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Biomedical subjects

S Gou

Publications and source records attributed to S Gou.

12 recordsLinked to original sources
PubMed2000

[Computerized surgical simulation with 3D reconstruction of upper limbs].

This paper reports our study on how to realize computerized surgical simulation through reconstructing 3D anatomy of upper limbs. CT images and serial sections of upper limbs were matched to reconstruct 3D images. We compiled the computer programs of 3D reconstruction and surgical simulation with borland C++ computer language, and built 3D digital model of anatomic structure of upper limbs. The results showed that all structures reconstructed could be displayed alone, in any group or totally. While operating, we could choose one of three segments of the upper limbs model and operate on any parts and in any direction. The surgical simulation system could be used to design operative schemes, choose the best operative paths, and teach the processes of operations and anatomy. It could run in 586-personal computers.

Arm↗
PubMed1998

[Experimental study of the effect on growth of Schwann cell from chitin and chitosan in vitro].

In order to study the effect of chitin and chitosan on the growth of Schwann cell (SC) of rats in vitro, the SC was isolated from sciatic nerve and brachial plexus of new-born rats. After the enzymatic and mechanical dissociation, the cell suspension was vaccinated on chitin membrane and chitosan fluid-coated glass coverslips. Then, the growth of SC was examined at 1, 3, 7 days after culture under light microscope and scanning electron microscope. The results showed that 94 percent of the cell grown from was SC and only 6% was fibroblast (FB), while that of the control SC 71% and FB 29% in population. The number of SC in chitosan suspension was more than that in chitin. Therefore, the conclusion was that the chitin and chitosan was histocompatible to SC, and chitosan suspension was superior to chitin, and both could inhibit the growth of fibroblast.

Animals↗
PubMed1998

[Distal clavicular fracture and dislocation of acromino-clavicular jiont treated with biopoly ligament].

OBJECTIVE: To probe into distal clavicular fracture and acromino-clavicular joint dislocation treatment. METHODS: 11 cases of distal clavicular fracture and 20 cases of acromino-clavicular joint dislocation were treated with biopoly ligament in recent 2 years. The follow-up period lasted from 3 to 24 months with an average of 16.7 months. RESULTS: Of 29 follow-up cases, 21 were excellent and 8 satisfactory. There was no redisplacement or refracture. CONCLUSION: Biopoly ligament is believed to be a good and safe material for this fracture or dislocation. This method is simple without needing a second operation for removal of implant.

Acromioclavicular Joint↗
PubMed1997

[A preliminary report on clinical application of biopoly ester ligament].

Sixty-one cases of fracture or dislocation were treated with France-made biopolyester ligament. They consisted of 18 cases of fracture of patella, 13 cases of fracture of olecranon, 8 cases of fracture of distal clavicle, 10 cases of dislocation of acromino-clavicular joint, 6 cases of separation of lower tibio-fibular joint, 3 cases of rapture of cruciate ligament and 3 cases of fracture of upper third of ulna with dislolcation of radial head. The follow-up period lasted from 3 to 12 months with an average of 7.3 months. The result showed that of the 56 follow-up cases, 49 were excellent and 7 were satisfactory. There was no redisplacement occured in this group. The Biopolyester ligament was believed to be a good and safe material for fractures or dislocations and was of good strength of extension and easy to use.

Adolescent↗
PubMed1996

A survey of FRAXE allele sizes in three populations.

FRAXE is a fragile site located at Xq27-8, which contains polymorphic triplet GCC repeats associated with a CpG island. Similar to FRAXA, expansion of the GCC repeats results in an abnormal methylation of the CpG island and is associated with a mild mental retardation syndrome (FRAXE-MR). We surveyed the GCC repeat alleles of FRAXE from 3 populations. A total of 665 X chromosomes including 416 from a New York Euro-American sample (259 normal and 157 with FRAXA mutations), 157 from a Chinese sample (144 normal and 13 FRAXA), and 92 from a Finnish sample (56 normal and 36 FRAXA) were analyzed by polymerase chain reaction. Twenty-seven alleles, ranging from 4 to 39 GCC repeats, were observed. The modal repeat number was 16 in the New York and Finnish samples and accounted for 24% of all the chromosomes tested (162/665). The modal repeat number in the Chinese sample was 18. A founder effect for FRAXA was suggested among the Finnish FRAXA samples in that 75% had the FRAXE 16 repeat allele versus only 30% of controls. Sequencing of the FRAXE region showed no imperfections within the GCC repeat region, such as those commonly seen in FRAXA. The smaller size and limited range of repeats and the lack of imperfections suggests the molecular mechanisms underlying FRAXE triplet mutations may be different from those underlying FRAXA.

Alleles↗
PubMed1994

Distribution of FMR-1 and associated microsatellite alleles in a normal Chinese population.

The CGG repeat size distribution of the fragile X mental retardation gene (FMR-1) was studied in a population of normal Chinese X chromosomes along with that of two proximal microsatellite polymorphic markers: FRAXAC1 and DXS548. The most common CGG repeat allele was 29 (47.2%) with 30 being second most common (26%). This distribution was different from that seen in Caucasian controls, where the most common allele was 30 repeats. Other differences with Caucasian controls included a secondary modal peak at 36 repeats and the absence of peaks at 20 or 23 repeats. There were only two FRAXAC1 and five DXS548 alleles found in the Chinese sample. A striking linkage disequilibrium of FMR-1 alleles with FRAXAC1 alleles was observed, in that 90% of the 29 CGG repeat alleles but only 41% of the 30 CGG repeat alleles had the FRAXAC1 152 bp allele (18 AC repeats). This disequilibrium suggests that slippage between the closely spaced normal CGG repeat alleles, 29 and 30, and between 152 and 154 FRAXAC1 alleles is very rare. This study lays the groundwork for an understanding of founder chromosome effects in comparing Asian and Caucasian populations.

Alleles↗