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Biomedical subjects

S Gleichmann

Publications and source records attributed to S Gleichmann.

11 recordsLinked to original sources
PubMed1998

[Changes in life style as a causal therapeutic approach in coronary heart disease].

Life style measures (weight reduction and control, reduction of total fat calories to < 30% of total calories, modification of fat intake to increased monounsaturated vegetable fat, increased intake of dietary fibers, increased physical activity, controlled stress relaxation) are the basis of longterm therapy of coronary heart disease. For transformation to daily life both patient and doctor need motivation, information, patience, and realistic aims. For realization the 10 rules of medical information should be followed. The patient must be informed that the "new lifestyle" is not punishing but means a new quality of life. With respect to the most important metabolic syndrome with hyperinsulinemia due to insulin resistance, weight reduction is the most important measure for preventing complications of atherosclerosis. The patient should use a diary for weight control and blood pressure self-measurement. Secondary prevention of CHD has been shown useful and effective; however, most patients need additionally drug therapy to avoid or retard progression of the coronary heart disease. The targets for cholesterol and blood pressure control are low; the responsibility of the patient remains high. Besides weight reduction, stopping smoking, lowering lipids, controlling hypertension, and aspirin are the most important.

Coronary Disease↗
PubMed1997

[Living lighter].

Explore the source record for details and available documents.

Combined Modality Therapy↗
PubMed1996

Automated blood pressure measurement in special situations: patients with chronic atrial fibrillation or chronic aortic regurgitation.

Fully-automated blood pressure measurement has become increasingly widespread over the last few years, especially in the field of blood pressure self-measurement. The high prevalence of arterial hypertension among the aged (over 30%) means that, frequently, the users additionally suffer from cardiac irregularity and valvular heart disease. Using comparative, invasive blood pressure measurements, we investigated the reliability and accuracy of the currently authorized blood pressure measuring devices, both in patients with the most common cardiac irregularity, atrial fibrillation, and in patients with aortic regurgitation, as an example of blood pressure measurement in connection with hypercirculation. Certain things must be taken into account when carrying out auscultatory blood pressure measurement according to Riva-Rocci and Korotkoff if blood pressure levels are to be determined accurately. Firstly, considering the individual variability of blood pressure levels in connection with atrial fibrillation, the mean value from three consecutive blood pressure measurements is more accurate than a single measurement. Secondly, the diastolic blood pressure of patients with significant aortic regurgitation should always be determined with Phase 4 according to Korotkoff. In patients with atrial fibrillation, the accuracy of the blood pressure devices being considered should be investigated individually. In comparison, devices employing the oscillometric measuring technique for blood pressure self-measurement in the upper arm determine blood pressure levels more accurately and reliably than devices for measurement in the wrist or auscultatory devices. In patients with significant aortic regurgitation, diastolic blood pressure levels determined with currently authorized, fully-automated blood pressure measuring devices are reliable and accurate. Systolic blood pressure levels determined in the upper arm are, however, too high.

Adult↗
PubMed1996

Blood pressure self-measurement in upper arm and in wrist for treatment control of arterial hypertension compared to ABPM.

Automatic 24 h Ambulatory Blood Pressure Monitoring (ABPM) has become an established method in the diagnosis and treatment control of arterial hypertension. Fully automatic blood pressure devices for blood pressure self-measurement (BPSM) in the upper arm and in the wrist using the oscillometric measuring technique have been available in Germany for several years. After evaluating the blood pressure devices boso Oscillomat (upper arm) and Omron HEM-601 (wrist) by means of simultaneous invasive measurements, we studied the suitability of this new method for the control of treated hypertension. Using the device Space Labs 90207, we had ABPM carried out in 100 men (aged 58 +/- 8 years) with mild to moderate hypertension. They recorded hourly blood pressure measurements in the wrist between 6 a.m. and 6 p.m., in the same arm as the blood pressure monitoring using the device Omron HEM-601, or in the other arm using the device boso Oscillomat. The values of systolic and diastolic blood pressure were measured using both methods. Since the random samples probably consisted of non-standard distribution differences, we applied the Wilcoxon matched pairs signed rank test for statistical analysis. No significant differences were recorded between the daily mean systolic (p < .07) and diastolic (p < .97) blood pressure values determined by ABPM and by frequent blood pressure self-measurement. Multiple blood pressure readings obtained using blood pressure self-measurement in the upper arm as well as in the wrist are an alternative to the established, automatic 24-h, ambulatory blood pressure measurement for the treatment control of arterial hypertension, that nightly blood pressure measurement can be omitted. It has advantage of unrestricted and desired frequent use under standardized conditions.

Adult↗
PubMed1989

[Optimal long-term control of arterial hypertension. Experiences with ambulatory, sports-oriented groups of patients with hypertension].

Out-patient groups of hypertensives were organized in an effort to improve long-term treatment results with greater attention to general measures and to increase compliance. Under supervision of a doctor and a physiotherapist 45 patients (aged 54 +/- 10 years) with mild or moderately severe hypertension were enrolled in a sports training programme after thorough examination. At the same time they were given advice and instructions on self-measurement of blood pressure, diet, medication, general life style and relaxation techniques. In the first 20 patients (observation period of more than one year) a significant reduction in both resting (systolic of -9%) and exercise (systolic of -12%) blood pressures was noted. At the same time exercise tolerance was raised (+18%), while body-weight and total cholesterol concentrations were lowered. It was possible to reduce drug dosage in seven patients, in three more it was discontinued. Left-ventricular wall thickness fell slightly but not significantly. There were no complications. It is concluded that group therapy with sport as a vehicle and advice on general life style are satisfactory means for controlling hypertension and achieve better compliance.

Adult↗
PubMed1984

[Prevention of coronary heart disease--practical viewpoints].

The recently published intervention studies have shown that effective prevention of coronary artery disease can be done by risk factor modification. Identification and care for patients with higher risk is a challenge for the attending physician. He should focus his attention on the three major risk factors: hypertension, hypercholesterinemia and smoking. Normalisation of eating behaviour is the basis in the treatment of hypertension and hypercholesterinemia. For smoking cessation family members should also be advised to stop smoking, too. An effective reduction in the risk profile by life style changes can only be achieved if a good relation between patient and physician can be established.

Cholesterol↗
PubMed1977

Quantum-chemical and empirical calculations on phospholipids, III. Hydration of the dimethylphosphate anion.

The binding of water to the dimethylphosphate anion (DMP-) was calculated using the PCILO method. We found binding energies of 25.95 kcal-mol-1 in the O1-P-O3 plane bridgeing the anionic oxygen atoms and 19.3 kacl-mol-1 for the one-site association of a water molecule to an anionic oxygen atom of DMP-. In this range on water molecule added to DMP- in the O1...O3 bridged configuration has a significantly higher binding energy to DMP- than water molecules added to other binding sites. The total binding energy of 5 water molecules to DMP- is 92 kcal-mol-1, a quantity which is about 10% less than the sum of the binding energies of the corresponding monohydrates.

Binding Sites↗