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Biomedical subjects

S Grad

Publications and source records attributed to S Grad.

13 recordsLinked to original sources
PubMed2000

Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary oedema.

In order to investigate whether vascular endothelial growth factor (VEGF) and inflammatory pathways are activated during acute hypobaric hypoxia in subjects who are susceptible to high-altitude pulmonary oedema (HAPE-S), seven HAPE-S and five control subjects were exposed to simulated altitude corresponding to 4000 m in a hypobaric chamber for 1 day. Peripheral venous blood was taken at 450 m (Zürich level) and at 4000 m, and levels of erythropoietin (EPO), VEGF, interleukin-6 (IL-6) and the acute-phase proteins complement C3 (C3), alpha1-antitrypsin (alpha1AT), transferrin (Tf) and C-reactive protein (CRP) were measured. Peripheral arterial oxygen saturation (SaO2) was recorded. Chest radiography was performed before and immediately after the experiment. EPO increased during altitude exposure, correlating with SaO2, in both groups (r = -0.86, P < 0.001). Venous serum VEGF did not show any elevation despite a marked decrease in SaO2 in the HAPE-S subjects [mean (SD) HAPE-S: 69.6 (9.1)%; controls: 78.7 (5.2)%]. C3 and alpha1AT levels increased in HAPE-S during hypobaric hypoxia [from 0.94 (0.11) g/l to 1.07 (0.13) g/l, and from 1.16 (0.08) g/l to 1.49 (0.27) g/l, respectively; P < 0.05], but remained within the clinical reference ranges. No significant elevations of IL-6, Tf or CRP were observed in either group. The post-exposure chest radiography revealed no signs of oedema. We conclude that VEGF is not up-regulated in HAPE-S and thus does not seem to increase critically pulmonary vascular permeability during the 1st day at high altitude. Furthermore, our data provide evidence against a clinically relevant inflammation in the initial phase of exposure to hypoxia in HAPE-S, although C3 and alpha1AT are mildly induced.

Acute-Phase Proteins↗
PubMed1999

VEGF levels in asthmatic airways do not correlate with plasma extravasation.

BACKGROUND: Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma in which oedema is an important feature. METHODS: We studied VEGF, albumin and IgA immunoreactive levels in the BAL fluids obtained from 27 chronic stable asthmatics, nine untreated chronic bronchitis patients and 15 control subjects. RESULTS: BAL fluid levels of VEGF and VEGF normalized to IgA were not significantly different in any patient group. Both asthmatic steroid- and non-steroid-treated groups had significantly lower albumin levels in their BAL fluids explaining most of the 179% increased VEGF normalized to albumin ratios in non-steroid treated asthmatics. Moreover, VEGF and albumin markers correlated in control subjects (r = 0.73, P = 0.006) and in chronic bronchitics (r = 0.75, P = 0.03, Spearman test), but not in asthmatics. VEGF was inversely correlated with asthma severity (GINA/NHLBI scores) in non-steroid treated asthmatics (tau = - 0.52, P = 0.009, Kendall test). CONCLUSIONS: Thus, the potential role of VEGF in asthma requires further studies on bronchial biopsies and induced sputum.

Adult↗
PubMed1998

Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn.

Angiogenesis is a key component of the repair mechanisms triggered by tissue injury. Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis, as it acts directly and specifically on endothelial cells. VEGF produced locally in regenerating tissue may spill over into the systemic circulation, and measuring levels of circulating VEGF may allow monitoring of angiogenesis. To determine whether circulating VEGF is increased after severe injury, we measured concentrations of VEGF in serial serum samples of 23 mechanical burn patients, 55 patients with multiple trauma and 56 healthy normal controls, using a newly established ELISA assay. In burn patients, serum VEGF was increased on day 1 (369.4 +/- 88.0 pg/ml) and on day 3 (452.0 +/- 65.3 pg/ml), reached highest levels on day 14 (1809.5 +/- 239.7 pg/ml) and was still elevated on day 21 post-burn (1339.8 +/- 208.7 pg/ml) (mean +/- SEM, p < 0.01), when compared with healthy controls (82.2 +/- 10.8 pg/ml (mean +/- SEM)). Likewise, in trauma patients, serum VEGF showed a trend towards elevated values on the day of admission (186.9 +/- 43.9 pg/ml) and on day 3 after injury (193.2 +/- 62.1 pg/ml). Thereafter, serum VEGF increased further (day 7,507.0 +/- 114.7 pg/ml), peaked on day 14 (742.4 +/- 151.8 pg/ml) and was still elevated on day 21 after injury (693.1 +/- 218.6 pg/ml (mean +/- SEM, p < 0.01)). No significant correlation was observed between peak serum VEGF and initial severity of mechanical (Injury Severity Score) or burn injury (percentage of body surface burned). However, in both burn and trauma patients, the subgroup of patients with uncomplicated healing showed significantly higher increases of serum VEGF than the subgroup who developed severe complications during the post-traumatic course, such as sepsis, adult respiratory distress syndrome or multiple organ failure (p < 0.05). Thus, markedly enhanced levels of serum VEGF are present one to three weeks after trauma or burn injury. Further, occurrence of severe complications during the post-traumatic period is associated with lesser increases of serum VEGF.

Adolescent↗
PubMed1990

Income change at retirement.

Less than one-fourth of SIPP retirees made the transition from full-time work and no benefit receipt to benefit receipt and no work during the 32 months of the 1984 SIPP panel, and these full retirees appear to differ economically from those who had not fully retired during the 32 months. Income declined to 60 percent of preretirement levels for those who received Social Security benefits and employer pensions, and to 46 percent for those who received only one type of benefit after ceasing full-time work. Family income cushioned the decline. About one-third of retirees had larger changes in income shortly before or after observed retirement transitions than right at the retirement transitions. Larger changes in income were associated with changing one's work effort. Asset income was quite variable across the entire panel. A monthly view of persons in various stages of retirement has brought into sharper focus than has previously been recognized the many paths into retirement, often over an extended period of time, during which status may change back and forth. A one-time or occasional extension of the SIPP to perhaps a 5-year period for the near-retirement-age population would increase the proportion of retirees for whom the full process is observed in such great detail. Alternatively, information on the timing of changes in labor-force and pension status may be collected in a proposed new Retirement History Study that calls for interviewing persons at 2-year intervals over a 10-year period for a more accurate picture of the retirement process.

Aged↗
PubMed1989

Income and assets of Social Security beneficiaries by type of benefit.

The SIPP data have provided a first look at the relative economic status of various types of Social Security beneficiaries. They have shown that the different types of Social Security beneficiaries face very different economic circumstances. Retired workers and wife beneficiaries have the highest family incomes adjusted for family size. Aged widows and minor children have the lowest family incomes, with high proportions of poor or near poor. And disabled workers are in between, but also have high proportions of poor or near poor. Retired-worker and wife beneficiary households also have considerably more asset holdings than disabled-worker or widow beneficiary households. Beneficiaries with high family incomes are very likely to live with relatives and to rely heavily on the relatives' income. The high-income families tend to have non-means-tested sources of family income other than Social Security amounting to substantial proportions of their total income and to have high asset holdings. Conversely, beneficiaries with low family incomes are very likely to live alone or with nonrelatives, to rely heavily on Social Security and means-tested benefits, and to have low asset holdings. A majority of ever-poor beneficiaries (with the exception of widow beneficiaries) are poor in only some months of a year. This situation is not consistent with the stereotype of beneficiaries living on fixed incomes. But the change in poverty status is often due to a change in the income of other family members rather than of the beneficiary. And in some cases, a change in poverty status occurs with little or no change in income as the cost of living rises.

Aged↗
PubMed1987

Income of retirement-aged persons in the United States.

This article reviews the composition and level of retirement income in the United States and how this has changed over time, focusing on two overlapping but distinct groups--the entire population aged 65 or older, and recent retirees. Changes in the composition of income of the aged over the past 20-30 years, including greatly expanded Social Security and pension coverage and an increasing number of persons with retirement savings, have improved the economic status of the aged not only in comparison with the aged in earlier years, but also in comparison with younger adults who derive most of their income from earnings. New retired workers are better off than the total aged population in several respects. The younger cohorts now in the labor force will spend more of their working lives in the more favorable conditions now present than was true of past new beneficiaries or the aged as a whole. It is, therefore, not unreasonable to expect that today's workers will enjoy more and larger pensions and increased income from savings to supplement their Social Security benefits when they retire.

Aged↗
PubMed1985

Economic security, 1935-85.

The economic well-being of both working and retired persons has improved significantly since the Social Security Act was passed in 1935. More people are employed now than at any time since then, despite declining employment among the aged and more years of school attendance among the young. The ratio of non-workers to workers--a broad measure of dependency--is lower now than at any time since the 1930's. Social security has grown and matured to become a strong foundation of retirement income, and other work-related employee benefits have grown in tandem with social security. Employer contributions for social insurance and related employee benefits have grown from being about a 1-percent supplement to aggregate wages and salaries in 1929 to nearly 20 percent today. Social security and Medicare account for just over a fourth of employer contributions, while other public and private retirement systems represent just over another fourth. The balance of benefits for active workers includes group health and life insurance, unemployment insurance, workers' compensation, temporary disability insurance, and related benefits. Pay for holidays, vacations, and sick leave is estimated to have increased from less than 1 percent of aggregate pay in 1929 to about 10 percent today. The improved economic status of the aged has been documented by a series of surveys beginning in 1941-42 and carried out from time to time until 1972 and biennially since 1976. The earlier surveys were supplemented with estimates from record data and tables from the Bureau of the Census. The income of the aged as a whole has grown by about 75 percent over the past 2 decades after taking inflation into account. The income of the aged as a whole grew faster than that of the nonaged in the 1970's and early 1980's when real social security benefits increased faster than inflation and wages lagged behind it. New beneficiaries in 1982 were in better health and were more likely to retire because they wanted to than was true of their counterparts in the early 1940's. Not only have benefits continued to be the main component of income of the aged as total incomes have grown, but also benefits have become much larger in relation to average earnings than used to be the case. Retired workers are much more likely now than in the early 1940's to have other pensions or income from assets to supplement benefits.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1984

Incomes of the aged and nonaged, 1950-82.

This article discusses the results of previous studies, both supportive and nonsupportive of the conclusion that the aged are as well-off as the nonaged, and then presents a range of figures from Bureau of the Census reports over the period 1950-82 that measure both the incomes of the aged and nonaged and those of subgroups within these populations. Census figures indicate that the aged and nonaged have about equal levels of average per capita family income and that about the same proportions of these groups have incomes below the poverty line. However, aged unrelated individuals, who account for about a third of all aged persons, have less than three-fifths the income of nonaged unrelated individuals. When the per capita family income of the aged is compared separately with that of families headed by persons aged 25-44 and 45-64, aged persons receive more than those under age 45 but less than those aged 45-64. Trends in the economic status of the aged and nonaged over the period 1950-82 indicate numerous fluctuations rather than a consistent improvement in the income of either group in relation to the other.

Adult↗
PubMed1983

Civil Service Retirement System annuitants and Social Security.

This article examines the extent to which annuitants of the Federal employee Civil Service Retirement System (CSRS) are entitled to Social Security benefits. It is based on linked administrative data files from the two systems. Ninety-one percent of all those receiving CSRS annuities in 1979 had worked at some point in their careers in jobs that were covered by Social Security. Almost 80 percent of the annuitants aged 65 or older were entitled to Medicare benefits. Of those aged 62 or older, 73 percent were entitled to Social Security cash benefits, including 10 percent who were entitled only as spouses or survivors of workers covered under Social Security. About 39 percent of the female annuitants aged 62 or older were entitled to benefits as wives or widows of workers, including some who were also insured for benefits based on their own earnings. The average combined benefit for those with Social Security was +845 among annuitants aged 62 or older. For those receiving only CSRS annuities, the average was +959. Those not entitled to a Social Security benefit tended to have more years of Federal service and higher annuities than did those entitled to both a Social Security benefit and a CSRS annuity.

Age Factors↗
PubMed1981

Impact on widows of proposed changes in OASI mother's benefits.

This article examines the impact of a proposal that would terminate mother's and father's benefits when the youngest child in the care of a surviving spouse reaches age 16, rather than age 18, as in current law. Losses to families and savings to the social security program are estimated by taking into account 1977 benefit receipts and provisions in the Social Security Act that would have affected benefit size in that year. The study reveals that very few widowers would have lost any income if such a provision had been in effect at that time. Two-thirds of the families headed by widows with a youngest child aged 16-17, however, would have lost some income. Sixteen percent would have had family incomes below the poverty line without mother's benefits-10 percent already below the line and 6 percent that would have fallen below it because of the change. Fewer families with children under age 16 than with youngest children aged 16-17 would have lost benefits, but more would have been in poverty. An analysis of the characteristics of widows who might use a short-term training benefit if one were made available to them suggests that such a benefit would not be used by those widows who are neediest economically and educationally.

Adolescent↗
PubMed1979

Income of the population aged 55 and older, 1976.

This article inaugurates a biennial series of reports on the income of persons aged 55 and older. The survey on which it is based updates information on the broad economic picture for a cross-section of this population and forms the basis for an analysis of trends in the financial status of the group as a whole. In 1976, persons aged 55--61 were generally working full-time, not receiving income from pensions, and married. Those aged 73 and older were predominantly not working, mostly recipients of retirement pensions, and likely to be widows. Most persons aged 65 and older were receiving social security benefits; those with neither earnings nor a second pension constituted the largest subgroup and had the lowest median income. Married couples, as a group, were substantially better off financially than nonmarried persons because they were younger, two-person rather than one-person units, and had one member who was a man. Blacks were less likely than whites to receive pension income other than social security benefits, and their median benefits and earnings were both lower.

Black or African American↗
PubMed1977

New retirees and the stability of the retirement decision.

Examination of the benefit awards data under the social security program may furnish at least partial answers to two questions: What is the estimated number retiring each year? How long do they stay retired? The calculation presented here of the number retiring in 1971 takes into account the fact that the date of the award is not necessarily the actual date of retirement. The difference has been accentuated since Medicare began and individuals have been filing for benefits solely to obtain hospital insurance protection, continuing to earn at a level that precludes receipt of benefits under the earnings test. This study of the data on payable benefits indicates that only a small proportion of retirees lose benefits because of their return to work within 3 years after award.

Age Factors↗