eyes from autopsies. Although these represent benign lesion, rarely are associated with retinal abnormalities: vascular abnormality (retinal telangiectasis, cranial-facial lesions, coloboma of the iris, keratoconus, myopia/strabismus, amblyopia). Myelinated nerve fibers asSociated with juxtapapillary haemorrhages was not reported in the available literature. We describe the clinical findings and diagnostic particularities of myelinated retinal nerve fibers associated with juxtapapillary haemorrhages in a personal case. An 40-year-old woman was referred for unilateral papillary abnormalities. The diagnosis was myelinated retinal nerve fibers as white striated patches with feathery edges, associated with two juxtapapillary haemorrhages. The clinical and pathogenic features are discussed. Based on the association between the myelinated nerve fibers, the juxtapapillary haemorrhages there is a possible pathogenic correlation between these elements. The action of the myelinated nerve fibers can be explained by a mechanical compression, with the disruption of the retinal artery, a structural vulnerable artery.

Adult↗

PubMed2000

[An efficacy study of lodoxamide treatment in allergic eye lesions].

Lodoxamid is an antiallergic drug, which stabilizes the mast cells' membrane blocking the release of the type I hypersensitivity reaction chemical mediators. A number of 25 patients with ocular allergic diseases (allergic conjunctivitis, vernal and atopic keratoconjunctivitis, giant papillary conjunctivitis), were included in this study. Lodoxamid, solution 0.1% (Alomide), was given 4 times daily for 6 weeks. The study's aim was to assess the lodoxamid's efficiency, on the ocular signs and symptoms. The study's results showed a significant improvement, or the disappearance of the ocular allergic disease. It is debated upon the lodoxamid's way and place of action, in blocking the type I hypersensitivity reaction. The lodoxamid's efficiency is due to its pharmacological features, by means of which it is effective on many links of the pathogenic chain: mast cells, eosinophils, lymphocytes, neutrophils, antigen presenting cells. Due to its action lodoxamid stabilizes the mast cell's membrane, and inhibits the release of histamine, prostaglandins, leukotrienes, triptase, interleukines -4, -8 and TNF-. During therapy with lodoxamid recruitment and activation of eosinophils is decreased, causing a significant reduction of the basic major protein, cationic eosinophilic protein, eosinophilic derived neurotoxin, eosinophilic peroxidase. Lodoxamid reduces the expression of ICAM-1 on the surface of the antigen presenting cells, and decreases the number of the TH2 cells, from the tears of the allergic patients.

Adolescent↗

PubMed2000

[Colobomatous pits of the optic nerve papilla associated with serous retinal detachment. The clinical and pathogenic aspects].

The present study is about a number of 19 cases (19 eyes), the patients having a congenital pit of the optic papilla (CPP) complicated with serous retinal detachment (SRD). The cases were selected, from a group of 41 patients with CPP. Average age of the cases was 37(31-54) years. The serous retinal detachment appeared under two different clinical appearances: the detachment of the internal retinal layers (DIRL) or retinal schisis, 10 cases, located between the papillae and macula, and involving the optic disc; the detachment of the external retinal layers (DERL), 9 cases, located within the macular area, without involvement of the optic disc. A number of 8 cases (42%) developed a macular hole, located within the external retinal layers. The cases with DIRL had better visual acuity, compared to those with DERL. This study proves the bilamellate character, of the serous retinal detachment. The disease starts with DIRL (retinal schisis), due to fluid passing at the level of the CPP and then DERL develops as a complication, following the degenerescence of the retinal layers within this area.

Adult↗

PubMed1999

[Ocular cicatricial pemphigoid].

The scarry ocular pemphigoid, is an autoimmune disease, belonging to the category of the acquired oculo-muco-cutaneous bullous dermatosis. The ocular symptoms, during the acute stage are conjunctival bullae, which evolve quickly into ulcerous lesions. During the chronic stage, the disease consists of a chronic scarry conjunctivitis, accompanied by corneal lesions, ocular dryness syndrome, disturbances of the palpebral statics and dynamics. The immunopathological mechanism, is represented by a type II hypersensitiveness reaction, in which the antigen-antibody-complement interaction, takes place at the level of the conjunctival epithelium basement membrane. We have reviewed the structures with antigenic potential: the antigen of the bullous pemphigoid-2, 5-6 laminin, beta 4 integrin. The participation of the immunoregulating cells (eosinocytes, mast cells, neutrocytes, macrophages) during the acute stage of the disease, is displayed. The key role of the activated fibroblasts, in producing the subepithelial fibrosis, during the chronic stage of the scarry ocular pemphigoid, is also underlined.

Autoimmune Diseases↗

PubMed1998

[Corneal ulcerative lesions in type-I immediate hypersensitivity].

The vernal keratoconjunctivitis (KCV) is included within the category of the hypersensitiveness diseases, the immunopathological mechanism which causes the disease being represented by a type-I hypersensibility reaction. The mechanism which determines the appearance of the corneal lesions isn't entirely cleared up, but there are however some pathogenic links which have been already deciphered. The type I hypersensibility reaction is taking place within two stages: stage I the stage of the sensitizing contact and stage II the stage of the unleashing contact. During the first stage, the Langerhans cells take over and process the allergen, exhibiting on their surface only the antigenic part. The Langerhans cells interact with the T helper native cells (Tho), cells from which there will result the predominantly differentiated Th2 subtype. The Thz cells will activate, by means of the interleukines, the B cells (which produce the IgE), the mast cells and the eosinophilic cells. During the second stage, the allergen is coming into contact with the IgE specific antibodies, which are fastened on the mast cells membrane, generating the opening of their granules. The result of this evolution is represented by the unleash of vasoactive mediators, own enzymes, chemical mediators (among which there is also the eosinophilic chemotactic factor ECFA). The latter contributes to the infiltration of the epithelial and of the subepithelial tissue with eosinophilic cells. The major basic protein (PBM), one of the proteins released from the eosinophilic cells' big granules, plays a major pathogenic role in the production of the corneal ulcer, by means of its direct cytotoxic effect and also by means of inhibiting the migration of the epithelial corneal cells. The role of the mast cells and also the role of the neutrophile cells within the framework of the pathogenesis of the ulcer is disputable, because some specific enzymes tryptase, respectively elastase--have been found within the debris of the corneal ulcer. The allergic keratoconjunctivitis (KCA) represents the ocular manifestation of the systemic hypersensitiveness. In the beginning the immunopathogenic mechanism which causes the lesions is represented by a type-I hypersensibility reaction, but during its evolution, the characteristic histopathological changes (chronic granulomas, perivascularitis, subendothelial fibrosis) are suggesting a complex immunoregulatory disfunction.

Conjunctivitis, Allergic↗

PubMedDate not supplied

[Cerebro-oculofacial dysplasia associated with vertebral changes].

A clinical case of craniofacial dysplasia, with multiple and complex congenital anomalies, is presented. The clinical modifications noticed are systematized in four groups: cerebral, ocular, facial and vertebral. The case is a form of cerebrofacial display, associated with anophthalmos, orbitopalpebral chist and vertebral modifications. There are discussed problems of differential diagnosis, pathogeny and therapeutical attitude.

Abnormalities, Multiple↗

PubMedDate not supplied

[Choroidal metastasis after a bronchial carcinoid tumor].

59-year-old patient present at the left eye a symptomatic retinal detachment, angiofluorographic and ultrasonographical confirmed. The histopathological exam, made after the globe enucleation, revealed a tumoural formation having the structure of the squamocellular carcinoma. The general clinical investigations showed neoplastic lesions at the level of the right lung. The patient was directed to the oncology department with the diagnosis of choroidal metastasis at the left eye, after bronchial carcinoid tumour.

Bronchial Neoplasms↗

PubMedDate not supplied

[Screening for diabetic retinopathy in Romania].

The survey proposes the analysis of the Romanian implementation of the action: "Protocol for screening of diabetic retinopathy in Europe" (London, 1990). Based on the answers obtained after spreading a typical questionnaire, it was constated that the protocol's implementation was done in 9 sanitary profilated units and implied a percentage of patients less then 4%. Some of the difficulties mentioned were the insufficiency of (photocoagulation) devices, of funds and adequate (qualified) staff, and also the inertia of the old evidencing system.

Diabetic Retinopathy↗

PubMedDate not supplied

[Chronic ischemic ophthalmopathy in Takayasu-Onishi disease].

The cronical ischemical ophthalmopathy represents an ocular clinical syndrome with well-defined clinical particularities. It is the effect of the decrease of the perfussion pressure at ACR level, during a long time period, caused by the stenosis of the aortic arch and his main branches. The paper presents a clinical observation of cronical ischemical ophthalmopathy having in ethiology the unspecific aortitis or the Takayasu-Onishi diasease. It is extensively discussed the ocular clinical syndrome and the particularities of the Takayasu-Onishi disease.

Chronic Disease↗

PubMedDate not supplied

[The ocular manifestations in Felty's syndrome].

The Felty syndromme is a rare clinical form of the rheumatoid poliarthritis, which involves, besides the articular manifestations specific to the latter, other manifestations such as: splenomegalia with hypersplenism, poliadenopathy, ulcerations at the low leg level and skin pigmentation. In some cases, the Felty syndromme may be associated with ocular modifications: episcleritis, nodular scleritis, corneal ulcer, Sicca syndromme, iridocyclitis, retineal vasculite. A clinical observation of Felty syndromme associated with ocular modifications is presented. Some aspects regarding the nosologic classification of Felty syndromme, its clinical and ethiopathogenical particularities are discussed; the accent is put on the immunopathological component. The ocular modifications particularities, their diagnosis and the therapeutical aspects are presented.

Aged↗