Biomedical subjects

S Guilhot

Publications and source records attributed to S Guilhot.

20 records · Page 2Linked to original sources

PubMed1986

On the high conservation of the human c-myc first exon.

Several hypotheses have been proposed to explain the role that the human c-myc 1st exon is thought to play in the regulation of the expression of the c-myc protein. One of these hypotheses, based on sequencing data showing an open reading frame overlapping that exon, predicts the existence of a protein most probably involved in the regulation of the expression of the c-myc protein. However, mainly because several other published sequences are devoided of such an ORF, this hypothesis did not retain much attention. In this paper, we present two additional sequences fully identical to the 1st exon region sequence we previously published, and discuss the implication of such a high degree of conservation for the human c-myc 1st exon.

Adult↗

PubMed1985

Restriction fragment length polymorphism of the human c-fms gene.

By using blot hybridization with a v-fms probe, a polymorphism for EcoRI, HindIII, and BamHI restriction endonuclease sites associated with the human c-fms locus was observed in a random adult population. This restriction fragment length polymorphism can be explained on the basis of the existence of two alleles, a and b, and is due to a short (congruent to 500 base pairs) deletion characteristic of allele a. The distribution in the analyzed population (48 unrelated individuals) is 23% heterozygotes ab, 75% homozygotes bb, and 2% homozygotes aa. Though the inheritance of this polymorphism follows a Mendelian pattern, the children from couples ab X bb are of the following genotype: 74% ab and 26% bb. These deviations from the expected frequencies of 50% suggest a selective pressure in favor of heterozygotes.

Alleles↗