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Biomedical subjects

S Graham-Jones

Publications and source records attributed to S Graham-Jones.

4 recordsLinked to original sources

Mental health in the community.

Medical education needs to reflect the rapid development of community-based health care, particularly in the area of mental health. 'Mental health in the community' is a week-long collaborative course organized through the Department of General Practice at Liverpool University for first-year clinical medical students. It aims to introduce them to the range of mental health problems that exists in the community and the resources available to deal with them; to improve their counselling skills and to reduce their anxiety about mental health, both their own and other people's. The paper describes the wide variety of teaching methods and visits which are offered during the week. The course is evaluated using the method developed by Stake. Although there are some problems with student participation, 'Mental health in the community' has a significant positive overall effect on students' knowledge and anxiety levels with regard to mental health. It is making a contribution to the reorientation of medical education in Liverpool.

Anxiety

Low-frequency septal stimulation increases tyrosine hydroxylase activity in the hippocampus.

Rats were chronically implanted with recording electrodes in the dorsomedial subiculum and stimulating electrodes in the septal area. Low-frequency septal stimulation (regular inter-pulse interval = 130 msec) was used over a period of 10 days to drive the hippocampal theta rhythm at 7.7 Hz (a régime shown previously to proactively facilitate acquisition of barpressing and retard its extinction), and high frequency (77 Hz) stimulation was used to block theta rhythm (a régime shown previously to proactively retard acquisition of barpressing and facilitate its extinction). The activity of soluble tyrosine hydroxylase from hippocampus increased in animals killed 15-33 days after the end of the period of 7.7 Hz septal stimulation but not after high-frequency stimulation. Irregular low-frequency stimulation with a mean inter-pulse of 130 msec produced the same effect on tyrosine hydroxylase activity as regular 7.7 Hz theta-driving. The possible relations between the effects of low-frequency septal stimulation on hippocampal tyrosine hydroxylase and on behavior are discussed.

Animals