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Biomedical subjects

S Gustavsson

Publications and source records attributed to S Gustavsson.

7 recordsLinked to original sources
PubMed1979

Determination of prekallikrein in plasma by means of a chromogenic tripeptide substrate for plasma kallikrein.

A method for plasma prekallikrein determination utilizing a chromogenic tripeptic substrate is presented. The method has a good reproducibility and can easily be automized. Several parameters have been optimized. By using mixtures of deficient plasmas and pooled normal plasma or purified factors it was proved that prekallikrein was the factor determined and that more than 10% (of normal plasma concentration) of FXII and HMW kininogen were essential for the activation of prekallikrein in our method. Further experiments showed that the method was fairly selective and was not influenced by inhibitors present in normal plasma. The later finding was attributed to the high dilution of plasma made possible by using a potent activator and a sensitive substrate.

Dextrans↗
PubMed1979

Plasma levels of somatostatin-like immunoreactivity-independence of kidney function.

Plasma levels of somatostatin-like immunoreactivity (SLI) and gastrin were determined by radioimmunoassay in patients with varying degrees of renal dysfunction. The plasma SLI was not increased in patients with end-stage renal failure as compared to healthy controls. In patients with varying degrees of renal insufficiency no significant correlation was found between the plasma SLI and kidney function as estimated by the 51Cr-EDTA-clearance rate. In uraemic patients a significant inverse correlation was found between plasma SLI and plasma gastrin.

Adolescent↗
PubMed1979

Transport of small bowel contents after interposition of an antiperistaltic jejunal segment in the rat.

The effect of antiperistaltic jejunal segments on small bowel transport was studied with an experimental technique permitting quantitative studies of propulsive as well as non-propulsive intestinal motility. 79 rats were provided with a permanent duodenal catheter and at the same laparotomy an anti- or isoperistaltic bowel segment based on 1, 2 or 3 mesenteric end-arcades was inserted at the midpoint of the jejunum. The evaluation of intestinal motility 1 week later indicated that an antiperistaltic segment of the rat jejunum has to be made at least 6 cm long, i.e. based on 3 mesenteric end-arcades in order to retard the propulsion of luminal contents. Not even this relatively long antiperistaltic segment was found to influence propulsion through bowel segments proximal to it, and distally the propagation velocity was accelerated. This implied that the total small bowel transit was unaffected. The non-propulsive intestinal motility, i.e. the mixing of small bowel contents was increased by the long reversed loop. The possible beneficial effect of antiperistaltic jejunal segments in short bowel syndrome and post-vagotomy diarrhoea in man may thus be attributed not to a retardation of the propulsive intestinal motility but to an increase in the non-propulsive intestinal motility.

Animals↗
PubMed1979

Gastrointestinal motility and absorption of calcium during infusion of somatostatin in the rat.

The effect of somatostatin on gastric evacuation, small bowel propulsion and gastrointestinal (GI) absorption of calcium was studied in conscious rats. Nonabsorbable 125I-PVP was deposited in the stomach or in the duodenum and the distribution of the radioactivity along the excised GI specimen was recorded after 15 min. 47Ca in chloride from was administered simultaneously and the amont of radioactivity remaining in the GI speciment at sacrifice could easily be measured. Intravenous infusion of synthetic somatostatin (50 micrograms.kg-1.h-1), which resulted in a manifest although not extreme hypersomatostatinemia had no effect either on gastric evacuation, small bowel propulsion or GI absorption of calcium. The findings do not indicate that somatostatin has a direct effect on GI motility or absorption of calcium.

Animals↗