The diagnostic value of cytophotometry in malignant pleural effusions.
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Biomedical subjects
Publications and source records attributed to S H Kuo.
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Twenty-five patients, each of whom had peripheral intrathoracic lesions that were smaller than 5.0 X 5.0 cm in size and not diagnosed by conventional methods, underwent real-time sonography and ultrasonically guided aspiration biopsy. The lesions included 18 nodules, two infiltrates, and five cavitary lesions. Sonography showed homogeneous hypoechoic or isoechoic density with well-defined margins in 16 of the nodules, and heterogeneous echogenicity with irregular margins in infiltrates. The cavitary lesions showed a hyperechoic ring with a central sonolucent area. Biopsy specimens were successfully obtained by percutaneous aspiration under ultrasound guidance in 24 (96%) of the patients, and a positive diagnosis was established in 21 (84%) by cytology and/or histology. All 17 malignant lesions were diagnosed by aspiration biopsy, while only four of seven benign lesions were diagnosed by this method. Two patients (8%) experienced minimal pneumothorax after aspiration biopsy. We conclude that real-time sonography, including ultrasonically guided aspiration biopsy, is a useful and safe method for examination of peripheral intrathoracic lesions and has a high diagnostic yield.
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In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics and demographic data for Taiwan after 1932; (2) data reported by WHO for international comparison; (3) prevalence surveys carried out in 1972-73 and 1977-78; and (4) 7,307 clinical cases collected from major hospitals since 1952. Some possible factors, i.e., the smoking history of patients, yearly tobacco consumption, geographical distribution of patients, and the number of motor vehicles were studied in correlation with epidemiological characteristics. We have found that the mortality of lung cancer in Taiwan has been increasing rapidly for both sexes. The rate of increase is probably the highest in the world. The prevalence rate increased from 15.26 per 100,000 population in 1972-73 to 22.35 in 1977-78. The male to female ratio has remained unchanged, roughly at 2:1, over the past 50 years. Adenocarcinoma contributed to about 60% of lung cancer in women and 35% in men. This proportion has not changed during the past 30 years. The cancer showed a striking urban predominance. The causes of the rapid increase in lung cancer in Taiwan cannot be explained solely by tobacco smoking, particularly for women, although it certainly plays an important role.
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