Biomedical subjects

S Grandis

Publications and source records attributed to S Grandis.

4 recordsLinked to original sources

PubMed1991

Evaluation of the circulating glycoprotein CA549 in mammary cancer and other malignancies.

A prospective study was carried out on a recent marker for breast cancer, CA549, a mucine-like acid glycoprotein present in the fat membranes of human milk. Fifty healthy control subjects and 91 with benign conditions, 103 mammary cancer patients and 256 patients with other types of malignancy were studied. For comparison, CEA and CA15-3 were also investigated. The CA549 cutoff was 11 U/ml. In breast cancer the marker was below the cutoff in 9 cases (92.8%); in malignancies other than breast cancer it was above the cutoff in 5 to 50% of patients. In breast cancer it was raised in 83.3% of cases (CA15-3 showed 82.9% and CEA 50%). In breast cancer after radical surgery, CA549 was normal in patients who were in TNM stage I but above the cutoff in 57.1% of those at more advanced stages. The follow-up study is ongoing among these patients. In all the study conditions, CA549 favorably compared to CA15-3 values, with sensitivity and specificity greater than CEA.

Adult↗

PubMedDate not supplied

Investing in practice: enquiry- and problem-based learning.

Enquiry-based learning (EBL) and problem-based learning (PBL) are two similar methods of educating nurses and midwives which have been recommended by the UKCC in its new report 'Fitness for Practice' (UKCC, 1999). The integration of theory and practice within the student programme is the key to bridging the theory/practice gap. The incorporation of EBL and PBL into the curriculum may help resolve this gap. As these methods of education foster learning through the use of real client scenarios it is important to stress that the partnership between clinical and academic staff is of paramount importance. This article explores EBL and PBL from the practitioner's perspective and examines some of the factors necessary for its successful implementation.

Clinical Competence↗

PubMedDate not supplied

Detection of five circulating antigens in patients with head and neck squamous cell carcinoma.

Five tumor markers (CEA, Ferritin, CA-50, TPA and SCC) were assayed in 54 patients with ear, nose and throat (ENT) cancers in early and advanced stages. The specificity of these markers always exceeded 95%. Their sensitivity ranged from 13 to 43%, and reached 72% as a combination of all five markers. No distinction was found between early and advanced stage of illness. These markers seem to have no distinct function in ENT oncological diagnosis and follow-up because objective data is easily available even in early tumors.

Aged↗

PubMedDate not supplied

[Prognostic value of tumor markers in the follow up of malignant neoplasms of the head and neck].

A group of 54 patients with previously untreated ENT malignancies were studied and findings regarding five markers generally associated with cancers (CEA, SCC, TPA, CA 50 and ferritin) are presented. The specificity of these markers always proved to be greater than 95% while their sensitivity ranged from 13% to 43%, reaching 72% as a combination of all five markers. The results obtained during follow-up on 21 randomized patients was not satisfactory due to poor sensitivity. In the opinion of the authors, the five markers assayed appear to have no distinct function in monitoring ENT cancers. The sole exception to this is SCC which presents a moderate correlation (60%) with tumor growth.

Aged↗