Biomedical subjects
Publications and source records attributed to S H Houston.
HIV therapy has advanced greatly in the past couple of decades. Along with advances in treatment have come new adverse effects associated with therapy. We present a case of Toxoplasma encephalitis following initiation of HAART consistent with the emerging syndrome known as immune restoration disease.
Primary cutaneous aspergillosis is an uncommon entity that may occur in immunosuppressed hosts, usually resulting from contact with contaminated medical devices used in patient care. The infection spreads locally with subsequent skin necrosis due to angioinvasion and thrombosis. We report primary cutaneous aspergillosis following contact with contaminated gauze, and we review the relevant literature.
Pneumonia is a common and potentially fatal complication of transplantation. The clinical approach to this problem requires a multipronged attack. Thorough evaluation of the donor and recipient reduces the risk of infection while pointing to likely infectious complications to be anticipated posttransplant. Careful attention to infection control measures with emphasis on handwashing, high efficiency particulate air filtration, and aggressive outbreak investigation minimizes nosocomial pneumonias. Appropriate use of vaccines and prophylactic antimicrobial therapies decreases posttransplant morbidity and mortality. Once pneumonia occurs, a rapid, thorough diagnostic evaluation increases the likelihood of survival for the individual patient and focuses attention on environmental risks that may pose a hazard to the other transplant recipients in the clinician's institution.
The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.
Linguistic concepts of the principles and rule systems composing language are instantiated in the models known as grammars. These grammars, typically generative in format, are descriptions of those representatives of universal rule processes found in the particular language being described. Many psycholinguists are now becoming concerned with how to determine to what extent such formal descriptive language models also embody psychologically valid descriptions of speaker processes. It is this issue to which the current article is addressed. The psycholinguistic validity of a language model may be studied by experimental investigation of the degree to which speaker behaviors follow the patterns dictated by linguistic theory. In this article, English phonology, specifically the nature of phonological units in internalized phonological representations, was chosen as the area for study. The choice was made because English phonology is particularly well described by the standard theory, and because this theory contains explicit predictions about how English speakers' phonological knowledge will be realized in their control of English orthography, e.g., in spelling. The present article discusses a series of studies designed to determine whether speakers' spelling behavior follows the supposed patterns of phonological competence, wherein any divergences may lie, and to what processes they may be attributed. The results of the studies suggest the necessity for differentiating a formal description of English phonology from a psycholinguistic model.
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