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Biomedical subjects

S Grundmann

Publications and source records attributed to S Grundmann.

10 recordsLinked to original sources
PubMed2006

[Ankyloglossia in an Anatolian Shepherd dog].

Ankyloglossia, commonknown as tongue-tie, is a rare congenital oral anomaly in dogs. A complete attachment of the lingual frenulum to the floor of the oral cavity leads to limited mobility of the tongue including problems during eating and swallowing. In humans ankyloglossia is a common anomaly in newborn infants. In our report a 5-month old Anatolian Shepherd dog was surgically treated and full function of the tongue could be achieved with a horizontal-to-vertical frenuloplasty.

Animals↗
PubMed2003

Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression.

Monocyte chemoattractant protein-1 (MCP-1) stimulates the formation of a collateral circulation on arterial occlusion. The present study served to determine whether these proarteriogenic properties of MCP-1 are preserved in hyperlipidemic apolipoprotein E-deficient (apoE-/-) mice and whether it affects the systemic development of atherosclerosis. A total of 78 apoE-/- mice were treated with local infusion of low-dose MCP-1 (1 microg/kg per week), high-dose MCP-1 (10 microg/kg per week), or PBS as a control after unilateral ligation of the femoral artery. Collateral hindlimb flow, measured with fluorescent microspheres, significantly increased on a 1-week high-dose MCP-1 treatment (PBS 22.6+/-7.2%, MCP-1 31.3+/-10.3%; P<0.05). These effects were still present 2 months after the treatment (PBS 44.3+/-4.6%, MCP-1 56.5+/-10.4%; P<0.001). The increase in collateral flow was accompanied by an increase in the number of perivascular monocytes/macrophages on MCP-1 treatment. However, systemic CD11b expression by monocytes also increased, as did monocyte adhesion at the aortic endothelium and neointimal formation (intima/media ratio, 0.097+/-0.011 [PBS] versus 0.257+/-0.022 [MCP-1]; P<0.0001). Moreover, Sudan IV staining revealed an increase in aortic atherosclerotic plaque surface (24.3+/-5.2% [PBS] versus 38.2+/-9.5% [MCP-1]; P<0.01). Finally, a significant decrease in the percentage of smooth muscle cells was found in plaques (15.0+/-5.2% [PBS] versus 5.8+/-2.3% [MCP-1]; P<0.001). In conclusion, local infusion of MCP-1 significantly increases collateral flow on femoral artery ligation in apoE-/- mice up to 2 months after the treatment. However, the local treatment did not preclude systemic effects on atherogenesis, leading to increased atherosclerotic plaque formation and changes in cellular content of plaques.

Animals↗
PubMed2003

[Traumatic rupture of the common bile duct in a dog].

Extrahepatic biliary tract rupture only rarely occur secondary to blunt or sharp trauma to the abdomen. Clinical symptoms result from chemical peritonitis and are unspecific. Recognition most often is delayed from several days to weeks, when patients suffer from ascites, icterus, dehydration and apathy. Surgical therapy depends of the site of laceration. In the present case, a dog with bile peritonitis was presented two weeks after being hit by a car. Explorative celiotomy revealed a rupture of the common bile duct. A cholecystojejunostomy was performed.

Abdominal Injuries↗
PubMed2001

Piezo-QEXAFS with fluorescence detection: fast time-resolved investigations of dilute specimens.

First X-ray absorption spectroscopy experiments with a vibrating piezo-driven double-crystal monochromator (piezo-QEXAFS) and fluorescence detection are reported. It is shown that high-quality XANES spectra can be recorded on a time scale of about 50 ms per spectrum, even for very low concentrations of < 10 mmol l-1 using fluorescence detection. The quality of the spectra, possible applications, as well as present limits of the technique will be discussed.

Metals↗
PubMed2001

[Simple techniques for the internal stabilization of fractures and luxations in the sacrococcygeal region of cats and dogs].

Two useful techniques for the repair of caudal sacral fractures and sacrococcygeal fractures/luxations are described. Pre- and postoperative clinical, neurological and radiological findings in 16 operated animals (13 cats and 3 dogs) were compared with findings in 17 (13 cats and 4 dogs) conservatively treated animals. In the surgically treated patients follow up findings were characterized by absence of hyperesthesia and a higher number of animals with recovered tail function. The authors suggest the use of these techniques in cases of caudal sacral fractures or sacrococcygeal fractures/luxations.

Animals↗
PubMed1995

[Radiologic follow-up examination of podotrochlosis].

X-rays of 205 horses having navicular disease and having been reexamined up to six times are evaluated. For this, the x-rays of each foreleg are evaluated in the dorsopalmar (Oxspring) and lateromedial view. Additionally to changes of the navicular bone, changes of the distal part of the toe are also assessed. Differences can be found in the radiographic process in view of the limitation of vascular foramina and cyst-like lesions. Vascular foramina with sclerotic rim grow less frequent than poorly defined ones and therefore allow for easier prognostication. Cyst-like lesions with sclerotic rim often stay unchanged or decrease separately, whereas poorly defined areas of rarefication show a stronger tendency to expand into the surrounding spongiosa. Changes of vascular and bone structure occur already within a few months, whereas most of the margination changes are already formed in the early stages of disease and proceed slowly. Finally the effects of the therapy are being examined for the radiographic course of disease. Following a neurectomy, a more intensive development of the changes can be observed. The rate of only minimally altered navicular bones as well as the often simultaneous occurrence of changes in the joints of the toe do not allow for a diagnosis only on the basis of radiographic findings. The often slow development of the pathological radiographic changes requires intervals of examination of at least one year and shows that prognostic statements can only be made with caution even after follow-up examinations.

Animals↗