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Biomedical subjects

S Giustiniani

Publications and source records attributed to S Giustiniani.

15 recordsLinked to original sources

[Arrhythmogenic right ventricular myocardiopathy. A study of a family group].

In this paper, we report the cases of 4 male patients (mean age 32.7 yr) with right-ventricular dysplasia, that occurred in familial form. Diagnosis was possible according to the clinical features and to the electrocardiographic, echocardiographic and scintigraphic criteria; at Holter monitoring recorded ventricular arrhythmias with left bundle branch block configuration, associated to sinus arrhythmias (sino-auricular block). In two patients a sustained ventricular tachycardia was recorded. The patients are living and a fourteen-year-old subject is without heart disease. From our data we conclude that: the most serious clinical features occur in extensive form with right atrial and left-ventricle involvement; the clinical features were manifested at a young age and then got worse. A dominant autosomic inheritance is observed (only males were affected).

Adolescent

Hyperplastic gingivitis during diltiazem therapy.

This report concerns a patient with ischemic heart disease, who developed hyperplastic gingivitis with verapamil. The gingivitis resolved completely when the drug was discontinued, but recurred when another calcium antagonist, diltiazem, was administered. It is suggested that it is the mechanism of action of calcium antagonists which is responsible for the gingival changes.

Calcium Channel Blockers

[Hypertrophic gingivitis caused by verapamil].

We observed gingival hyperplasia, similar clinically to the hyperplasia caused by diphenylhydantoin during the last 11 months in two patients treated by verapamil, suffering from angina pectoris pains. In Case I discontinuation of the calcium antagonist resulted in marked regression of the gingival hyperplasia. Evidence points to a strong relationship between the gingival hyperplasia and the administration of verapamil. Further studies are required to confirm definitively the relationship between the administration of verapamil and gingival hyperplasia, its incidence, and the correlation with local factors.

Angina Pectoris

[Mitral valve prolapse in patients with coronary artery insufficiency. Report of two unusual cases (author's transl)].

The authors illustrate two peculiar cases of mitral valve prolapse in patients with coronary artery disease. The first case reports a mitral valve prolapse that, absent in basal conditions, is unmasked by a premature ventricular beat. In the second case concerns about the manifestation of a mitral valve prolapse developed during the course of retrosternal chest pain.

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