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S H Hartzen

Publications and source records attributed to S H Hartzen.

25 records · Page 2Linked to original sources
PubMed1986

A, B, H antigen expression in transitional cell carcinomas of the urinary bladder.

The prognostic value of A, B, H blood group antigen determination in superficial bladder cancer is unclear. Recent immunohistochemical studies employing monoclonal antibodies and Ulex Europaeus Agglutinin I (UEA-I) (Vector) have shown that A, B, H detectability and distribution in non-neoplastic urothelium are influenced by methodologic factors and, most importantly, by the secretor status. The authors investigated the A, B, H antigen in 93 tumors of the urinary bladder (78 secretors, 15 nonsecretors) and semiquantified the alterations from the expected normal expression on a scale from 0 to 3. Four O saliva nonsecretors as expected showed no staining and were excluded. Eighty tumors showed abnormal A, B, H expression and in 37 of these, A, B, H antigens were not detected. Tumors of A and O individuals showed statistically different reactivities, probably related to differences in the specificity of the employed A- and H-reagents. A, B, H expression was influenced by stage and grade (P less than 0.05, P less than 0.10) and was correlated to the clinical course of A but not O patients. These results, suggesting that alterations in the A, B, H expression occur early in the neoplastic development and follow the synthetic pathways in an opposite direction, emphasize that reagents recognizing blood group precursor substances, common to all individuals irrespective of the ABO and saliva secretor types, may increase the prognostic accuracy of blood group antigen determination in bladder cancer.

ABO Blood-Group System↗
PubMed1986

Relationship between penicillinase production and the in-vitro activity of methicillin, oxacillin, cloxacillin, dicloxacillin, flucloxacillin, and cephalothin against strains of Staphylococcus aureus of different phage patterns and penicillinase activity.

A total of 157 strains of Staphylococcus aureus of different phage patterns and penicillinase production were investigated for their susceptibility to methicillin, oxacillin, cloxacillin, dicloxacillin, flucloxacillin and cephalothin by an agar dilution method. Only strains of the 52, 52A, 80, 81 complex had significantly higher IC-50 values than the rest of the strains. No correlation was found between penicillinase production and the IC-50 values. Penicillinase susceptibility divided the antibiotics into two groups: one including methicillin, oxacillin and cephalothin, and the other included dicloxacillin, cloxacillin and flucloxacillin. Nineteen strains of S. aureus which existed in both a penicillinase producing and a penicillinase non-producing form were examined for susceptibility to the six antibiotics. The difference between penicillinase positive and penicillinase negative variants was especially marked for flucloxacillin and cephalothin. Methicillin induction prior to susceptibility testing had only a minor influence on the results. Investigation of the stability of methicillin and the four isoxazolyl penicillins against penicillinase production by 37 strains of S. aureus showed methicillin to be the most stable antibiotic. This was followed by dicloxacillin, cloxacillin, flucloxacillin, and oxacillin in that order. The order of stability was identical and independent of phage pattern and quantitative penicillinase production.

Bacteriophage Typing↗
PubMed1986

Value of clinical decision on antibiotic treatment of fever episodes following transurethral resection of the prostate.

The value of clinical decision on antibiotic treatment of fever episodes following transurethral resection of the prostate was assessed in 134 patients. Besides bacteriuria, need of blood transfusions and various catheter problems were associated with a significant number of fever episodes. The majority of patients with fever not given antibiotic therapy had negative urine cultures (90%), whereas 41% of the patients with fever treated with antibiotics showed negative urine cultures indicating an overtreatment of these patients. Out of the total number of patients, only 10% with subsequent negative urine cultures received antibiotics, a figure which should be compared to the inevitable rate of overtreatment when general antibiotic prophylaxis is preferred.

Aged↗
PubMed1985

In-vitro activity of methicillin against clinical isolates of Staphylococcus aureus.

Methicillin activity against 149 penicillin-resistant, methicillin-susceptible Staphylococcus aureus strains from bacteraemia cases with endocarditis (n = 89) or without endocarditis (n = 60), from the years 1976-1981, was studied with broth dilution and agar dilution. While no differences in methicillin susceptibility were found in relation to the origin of the strains, Staph. aureus of the phage type complex 94,96 showed significantly higher MIC and IC50 by agar dilution than strains of other phage groups/complexes. This difference probably has no clinical importance but is of epidemiological interest. Broth dilution MIC was generally one dilution higher than agar dilution MIC, possibly explained by methodological factors. The MBC/MIC ratios never exceeded two in any of the strains, indicating a lack of tolerance in these clinically important isolates.

Bacteriophage Typing↗
PubMed1985

The determination of specific IgA-antibodies to Yersinia enterocolitica and their role in enteric infections and their complications.

Specific serum IgA-antibodies, mainly produced in the lymphoid tissue of the gastrointestinal tract (GALT) might exhibit some special characteristics deviating from IgM- and IgG-antibodies: they do not agglutinate nor fix complement. They cannot be determined by usual routine antibody techniques; indirect methods must be used. An antiglobulin-assay was used in an extensive investigation over a two-year period on sera from 8,445 patients to determine IgA-antibodies specific to Yersinia enterocolitica, serotype 3. Y. enterocolitica agglutinins were found in 965 patients, 508 of them with significant titres of greater than or equal to 80. 347 of the 2,111 patients with low titres (10 to 40) had a significantly elevated amount of IgA antibodies. The diagnoses of the IgA-positive patients fell into three groups: acute infections, acute reactive complicatory inflammations, mainly arthritis, chronic inflammatory connective tissue diseases. The IgA-antibody pattern was: In early samples from patients with acute enteric infections they might be the only antibodies present following, largely, during the course of the disease the agglutinating IgM and IgG antibodies, except in patients with long-lasting or chronic complications where IgA antibodies were elevated. It is concluded that determination of specific antibodies of IgA class in cases of Y. enterocolitica infections is an important diagnostic test and, moreover, of prognostic value in the evaluation of chronicity.

Adolescent↗