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Biomedical subjects

S H Nissen

Publications and source records attributed to S H Nissen.

6 recordsLinked to original sources

Ant-egg cataract. An electron microscopic study.

The ultrastructure of the ant-egg cataractous lens has been studied. Comparison of tissue demineralized by means of EDTA with untreated tissue showed the calcium salts in the ant-eggs to be mostly crystalline. A laminar appearance of the ant-egg seen in EDTA treated material suggested an intermittent growth of the structure. In the ant-eggs, as well as in some areas separate from these, membrane limited cytoplasmic bodies could be seen in many cases, the membranes of which were partly joint and partly separated by an electron dense material. It is suggested that the calcifications seen as the ant-eggs are secondary phenomena to an abnormal metabolism, morphologically seen as membrane limited cytoplasmic bodies.

Cataract

Ant-egg cataract. A study of a family with dominantly inherited congenital (ant-egg) cataract, including a histological examination of the formed elements.

A family with "ant-egg" cataract in three generations is described. The cataract is congenital, probably of autosomal dominant inheritance. Light microscopy of the ant-eggs showed that they are made up of a peripheral zone of lens material and a large almost homogenous centre. Element analysis by X-ray spectrophotometry showed a high content of calcium and phosphorus in the centre. The cataract has been easy to operate on and the postoperative visual results have been good.

Calcium

Acetazolamide in the treatment of haemorrhagic glaucoma.

For the first time the clinical effect of acetazolamide (AZA) in haemorrhagic glaucoma has been the subject of a controlled study. The clinical impression of none, or a slight effect of AZA in haemorrhagic glaucoma was confirmed. An intravenous injection of a AZA, 10 mg/kg body weight, produced in 13 patients (14 eyes) with haemorrhagic glaucoma a fall in the intraocular pressure (IOP) of only 7.7% within 30 min. A similar examination of 4 patients (5 eyes) with other types of glaucoma showed a drop in pressure of 32.0%. Examinations of the haemorrhagic-glaucoma eyes later that day and on the next day showed no further effect of AZA on the IOP. It is concluded that AZA is of no importance in the treatmen of haemorrhagic glaucoma.

Acetazolamide