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Biomedical subjects

S H Ling

Publications and source records attributed to S H Ling.

6 recordsLinked to original sources
PubMed2005

An improved genetic algorithm based fuzzy-tuned neural network.

This paper presents a fuzzy-tuned neural network, which is trained by an improved genetic algorithm (GA). The fuzzy-tuned neural network consists of a neural-fuzzy network and a modified neural network. In the modified neural network, a neuron model with two activation functions is used so that the degree of freedom of the network function can be increased. The neural-fuzzy network governs some of the parameters of the neuron model. It will be shown that the performance of the proposed fuzzy-tuned neural network is better than that of the traditional neural network with a similar number of parameters. An improved GA is proposed to train the parameters of the proposed network. Sets of improved genetic operations are presented. The performance of the improved GA will be shown to be better than that of the traditional GA. Some application examples are given to illustrate the merits of the proposed neural network and the improved GA.

Algorithms↗
PubMed2001

Green fluorescent protein-tagged Edwardsiella tarda reveals portal of entry in fish.

The application of green fluorescent protein (GFP) to identify the portal(s) of entry of bacterial pathogens in animal hosts was studied using the fish pathogen Edwardsiella tarda and blue gourami, Trichogaster trichopterus. An immersion challenge model was utilized to mimic natural infection conditions in fish. Gastrointestinal tract, gills and the body surface of fish were found to be the sites of entry of virulent E. tarda (PPD130/91) by histological and infection kinetics studies. On the other hand, avirulent E. tarda (PPD125/87) was mainly found in the gastrointestinal tract, and the bacterial population in tissue declined over a period of 7 days.

Animals↗
PubMed1994

[A new morphological classification of urinary erythrocytes for evaluating the source of hematuria].

For differentiation of glomerular from urological hematuria more accurately, a new morphological classification of urinary erythrocytes was studied in 74 cases of glomerular and 58 cases of urological hematuria. For each urine sample, 100 urinary erythrocytes were observed with phase-contrast microscopy and classified into 5 "glomerular" shapes (G1-G5), 5 "urological" shapes (N1-N5) and an unclassified shape. The result was that occurrence of G1, G2, G3, G4, G5 or unclassified shape group appeared significantly (P < 0.01) higher in glomerular diseases than in urological diseases, and among them G1 was the most specific shape for glomerular hematuria. Using percentage of sigma G (G1 + G2 + G3 + G4 + G5) and setting the cut-off at 20%, the sensitivity and specificity for the diagnosis of glomerular diseases were 95.9%. When percentage of G1 (doughnut-like cell with one or more blebs) was used at a cut-off of 1%, sensitivity and specificity were 75.7% and 96.5% respectively. These results were more satisfactory as compared with those in most of the previous reports. Moreover, this new classification is more objective, accurate and clear.

Adolescent↗
PubMed1993

[Urine levels of soluble interleukin 2 receptor and free light chain immunoglobulins in lupus nephritis].

To find out the relationship between soluble interleukin 2 receptor (sIL-2R) or free light chain immunoglobulins (FLCI) and the activity of lupus nephritis (LN), we determined sIL-2R by ELISA and FLCI by immunodiffusion in the urine of 30 patients with LN and 20 normal persons. We also studied the correlation of sIL-2R levels with clinical and serologic findings over 3 months in the patients. sIL-2R was significantly higher in the active LN patients (160 +/- 108U/ml) than in the normal controls (85 +/- 19U/ml, P < 0.01) and in the inactive LN patients (92 +/- 23 U/ml, P < 0.05), but their serum complements did not change significantly. The positive rate of urine FLCI was higher in the active LN patients than in the inactive LN patients (77% to 15%, P < 0.01) and the normal controls (negative). These results suggest that the urine sIL-2R and FLCI are sensitive markers for disease activity in LN.

Adolescent↗