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Biomedical subjects

S H Morgan

Publications and source records attributed to S H Morgan.

53 records · Page 3Linked to original sources
PubMed1985

Thrombocytopenia in SLE and related autoimmune disorders: association with anticardiolipin antibody.

Anticardiolipin antibody levels were determined in 116 patients with systemic lupus erythematosus and related autoimmune disorders. Forty-three of these patients had a history of thrombocytopenia--36 of whom had SLE, three primary Sjögren's syndrome, two rheumatoid arthritis and two mixed connective tissue disease. IgG anticardiolipin antibody levels were raised in 31 (72%) of the 43 patients and IgM anticardiolipin antibody levels were raised in 19 (44%). There was a strong statistical correlation between thrombocytopenia and raised anticardiolipin antibody levels of both the IgG (P less than 0.001) and IgM (P less than 0.01) immunoglobulin classes. Of the 20 patients with the highest IgG anticardiolipin antibody levels 16 had a history of thrombocytopenia. We suggest that anticardiolipin antibodies may play a direct role in mediating platelet destruction in autoimmune disorders.

Antibodies↗
PubMed1985

Anticardiolipin antibodies in autoimmune thrombocytopenic purpura.

Using a recently devised solid phase radioimmunoassay to detect anticardiolipin antibodies, we report the presence of these antibodies in 30 of 96 patients with chronic autoimmune thrombocytopenic purpura (AITP). IgG anticardiolipin antibody levels were elevated in 14 patients and IgM anticardiolipin antibody levels were elevated in 27 patients. We suggest that these antibodies may mediate peripheral platelet destruction by binding to phospholipids in the platelet membrane. It is also conceivable that the presence of anticardiolipin antibodies may select a subpopulation of patients with chronic AITP who may go on to develop other autoimmune disorders, such as systemic lupus erythematosus.

Antibodies↗
PubMed1985

Fluid removal by haemofiltration in diuretic resistant cardiac failure.

A 60 year old woman with diuretic resistant cardiac failure was treated with intermittent haemofiltration before tricuspid valve replacement. This technique can remove large quantities of fluid rapidly, thus controlling oedema and allow appropriate fluid replacement. Haemofiltration is thus a simple and safe method of managing unresponsive oedema in cardiac failure sometimes allowing corrective cardiac surgery.

Blood↗
PubMed1985

Rheumatoid arthritis and pulmonary hypertension. A report of three cases.

Three women with well established rheumatoid arthritis (RA) who developed pulmonary hypertension during the course of their disease are reported. In one patient there was mild pulmonary fibrosis but this appeared unrelated to the severity of the pulmonary hypertension. Another patient had increased platelet stickiness which may have contributed to this complication, whereas in the third patient, no contributing factors were apparent. The pulmonary complications of RA and their relationship to the development of pulmonary hypertension are discussed.

Adult↗
PubMed1984

Anti-Jo-1 antibody: a marker for myositis with interstitial lung disease.

An autoantibody known as anti-Jo-1 antibody is found in 25% of patients with myositis. Its prevalence in patients with both myositis and cryptogenic fibrosing alveolitis was 68% (13 out of 19 patients), compared with 7.5% in patients with myositis alone (four of 53) and 3% in patients with cryptogenic fibrosing alveolitis alone (two of 62). Anti-Jo-1 antibody may be useful in indicating patients with myositis and cryptogenic fibrosing alveolitis. Raynaud's phenomenon, the sicca syndrome, and mild arthritis are also often part of the syndrome.

Autoantibodies↗
PubMed1984

Distal aortitis complicating Reiter's syndrome.

Distal aortitis was diagnosed in a 44 year old man who had previously shown clinical features of Reiter's syndrome. This appears to be the first reported case of distal aortitis associated with Reiter's syndrome.

Adult↗
PubMed1984

Neuro-otologic applications of simultaneous multi-channel auditory evoked response recordings.

Multichannel auditory brain stem response (ABR) recordings were obtained in 75 acute, severely brain injured patients. The purpose of the study was to assess, in patients with varied neuro-otologic pathology, the clinical feasibility and value of measuring the ABR simultaneously with more than one electrode array. The use of alternative electrode arrays, in addition to the conventional (vertex to stimulus ipsilateral ear) array, augmented confident identification of wave components I through VI, and was particularly useful in patients with marked middle ear pathology which confounded ABR interpretation. The ABR recorded with an indifferent (noncephalic) reference electrode, e.g., was characterized by increased Wave V amplitude, and improved definition of Wave IV vs. V. Case studies are presented to illustrate neuro-otologic applications of the multichannel recording technique.

Adolescent↗
PubMed1984

A double-blind study comparing sodium aurothiomalate and auranofin in patients with rheumatoid arthritis previously stabilized on sodium aurothiomalate.

Auranofin, an orally active gold preparation, was compared with sodium aurothiomalate in a double-blind trial in patients with rheumatoid arthritis fulfilling the ARA criteria, who had been stabilized on sodium aurothiomalate for at least six months. Twenty-four patients have so far been entered in the trial, of whom fourteen have been randomly allocated to receive auranofin and ten to receive sodium aurothiomalate. After initial stabilization, patients receive either auranofin 6 mg daily and placebo injection, or sodium aurothiomalate 50 mg monthly and placebo tablets. Five patients have completed one year on auranofin. The remaining nine patients were withdrawn because of loss of efficacy (two), side-effects, (five), loss of efficacy and side-effects (one) and default (one). Four patients have completed one year's treatment with sodium aurothiomalate. Of the remaining six patients, two were withdrawn because of side-effects, three because of poor disease control and one because of side-effects and poor disease control. Diarrhoea occurred in eight patients receiving auranofin. Rashes occurred in both groups but otherwise there were no serious side-effects. The efficacy of both drugs appeared similar, there being no significant differences in morning stiffness, fatiguability, visual analogue pain score, grip strength and articular index. There were also no significant differences in laboratory parameters of efficacy. Auranofin appears to control disease activity in rheumatoid arthritis but diarrhoea is a frequent side-effect.

Adolescent↗