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Biomedical subjects

S Guber

Publications and source records attributed to S Guber.

7 recordsLinked to original sources
PubMed1978

Myofibroblasts and free silicon around breast implants.

Fibrous tissue capsules, from around silicone breast implants, were examined by light microscopy, and by transmission and scanning electron microscopy, the latter combined with energy dispersive X-ray analysis. Contractile fibroblasts (myofibroblasts) were found in most of these fibrous capsules, and especially in those recently formed or manipulated. The element silicon was positively identified by X-ray analysis in half the tissue specimens. This material was found only around gel-filled implants. In the specimens studied, the clinical hardness of the breast was unrelated to the presence of silicon in the capsule.

Breast↗
PubMed1977

The life cycle of the myofibroblast.

Myofibroblasts in pig granulating wounds have an identifiable life cycle that parallels the eight week span of contraction of the wounds. As seen by electron microscopy, fibroblasts with a contractile appearance became prominent within one week after wounding and persisted for 12 weeks, after which time they were not visible. Large tangled filaments, measuring 120 Angstrom units are prominent in fibroblasts in late contracted wounds and may be actin. Such filaments could preserve fibroblasts in a contracted state and allow time for the reorganization of collagen into a fixed rigid scar.

Animals↗