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Biomedical subjects

S Guid Oei

Publications and source records attributed to S Guid Oei.

6 recordsLinked to original sources

An improved adaptive power line interference canceller for electrocardiography.

Power line interference may severely corrupt a biomedical recording. Notch filters and adaptive cancellers have been suggested to suppress this interference. We propose an improved adaptive canceller for the reduction of the fundamental power line interference component and harmonics in electrocardiogram (ECG) recordings. The method tracks. the amplitude, phase, and frequency of all the interference components for power line frequency deviations up to about 4 Hz. A comparison is made between the performance of our method, former adaptive cancellers, and a narrow and a wide notch filter in suppressing the fundamental power line interference component. For this purpose a real ECG signal is corrupted by an artificial power line interference signal. The cleaned signal after applying all methods is compared with the original ECG signal. Our improved adaptive canceller shows a signal-to-power-line-interference ratio for the fundamental component up to 30 dB higher than that produced by the other methods. Moreover, our method is also effective for the suppression of the harmonics of the power line interference.

Algorithms↗

Beat-to-beat detection of fetal heart rate: Doppler ultrasound cardiotocography compared to direct ECG cardiotocography in time and frequency domain.

In order to obtain power spectral information on the fetal heart rate in stages of pregnancy earlier than labor an algorithm has been developed to calculate the fetal heart rate on a beat-to-beat basis from Doppler ultrasound cardiotocographic signals. The algorithm was evaluated by comparing the calculated fetal heart rate with the heart rate determined from direct ECG signals measured with a scalp electrode. Heart rates were compared both in time and frequency domain. In the time domain the results achieved by both methods correlate well (correlation coefficient = 0.977 (p < 0.001)), in the frequency domain the results correlate even better (correlation coefficient = 0.991 (p < 0.001)). Based on these findings, it can be concluded that the developed algorithm provides a valuable tool for obtaining power spectral information on the fetal heart rate in stages of pregnancy earlier than labor.

Cardiotocography↗

External cephalic version: a safe procedure? A systematic review of version-related risks.

BACKGROUND: The Term Breech Trial has considerably increased the number of cesareans. External cephalic version (ECV) might be an effective method of lowering the rate of cesareans; its efficacy has been well established. However, although in the absence of anesthesia the risks are thought to be low, most studies have used populations too small to allow definite conclusions on version-related risks. METHODS: In an attempt to make an inventory of these risks, we have systematically analyzed 44 studies, covering a total of 7377 patients from 1990 to 2002. The studies used were derived from a Medline and Embase search. RESULTS: The most frequently reported complications were transient abnormal cardiotocography (CTG) patterns (5.7%). Persisting pathological CTG readings (0.37%) and vaginal bleeding occur rarely (0.47%). The incidence of placental abruption was even lower, at 0.12%. Fetomaternal transfusion was absent in five out of seven studies, with a mean incidence of 3.7%. Emergency cesareans were performed in 0.43% of all versions. Perinatal mortality was 0.16%. CONCLUSIONS: External cephalic version seems to be a safe procedure.

Breech Presentation↗

Noninvasive assessment of blood pressure variability in preterm infants.

The feasibility of measuring blood pressure (BP) variability by a noninvasive beat-to-beat finger arterial BP device (Finapres) was assessed in preterm infants. By application of the finger cuff around the infant's wrist, time and frequency domain (spectral power) analysis of noninvasive beat-to-beat BP signals were compared with intra-arterial measurements. A fast Fourier Transform was used to compute the spectral power density from 128-s periods. The low-frequency band (LF; 0.04-0.15 Hz) is partly associated with baroreflex activity. The high-frequency band (HF; 0.4-1.5 Hz) is associated with respiratory activity. In eight subjects above 1000 g, reliable signals could be obtained. We observed a high correlation between noninvasive and intra-arterial beat-to-beat systolic BP values (mean r value +/- SD, 0.87 +/- 0.11), with a gain close to 1 (mean gain +/- SD, 1.0 +/- 0.4 mm Hg/mm Hg). Finapres estimated beat-to-beat systolic BP changes more accurately than diastolic values. We found a very high amount of linear coupling, expressed as coherence function, between the power spectra of noninvasive and intra-arterial systolic BP measurements. For systolic BP, the (pooled) group mean +/- SEM coherence values were 0.93 +/- 0.00 and 0.91 +/- 0.01 for LF and HF fluctuations, respectively (NS). The wrist method of Finapres in neonates has limited value in estimating absolute BP but is useful in a clinical research situation, where identification of beat-to-beat changes in systolic BP is more important. Finapres provides a noninvasive tool for investigating autonomic cardiovascular regulation (baroreflex sensitivity, spectral analysis of BP fluctuations) in neonates.

Baroreflex↗

Cardiovascular fluctuations and transfer function analysis in stable preterm infants.

To examine the baroreceptor reflex function, a beat-to-beat analysis between systolic blood pressure (SBP) and R-R interval fluctuations was studied in 10 stable appropriate-for-gestational age preterm infants (range, 27.2-33.7 wk) in the first postnatal week during quiet sleep. Spectral power analysis, using fast Fourier transform, and transfer functions (gain and phase difference) between SBP and R-R fluctuations were estimated in a low-frequency band (LF, 0.03-0.2 Hz) and high-frequency band (HF defined as the frequency band between the 10th and 90th centiles of the individual respiratory frequency). The LF/HF ratio reflects the sympathovagal balance. The mean frequency (+/-SD) of LF peaks was centered at 0.07 +/- 0.02 Hz. The mean frequency (+/-SD) of the individual HF band was 0.82 +/- 0.21 Hz. The LF/HF ratio in the R-R interval series [median, 29; interquartile range (IQR), 16-40] was higher than in the SBP series (median, 8; IQR, 4-14). The gain between R-R interval and SBP fluctuations (median, 4.2 ms/mm Hg; IQR, 2.4-5.0) in the LF band was higher than in the HF band (median, 1.7 ms/mm Hg; IQR, 1.4-3.0). SBP fluctuations lead R-R interval fluctuations in the LF band with a median phase difference of +96 degrees (IQR, 67-132). At LF the fluctuations in SBP precede changes in R-R interval with a time delay of 3.8 s. These observations indicate a dominant role of the sympathetic system in stable preterm infants in comparison with published adult values. Cross-spectral analysis allows a test for tracking the development of the sympathetic system in neonates.

Cardiovascular Physiological Phenomena↗

Pregnant women with a low milk intake have an increased risk of developing preeclampsia.

OBJECTIVE: Several studies have suggested a relation between calcium intake and preeclampsia. In this study, we test the hypothesis that a low calcium intake by milk products increases the risk of developing preeclampsia in The Netherlands, a country where milk consumption is assumed to be high. STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991-1996. Controls were matched for age and delivery date. Data from cases and controls were obtained by questionnaire. RESULTS: The mean milk consumption per day was higher in the control group (3.0+/-0.1 units per day) than in the preeclampsia group (2.4+/-0.1 units per day, P<0.01). There was no difference in calcium intake by tablets: eight women (9.4%) with preeclampsia and seven controls (9.3%) used calcium tablets. CONCLUSIONS: This study shows an increased risk of developing preeclampsia associated with lower milk intake.

Adult↗