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Biomedical subjects

S Grossmann

Publications and source records attributed to S Grossmann.

At least 37 records · Page 2Linked to original sources
PubMed1994

Bacterial Standing Stock, Activity, and Carbon Production during Formation and Growth of Sea Ice in the Weddell Sea, Antarctica.

Bacterial response to formation and growth of sea ice was investigated during autumn in the northeastern Weddell Sea. Changes in standing stock, activity, and carbon production of bacteria were determined in successive stages of ice development. During initial ice formation, concentrations of bacterial cells, in the order of 1 x 10 to 3 x 10 liter, were not enhanced within the ice matrix. This suggests that physical enrichment of bacteria by ice crystals is not effective. Due to low concentrations of phytoplankton in the water column during freezing, incorporation of bacteria into newly formed ice via attachment to algal cells or aggregates was not recorded in this study. As soon as the ice had formed, the general metabolic activity of bacterial populations was strongly suppressed. Furthermore, the ratio of [H]leucine incorporation into proteins to [H]thymidine incorporation into DNA changed during ice growth. In thick pack ice, bacterial activity recovered and growth rates up to 0.6 day indicated actively dividing populations. However, biomass-specific utilization of organic compounds remained lower than in open water. Bacterial concentrations of up to 2.8 x 10 cells liter along with considerably enlarged cell volumes accumulated within thick pack ice, suggesting reduced mortality rates of bacteria within the small brine pores. In the course of ice development, bacterial carbon production increased from about 0.01 to 0.4 mug of C liter h. In thick ice, bacterial secondary production exceeded primary production of microalgae.

Journal Article↗
PubMed1991

[Osteonecrosis following short-term, high-dosage steroid therapy].

Osteonecrosis of the femoral head is one of many well documented side effects of long term steroid (glucocorticoid) use. Studies have reported on the skeletal effects of short term, high dose steroid therapy. This paper illustrates that short term (up to 6 weeks), high dose steroid therapy, utilized in neurotraumatology or central nervous system disease, can lead to necrosis of bone at multiple sites. This retrospective review of 6 patients supports the 18 previously reported cases: there were 5 male and one female patient, with a mean age of 32.2 years. The patients received an average dose of 5100 mg methylprednisolone for 23 days. The average interval between steroid administration and the onset of symptoms was 28 months. There was radiographic evidence of osteonecrosis of both femoral heads in all 6 patients. The female patient also had osteonecrosis of both humeral heads and both femoral condyles. Five of twelve hip joints were healed by intertrochanteric osteotomy and revascularization. One patient underwent total hip replacement. We were unable to find risk factors in these 6 patients which would make them susceptible to belated osteonecrosis of the femoral head. It is reasonable to conclude that there is a substantial risk of osteonecrosis in patients treated with high dose steroids even on a short term basis.

Adult↗
PubMed1989

[After-care in surgical replacement of the ligaments of the knee joint].

Reconstructive surgery of ligamentous injuries of the Knee Joint is often associated with a considerable impairment of its integrity and requires a high standard of surgical technique. The postoperative course, aiming towards normal function, is demanding and bound to biomechanical and biological principles. It therefore has to be built up gradually and lasts basically 12 months - with an individual variety. Up to the 6th postoperative week the healing process is in the foreground. During the second phase, up to the 12th week careful rehabilitation is aimed to improve muscle strength, increase weight bearing and optimize mobility. In the third phase, from the 12th week on, the patient regains full strength, range of motion as well as coordination, and an integrated sport rehabilitation is started.

Humans↗
PubMed1987

[Risks of cesarean hysterectomy].

From 1976 through 1984, 48 primary caesarean hysterectomies were performed in the Department of Obstetrics and Gynaecology of the Medical School of Hannover. The indications for the operation, the risk factors and the postoperative course were analysed and compared with a control group of patients with a Caesarean section. Caesarean hysterectomies had a higher incidence of excessive blood loss, blood transfusion and urinary tract injury, especially of the bladder. Based on this experience Caesarean hysterectomy should be performed if a valid indication is present. The operation cannot be recommended routinely for the purpose of sterilisation.

Adult↗