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Biomedical subjects

S H Norris

Publications and source records attributed to S H Norris.

At least 19 recordsLinked to original sources
PubMed1991

A competitive ELISA for the anti-intercellular adhesion molecule-1 (anti-ICAM-1) binding activity of monoclonal antibody R6.5 in serum.

A competitive ELISA was developed to measure serum concentrations of immunoreactive R6.5, a mouse IgG2a monoclonal antibody which binds to and inhibits the interactions of human intercellular adhesion molecule-1 with glycoproteins of the CD18 complex and with rhinoviruses. The assay design permitted quantitative measurement of the functional activity of the antibody in serum. The working range of the assay was from 2.15 to 215 ng ml-1, and intra-assay and inter-assay relative standard deviations averaged 13 and 20%, respectively. Serum caused interferences with the assay when spiked in vitro, but authentic serum samples obtained from intravenously dosed animals did not exhibit these interferences. Characteristics of the assay, as well as results of a pharmacokinetic study in rabbits, are presented.

Animals↗
PubMed1990

Quiz of the month.

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Diabetic Nephropathies↗
PubMed1990

Renal eicosanoids.

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Arginine Vasopressin↗
PubMed1989

Fatal hepatic necrosis caused by disseminated type 5 adenovirus infection in a renal transplant recipient.

This is an unusual case of fatal hepatic necrosis caused by disseminated type 5 adenovirus in a renal transplant recipient. This adult patient may have been colonized at the time of transplantation with a kidney from a pediatric donor. The adenovirus became invasive when the host's cellular immune system was suppressed by high doses of corticosteroids given to reverse acute allograft rejection.

Adenoviridae Infections↗
PubMed1989

Quiz of the month.

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Acid-Base Imbalance↗
PubMed1989

The blood supply of the calcaneal tendon.

The microvascular anatomy of the calcaneal tendon was investigated in cadaver tendons by injection of barium sulphate and indian ink and a quantitative study of intratendinous blood supply was made, using a computer-assisted image analysis system. There was a reduction in both the number and the mean relative area of vessels in the mid-section of the tendon. This area of reduced vascularity may be of significance in the pathogenesis of rupture.

Achilles Tendon↗
PubMed1988

Recovery following fractures of the clavicle treated conservatively.

A consecutive series of 140 patients with fractures of the clavicle were reviewed a minimum of 3 months after their injury. All had been treated conservatively using either a figure-of-eight bandage or broad arm sling. No statistical difference was found in the speed of recovery P greater than 0.05 when these two methods of treatment were compared in patients matched for sex and age. The patient's age at the time of the injury, however, did affect recovery with 33 per cent of those over the age of 20 years still having symptoms 3 months after they had sustained their fracture. Although lateral third fractures occurred more commonly in this age group than in the younger patients, the site of fracture did not adversely affect the speed of recovery P greater than 0.05.

Adolescent↗
PubMed1988

Mallet finger: a trial of two splints.

Over a period of twelve months, 116 cases of mallet finger were allocated randomly to treatment with either a Stack or Abouna splint. The two splints were equally effective, producing a cure or a significant improvement in approximately 50% of cases. However, the Stack splint was much preferred by the patients, who found it more comfortable, more robust and easier to keep clean.

Adult↗
PubMed1988

The microvascular anatomy of the distal digital extensor tendon.

The circulation of six hands from four human cadavers was washed out, the hand then being injected with contrast material to provide 24 fingers for analysis under the dissecting and light microscopes. The microvascular anatomy of the distal part of the extensor tendon was outlined and is described, with particular emphasis on the fine vessels within the tendon and on the tendon surface. An area of deficient blood supply was shown within the tendon which may have implications in the aetiology and treatment of mallet finger.

Cadaver↗
PubMed1988

The mechanism of clavicular fracture. A clinical and biomechanical analysis.

A consecutive series of 150 patients with clavicular fractures is presented. In 81% detailed information regarding the mechanism of the injury was available and, of these, 94% had fractured their clavicle from a direct blow on the shoulder; only 6% had fallen on the outstretched hand. This finding, at variance with commonly held views regarding the mechanism of this injury, was further investigated by biomechanical analysis of the forces involved in clavicular fractures. The biomechanical model supported the clinical findings.

Biomechanical Phenomena↗