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Biomedical subjects

S H Baron

Publications and source records attributed to S H Baron.

At least 19 recordsLinked to original sources
PubMed1993

Possible association of interleukin-2 treatment with depression and suicide.

Immunomodulatory agents for the treatment of certain oncologic disorders are rapidly moving from the research laboratory into clinical practice. These agents may not be void of potential neuropsychiatric sequelae. The following clinical report concerns a previously nondepressed patient with no history of psychiatric disorders who became depressed and killed himself while being treated with interleukin-2. It is important that consulting psychiatrists be sensitive to acute emotional changes in cancer patients taking immunomodulatory agents.

Depression↗
PubMed1982

Effect of prostaglandin inhibition on the prolactin, renin, and aldosterone responses to dopamine antagonism.

The possible interactions between the prostaglandin and dopamine systems in the control of prolactin, renin and aldosterone secretion were studied in seven normal subjects. The responses to the dopamine antagonist, metoclopramide (10 mg. i.v.) were studied before and after prostaglandin inhibition with indomethacin (50 mg every 8 hr for 3 doses) while the subjects were in balance on a low sodium (less than 10 meq/day) diet. Urinary prostaglandin E excretion was reduced 61% (p less than 0.05) with indomethacin administration. Plasma renin activity (active and inactive) was not significantly affected by indomethacin treatment. However, the renin activity following metoclopramide tended to rise before, and fall after, indomethacin. Plasma aldosterone increased rapidly after metoclopramide, peaking at ten to fifteen minutes (p less than 0.01). There was no significant difference between the control and indomethacin days. Prolactin increased following metoclopramide, peaking at fifteen to thirty minutes (p less than 0.01). The prolactin response was significantly (p less than 0.05) decreased by indomethacin at four of six time points and the area beneath the response curve was significantly (p less than 0.05) blunted (3048 +/- 132 versus 3882 +/- 146 ng. min/ml). The results suggest that a cyclooxygenase product may modulate the prolactin response to dopamine antagonism. Although the renin response to metoclopramide was altered by indomethacin, the aldosterone response to dopamine antagonism is not medicated by cyclooxygenase products or the renin-angiotension system.

Adult↗
PubMed1979

Brain radiation necrosis following treatment of an esthesioneuroblastoma (olfactory neurocytoma).

Esthesioneuroblastoma is an uncommon malignant nasal tumor which may be difficult to diagnose. Once diagnosed, selection of treatment may be a dilemma. Some advocate preoperative radiation and surgery; others, surgery and postoperative radiation if needed. A case that developed brain necrosis from postoperative radiation is presented. It is felt that the possibility exists that the patient might still be living with tumor had irradiation not been given. This is a plea for the conservative approach to treatment. The author agrees with John S. Lewis that it is unwise to use all modalities at once as there is no definite evidence that any one method of treatment or a combination of surgery and irradiation will alter the prognosis. The paper stresses the brain hazards of irradiation.

Adult↗
PubMed1978

Aspirin stimulates insulin and glucagon secretion and increases glucose tolerance in normal and diabetic subjects.

Normal subjects and patients with adult-onset diabetes received 10 gm. of aspirin in four days. On the fourth day, the fasting serum glucose and the glucose response to oral glucose were decreased in both groups. These changes were associated with increased levels of serum insulin and pancreatic glucagon, although the glucagon responses to oral glucose were unchanged. In the diabetic patients, aspirin therapy was followed by a decreased glucose response to I.V. glucose and by the appearance of an early insulin peak, which could not be demonstrated before treatment. Aspirin did not affect the I.V. glucose tolerance in normal subjects, although it did enhance the early insulin peak. A decrease in the fasting levels of free fatty acids was noted in both groups, whereas the fasting level of triglycerides decreased only in the diabetic patients. Cholesterolemia did not change in either group. A few preliminary observations indicate that, in normal subjects, ibuprofen and ketoprofen, two other presumed prostaglandin inhibitors, did not affect fasting glycemia, glucose tolerance, or the insulin response to glucose. No changes were noted after the administration of placebo.

Adult↗
PubMed1975

Rerouting the external auditory canal. A method of correcting congenital stenosis.

An hourglass or funnel-shaped, stenosed, external auditory meatus with a normal tympanic membrane, middle and inner ear is one of the congenital anomalies that occasionally occurs. Such abnormality was present in both ears of a woman and caused chromic otitis externa and deafness. A routine meatoplasty on the right ear failed because of an unusual cephalad position of the drumhead in relation to a "downhill" position of the stenosed outer meatus. Rerouting the ear canal to a horizontal position by removing bone of the canal superiorly, posteriorly, and inferiorly, and grafting the now horizontal canal with skin taken from the postauricular fold produced a good result. This is a satisfactory procedure for a woman, but would be cosmetically unacceptable for a man.

Adolescent↗