PubMed Health⌕ Search

Biomedical subjects

S H Wang

Publications and source records attributed to S H Wang.

At least 19 recordsLinked to original sources
PubMed1992

[Intravesical BCG, mitomycin-C and thiotepa in the prevention of bladder tumor recurrence after operation].

We observed the effects of intravesical irrigation with BCG (group B), Mitomycin-C (group M), and Thiotepa (group T) in prophylaxis of bladder tumor recurrence after surgical treatment. Follow-up for 1-10 years showed that the recurrence rate of bladder tumor was 12.5% (3/24) in group B, 46.9% (15/33) in group M, and 61.8% (21/34) in group T respectively. The effect of BCG was far better than that Mitomycin-C and Thiotepa (P < 0.01). In 5 cases, who failed to Thiotepa, also showed satisfactory results after use of intravesical BCG. Considering the side-effects of intravesical BCG, Thiotepa or Mitomycin-C should be used as the first choice of drugs in preventing the tumor recurrence.

Administration, Intravesical↗
PubMed1992

[Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. I. Clinical and parasitological observations].

We compared the efficacy of a single dose of ivermectin with that of a standard course of deithylcarbamazine (DEC) for the control of microfilaremia in 60 patients with banrroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with DEC. The study was done as a randomized, double-blind trial. Complete, but transient clearance of microfilaremia was observed in both treatment groups. One year later, recurrent microfilaremia was present in 7 patients treated with ivermectin and in 5 treated with DEC. Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremia. Side effects of either treatment were common but mild. Febrile reactions were more frequent in the ivermectin group: while localized reactions consistent with a flare up of acute filarial disease occurred mostly in the DEC group. We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.

Adolescent↗
PubMed1992

Spectral analysis of bubble sounds in decompressed guinea pigs.

Doppler ultrasonic monitoring was used to detect bubbles in sixteen guinea pigs subjected to a simulated air-dive profile of 9 ATA for 25 minutes. After completion of the decompression, eight subjects did not demonstrate any signs of decompression sickness (DCS), two developed paraplegia and six died. Under sedation, the Doppler ultrasonic bubble detector was placed precordially to record the bubble signals in both pre-dive and post-dive. The recorded signals were analyzed with a high resolution signal analyzer to compare changes between pre-dive and post-dive spectrograms. Bubble signals appeared in the frequency range between 0.64 +/- 0.02 KHz and 6.08 +/- 0.30 KHz. In terms of the net spectral level versus frequency areas (difference between pre-dive and post-dive spectrograms), the mean areas in the paraplegia group and the death group were significantly larger than those in the group without DCS. Therefore, we concluded that the spectral analysis may be an objective and quantitative adjunctive method to the interpretation of Doppler bubble signals.

Animals↗
PubMed1992

[Ultrastructure of erythrocytic stage of Plasmodium vivax in humans].

After the merozoite entered the erythrocyte, the membrane debris in the parasitophorous vacuoles of early ring form was passed out through a narrow external aperture in erythrocyte to the exterior. The trophozoite was oval or irregular in shape. Ingestion of host cell cytoplasm occurred cystostomally. The asexual parasite possessed cristate mitochondria and was surrounded by a single-membraned pellicle. The gametocyte possessed cristate mitochondria and was surrounded by two unit membranes. The cytoplasm of mature macrogametocytes contained many ribosomes, mitochondria and osmiophilic bodies and a small nucleus while microgametocytes contained fewer ribosomes, osmiophilic bodies and mitochondria and a large nucleus. Three characteristic morphological alterations were observed within the host cells, that is, small vesicles, cytoplasmic cleft and caveola-vesicle complex. The clefts within the cytoplasm of the host erythrocytes were present in all human malarial parasites. The small vesicles distributed all over the cytoplasm were surrounded by a unit membrane. The caveola-vesicle complex consisted of caveolae was surrounded by small vesicles and probably corresponds to a Schüffner's dot. (Figs. 1-13).

Animals↗
PubMed1992

Subchronic toxicity studies of fenbendazole in rats.

The effects of prolonged exposure of rats to fenbendazole were investigated. Fenbendazole was given daily by gavage for 14 consecutive days. These dosages (3000, 500 or 50 mg/kg/d) produced reductions in body weight gains. Renal tubular hyperemia or hemorrhage and glomerular capsule dilation, increased serum creatinine and hepatocellular granular degeneration occurred at dosages of 500 and 3000 mg/kg/d. Renal tubular epithelial cell granular degeneration and tubular dilation, increased serum glutamic pyruvic transaminase, cardiac hemorrhage and granular degeneration also occurred at 3000 mg/kg/d.

Animals↗
PubMed1992

Effects of thymosin and insulin on suppressor T cell in type 1 diabetes.

In most studies the activity of suppressor T cells and the percentage of suppressor/cytotoxic T-lymphocyte subsets in type 1 diabetes have been found to be altered. To determine whether thymosin and insulin in vitro have a role in improving or normalizing these abnormalities, PBMC from 28 patients with type 1 diabetes of various durations were treated with thymosin or insulin and the activity and the percentage of suppressor T cells were detected by using the method of ConA-induced suppressor T cells and WuT8 (suppressor/cytotoxic) monoclonal antibody respectively. Both thymosin and insulin were found to have ability to improve and normalize the ConA-induced suppressor cell activity and the percentage of WuT8 cells in diabetic patients. Data have shown that the lower the activity and the percentage of suppressor T cells, the more intense the effects of both compounds. The strongest effects were found at the concentrations of 10 micrograms/ml thymosin and 10 ng/ml insulin. Thymosin was more effective than insulin. This experiment also suggested that the activated lymphocytes stimulated by mitogens (PHA or ConA) were required when insulin exerted a significant effect on suppressor T cells. We conclude that thymosin and insulin in vitro can exert immuno-regulatory or immunostimulating effects on suppressor T cells.

Adult↗
PubMed1992

[Lipid peroxides, antiperoxidase and the progressive course of experimental atherosclerosis].

Rabbits were fed on cholesterol-rich (CHO) diet first for 60 days, and serum cholesterol, serum lipid peroxides (LPO) and superoxide dismutase (SOD) activities were measured at various periods after the withdrawal of the CHO-rich diet. The correlation of the above figures and the initiation, progression and regression of atherosclerotic lesion were studied. Results showed that: (1) when rabbits were fed on a CHO-rich diet for 60 days, the serum CHO and LPO increased significantly. Anyhow, the SOD activity was only slightly elevated when tiny atherosclerotic lesions developed in the aortae. (2) right after withdrawal of the CHO diet, serum CHO decreased significantly, but atherosclerotic lesion became even more severe than before. (3) after withdrawal of the CHO diet for 120 days, serum CHO, LPO content and SOD activity all returned to normal range and the atheromatous lesion became less severe except calcification and fibrosis developed in certain areas.

Animals↗
PubMed1991

Insulin analogues with modifications in the beta-turn of the B-chain.

The beta-turn formed by the amino acid residues 20-23 of the B-chain of insulin has been implicated as an important structural feature of the molecule. In other biologically active peptides, stabilization of beta-turns has resulted in increases in activity. We have synthesized three insulin analogues containing modifications which would be expected to increase the stability of the beta-turn. In two analogues, we have substituted alpha-aminoisobutyric acid (Aib) for the Glu residue normally present in position B21 or for the Arg residue normally present in position B22; in a third compound, we have replaced the Glu residue with its D-isomer. Biological evaluation of these compounds showed that [B21 Aib]insulin displays a potency ca. one-fourth that of natural insulin, while [B22 Aib]insulin is less than 10% as potent. In contrast, [B21 D-Glu]insulin is equipotent with natural insulin. We conclude that the beta-turn region of the insulin molecule normally possesses considerable flexibility, which may be necessary for it to assume a conformation commensurate with high biological activity. If this is the case, [B21 D-Glu]insulin may exhibit a stabilized geometry similar to that of natural insulin when bound to the insulin receptor.

Adipose Tissue↗
PubMed1991

Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases.

Between 1 January 1980, and 30 September 1989, 93 cases of exposure to herbicides containing glyphosphate and surfactant ('Roundup') were treated at Changhua Christian Hospital. The average amount of the 41% solution of glyphosate herbicide ingested by non-survivors was 184 +/- 70 ml (range 85-200 ml), but much larger amounts (500 ml) were reported to have been ingested by some patients and only resulted in mild to moderate symptomatology. Accidental exposure was asymptomatic after dermal contact with spray (six cases), while mild oral discomfort occurred after accidental ingestion (13 cases). Intentional ingestion (80 cases) resulted in erosion of the gastrointestinal tract (66%), seen as sore throat (43%), dysphagia (31%), and gastrointestinal haemorrhage (8%). Other organs were affected less often (non-specific leucocytosis 65%, lung 23%, liver 19%, cardiovascular 18%, kidney 14%, and CNS 12%). There were seven deaths, all of which occurred within hours of ingestion, two before the patient arrived at the hospital. Deaths following ingestion of 'Roundup' alone were due to a syndrome that involved hypotension, unresponsive to intravenous fluids or vasopressor drugs, and sometimes pulmonary oedema, in the presence of normal central venous pressure.

Adolescent↗
PubMed1991

[A comparison of patient-controlled analgesia with traditional intramuscular administration for postoperative pain relief].

The use of a disposable non-electronic patient-controlled analgesia (PCA) device (Baxter) was evaluated in this study. Every patient under trial was instructed thoroughly how to use the PCA device before operation. The PCA device delivers a 25 mg IV injection of pethidine upon patient demand with a delay of 15 min between allowable administrations. The degree of patient satisfaction, the drug consumption, and the duration of using analgesia were compared with those in IM pethidine group. The results showed that, in the PCA group, the duration of using analgesic was longer; the drug consumption was greater (especially during the first 20 h after operation); and the degree of patient satisfaction was higher. The series comprised a total of 54 patients, 14 of whom complained of mild dizziness or nausea which did not require specific treatment. In sum, giving analgesic by the Baxter PCA device was a safe and effective alternative for IM analgesic in postoperative pain control.

Analgesia, Patient-Controlled↗
PubMed1991

[Clinical evaluation of anti-DNAse B test in rheumatic fever and rheumatic heart disease].

Anti-DNAse B test was performed with microtechnique in 160 subjects including patients with acute streptococcal pharyngitis, rheumatic fever and rheumatic heart disease as well as normal controls. It was shown that the antibody titer varied with age, stage of rheumatic fever and rheumatic heart disease as well as the frequency of benthazine penicillin injections. It was also shown in this study that the school children group had considerably higher geometric mean antibody titer than the adult group. The upper normal limit of anti-DNAse B titer was 240 units in the school children group and 160 units in the adult group. The anti-DNAse B test shows a higher positive detection rate for streptococcal infection than ASO, especially when these two tests are used in combination. In patients with manifestations of acute rheumatic fever without elevation of ASO titer, anti-DNAse B test will be of great diagnostic value.

Adolescent↗
PubMed1991

[Ulnar variance].

Explore the source record for details and available documents.

Anthropometry↗
PubMed1991

Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. I. Clinical and parasitologic observations.

We compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) for the control of microfilaremia in 60 patients with bancroftian filariasis who had developed recurrent microfilaremia after each of three or more prior treatments with DEC. The study was done as a randomized, double-blind trial. Complete, but in some cases, transient clearance of microfilaremia was observed in both treatment groups. At one year, recurrent microfilaremia was present in seven patients treated with ivermectin and in five treated with DEC. Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremic. Side effects with both treatments were common, but mild. Febrile reactions were more frequent in the ivermectin group; localized reactions consistent with a flare-up of acute filarial disease occurred mostly in the DEC group. We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.

Adolescent↗
PubMed1991

Efficacy of ivermectin for control of microfilaremia recurring after treatment with diethylcarbamazine. II. Immunologic changes following treatment.

We compared the effect of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) on several parameters of the host's antifilarial immune response in 60 patients with bancroftian filariasis enrolled in a double-blind drug trial. All participants had measurable serum levels of antifilarial antibodies and parasite antigens at the onset of the study. Drug-induced clearance of microfilaremia was associated with a temporary increase in HC 11 antigenemia and a decrease in serum levels of antibodies to soluble filarial antigens. Antigenemia progressively declined in patients who remained amicrofilaremic after treatment, but declined and then increased in persons with recurrent microfilaremia. Treatment triggered a sustained increase in serum levels of interleukin-1, tumor necrosis factor, and interleukin-6 in all patients studied. Although ivermectin and DEC are believed to exert their antiparasite activity via different mechanisms, the same pattern of serologic changes was observed in patients treated with either drug.

Adolescent↗
PubMed1991

Survival and infectivity of Brugia malayi microfilariae after cryopreservation.

Methods were studied for the cryopreservation of microfilariae of periodic Brugia malayi. RPMI-1640 tissue culture medium containing 6% dimethyl sulfoxide (DMSO) and 15% newborn calf serum was used as cryoprotectant. Samples were frozen slowly in the vapor phase of liquid nitrogen prior to emersion in liquid nitrogen (-196 degrees C). The freezing rate was -0.5 to -1.0 degrees C per minute, microfilariae remained viable for as long as, 212 and 375 days, survival rates were 94 to 98% and they were infective to Aedes togoi mosquitos. The infective larvae (L3) were obtained for 10-11 days after feeding at 28 degrees C room-temperature and the infection rate of L3 in test mosquitos was 22.4-30.6%. All DMSO should be removed from the freezing medium to restore microfilariae activity after freezing.

Aedes↗