Screening for colorectal cancer in ulcerative colitis: dubious benefits and high costs.
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Colitis, Ulcerative↗
Biomedical subjects
S Gyde
Publications and source records attributed to S Gyde.
Mortality in ulcerative colitis.
The pattern of mortality has been examined in a series of 676 patients with ulcerative colitis under long-term review to identify excesses or deficits in mortality for all causes of death in relation to the general population. The mortality risk for the whole series was 1.7 times that of the general population (p less than 0.001). Most of the excess mortality could be attributed to diseases of the digestive system. There was a heavy burden of mortality during the first year afer diagnosis and the first year after radical surgery. The significance of the excess of cancer deaths was due to the inclusion of patients who were diagnosed with cancer at first referral. In man there was a deficit of circulatory system deaths particularly those with early onset ulcerative colitis treated by panproctocolectomy after 40 yr of age. Mortality from all other causes including breast cancer showed no significant difference from that expected in the general population.
Adult↗
Mortality in ulcerative colitis: methods of analysis.
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Colitis, Ulcerative↗
Mortality in Crohn's disease.
A series of 513 patients with Crohn's disease, who were followed for 1 to more than 35 yr by one unit, experienced a twofold increased risk of dying compared with a matched group drawn from the general population (102 observed; 51.8 expected; p < 0.001). The overall risk was similar for men and women and was greatest in the younger patients within a few years of diagnosis. The relative risk of dying decreased as the age at diagnosis of their Crohn's disease increased and also fell as the period of time from diagnosis increased. There was a small but significant excess of death from tumors of the digestive organs (9 observed; 4 expected; p < 0.05). There was also a significant excess of deaths from suicide in women (3 observed; 0.4 expected; p < 0.01). The major burden of mortality lay in causes directly attributable to Crohn's disease or to associated complications within the digestive system (46 observed; 1.41 expected; p < 0.001).
Adolescent↗