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Biomedical subjects

S H Pearce

Publications and source records attributed to S H Pearce.

43 records · Page 3Linked to original sources
PubMed1991

Chronic hypernatremia due to impaired osmoregulated thirst and vasopressin secretion.

We report the case of a young man who became adipsic following a subarachnoid hemorrhage and subsequently had two episodes of life-threatening hypernatremia. Investigations demonstrated that he had defective osmoregulated thirst and AVP release, but normal AVP responses to hypotension and nausea. There is also evidence that he had intact baroregulated thirst. We discuss the results of our investigations in the context of current models of hypothalamic-neurohypophysial function.

Adult↗
PubMedDate not supplied

Horner's syndrome: an unusual iatrogenic complication of pneumothorax.

A patient is reported with spontaneous pneumothorax in whom a Horner's syndrome occurred as a complication of drainage tube thoracostomy. Ascending sympathetic fibres lie in close contact with the parietal pleura at the apex of the hemithorax and may be damaged by an inappropriately positioned thoracostomy tube. It is suggested that drainage tubes found to be sited medially at the apex of the hemithorax should be immediately repositioned to avoid this complication.

Adult↗
PubMedDate not supplied

Calcium homeostasis and disorders of the calcium-sensing receptor.

The identification of the CaR has cast light on many aspects of normal extracellular calcium homeostasis, particularly in relation to the regulation of PTH and calcitonin secretion and renal calcium reabsorption. In addition, loss and gain of function CaR mutations have provided an insight into the pathogenesis of the clinical syndromes of FBHH, NSHPT and ADHH. Careful attention to the urinary calcium excretion, together with other investigations, should enable the physician to distinguish these disorders of calcium sensing from other causes of hypercalcaemia and hypocalcaemia.

Animals↗